| Crisis Pregnancy Center of TidewaterEIN 54-1267311 | Health | VA | $1,618,062Small | 67.86 |
| Crisis Pregnancy Centers of Greater PhoenixEIN 86-0536082 | Health | AZ | $1,682,802Small | 79.16 |
| CRISTA MinistriesEIN 91-6012289 | Religion | WA | $114,902,453Large | 92.22 |
| Crohn's & Colitis Foundation EIN 13-6193105 | Health | NY | $75,664,404Large | 88.16 |
| Crooked Tree Arts CenterEIN 23-7187264 | Arts, Culture, Humanities | MI | $2,194,400Small | 82.56 |
| Cross Roads HouseEIN 22-2549963 | Human Services | NH | $1,740,795Small | 90.76 |
| Crossnore SchoolEIN 56-0567980 | Human Services | NC | $15,549,420Large | 94.62 |
| CrossOver Healthcare MinistryEIN 54-1371067 | Health | VA | $5,840,704Mid-sized | 89.02 |
| Crossroads CenterEIN 47-0700215 | Human Services | NE | $1,174,028Small | 65.07 |
| Crossroads Nogales MissionEIN 86-0804463 | Human Services | AZ | $920,167Small | 46.66 |
| Crossroads of MichiganEIN 38-2539852 | Human Services | MI | $1,325,518Small | 89.70 |
| Crossroads Prison MinistriesEIN 38-2540316 | Religion | MI | $1,852,405Small | 91.11 |
| Crossroads Urban CenterEIN 87-0295751 | Human Services | UT | $1,720,655Small | 94.78 |
| Crosstown Learning CenterEIN 73-0782748 | Human Services | OK | $2,339,373Small | 92.22 |
| Crosswinds Youth ServicesEIN 23-7376943 | Human Services | FL | $3,016,776Small | 87.25 |
| Crow Canyon Archaeological CenterEIN 84-0631786 | Arts, Culture, Humanities | CO | $4,488,765Mid-sized | 86.52 |
| Crown Financial MinistriesEIN 58-1260812 | Religion | TN | $4,923,465Mid-sized | 75.33 |
| Crown Point Community FoundationEIN 31-0247014 | Community Development | IN | $1,689,704Small | 83.83 |
| Crystal Peaks Youth RanchEIN 91-1821187 | Human Services | OR | $1,460,968Small | 70.49 |
| CSB MinistriesEIN 36-2472249 | Religion | NY | $740,300Small | 80.96 |
| Cultural Landscape FoundationEIN 52-2092229 | Environment | DC | $1,301,543Small | 86.63 |
| Cultural SurvivalEIN 23-7182593 | Human and Civil Rights | MA | $2,010,575Small | 88.27 |
| Cumberland Presbyterian Children's HomeEIN 75-0878543 | Human Services | TX | $2,798,013Small | 82.10 |
| Curamericas GlobalEIN 56-1400098 | International | NC | $1,138,062Small | 81.58 |
| Cure Alzheimer's FundEIN 52-2396428 | Health | MA | $18,999,554Large | 98.23 |
| CURE Childhood CancerEIN 58-1244138 | Health | GA | $6,232,633Mid-sized | 90.58 |
| CURE InternationalEIN 58-2248383 | International | MI | $62,536,689Large | 94.69 |
| Cure SMAEIN 36-3320440 | Health | IL | $7,566,017Mid-sized | 84.58 |
| CurePSPEIN 52-1704978 | Health | NY | $2,357,223Small | 80.65 |
| CuriOdysseyEIN 94-1262434 | Arts, Culture, Humanities | CA | $4,418,168Mid-sized | 86.57 |
| Curious Theatre CompanyEIN 84-1364297 | Arts, Culture, Humanities | CO | $1,227,492Small | 79.93 |
| Cystic Fibrosis Research, Inc.EIN 51-0169988 | Health | CA | $1,053,679Small | 100.00 |
| Cystinosis Research FoundationEIN 32-0067668 | Health | CA | $3,037,548Small | 90.72 |
| D-Rev Design for the Other Ninety PercentEIN 26-0642778 | Health | CA | $1,828,897Small | 88.06 |
| D. James Kennedy MinistriesEIN 65-0496702 | Religion | FL | $4,790,042Mid-sized | 85.12 |
| D.A.R.E. AmericaEIN 95-4242541 | Health | CA | $12,067,579Mid-sized | 70.66 |
| D.C. Bar Pro Bono CenterEIN 52-1574217 | Human and Civil Rights | DC | $2,824,873Small | 93.74 |
| D.C. Central KitchenEIN 52-1584936 | Human Services | DC | $16,677,394Large | 92.92 |
| Dakin Humane SocietyEIN 20-5318898 | Animals | MA | $3,483,198Small | 87.67 |
| Dakota Indian FoundationEIN 23-7112391 | Human Services | SD | $591,852Small | 27.44 |
| Dalit Freedom NetworkEIN 41-2075995 | International | VA | $2,220,867Small | 80.83 |
| Dallas Area Habitat for HumanityEIN 75-2097161 | Community Development | TX | $20,413,100Large | 91.70 |
| Dallas ContemporaryEIN 75-1575687 | Arts, Culture, Humanities | TX | $1,826,588Small | 87.23 |
| Dallas Holocaust MuseumEIN 75-2113723 | Arts, Culture, Humanities | TX | $3,316,399Small | 84.85 |
| Dallas Life FoundationEIN 75-2336522 | Human Services | TX | $4,054,566Mid-sized | 94.85 |
| Dallas Museum of ArtEIN 75-0808774 | Arts, Culture, Humanities | TX | $28,537,301Large | 81.64 |
| Dallas Theater CenterEIN 75-0959992 | Arts, Culture, Humanities | TX | $10,134,614Mid-sized | 81.30 |
| Dallas Zoological SocietyEIN 75-0964982 | Animals | TX | $12,677,533Mid-sized | 88.08 |
| Damon Runyon Cancer Research FoundationEIN 13-1933825 | Health | NY | $19,596,662Large | 94.78 |
| Dan Marino FoundationEIN 65-0320556 | Health | FL | $3,486,858Small | 93.39 |
| Dana-Farber Cancer InstituteEIN 04-2263040 | Health | MA | $1,528,239,259Large | 92.74 |
| Dance ExchangeEIN 52-1076232 | Arts, Culture, Humanities | MD | $447,360Small | 79.19 |
| Dance Theatre of HarlemEIN 13-2642091 | Arts, Culture, Humanities | NY | $5,536,736Mid-sized | 83.11 |
| Dance/USAEIN 52-1253457 | Arts, Culture, Humanities | DC | $2,307,036Small | 87.61 |
| Dane County Humane SocietyEIN 39-0806335 | Animals | WI | $3,719,068Mid-sized | 87.15 |
| Danforth ArtEIN 04-2526917 | Arts, Culture, Humanities | MA | $1,216,820Small | 75.73 |
| Daniel Murphy Scholarship FundEIN 36-3675466 | Education | IL | $3,844,516Mid-sized | 90.96 |
| Daniel Pitino ShelterEIN 61-1245271 | Human Services | KY | $1,558,230Small | 74.44 |
| Danita's ChildrenEIN 59-3735653 | International | TN | $2,153,385Small | 90.35 |
| DAPCEPEIN 38-2451827 | Education | MI | $2,229,825Small | 83.85 |