| Detroit Rescue Mission MinistriesEIN 38-1459371 | Human Services | MI | $20,146,632Large | 91.70 |
| Detroit Symphony OrchestraEIN 38-1385132 | Arts, Culture, Humanities | MI | $36,345,989Large | 92.06 |
| Detroit Zoological SocietyEIN 38-6027356 | Animals | MI | $40,691,390Large | 92.44 |
| Development Associates InternationalEIN 23-2838716 | Religion | CO | $5,989,502Mid-sized | 91.91 |
| Developments in LiteracyEIN 33-0843213 | Education | CA | $2,641,317Small | 91.12 |
| Dégagé MinistriesEIN 38-1912094 | Human Services | MI | $1,780,580Small | 80.83 |
| Dia Art FoundationEIN 23-7397946 | Arts, Culture, Humanities | NY | $16,546,314Large | 89.01 |
| Diabetes Action Research and Education FoundationEIN 52-1714027 | Health | MD | $2,249,926Small | 89.44 |
| Diabetes Foundation of MississippiEIN 23-7262987 | Health | MS | $804,695Small | 87.92 |
| Diabetes Research Institute FoundationEIN 59-1361955 | Health | FL | $9,613,760Mid-sized | 83.69 |
| Diabetes Youth FamiliesEIN 94-6003673 | Health | CA | $2,422,432Small | 88.04 |
| Dian Fossey Gorilla Fund InternationalEIN 52-1118866 | Animals | GA | $3,297,143Small | 92.38 |
| DIFFAEIN 13-3224150 | Health | NY | $2,754,888Small | 79.35 |
| Dikembe Mutombo FoundationEIN 58-2359589 | International | GA | $3,333,046Small | 75.95 |
| Dining for WomenEIN 20-0031928 | International | SC | $1,423,715Small | 88.01 |
| Direct ReliefEIN 95-1831116 | International | CA | $1,008,907,873Large | 100.00 |
| Disabled Police and Sheriff's FoundationEIN 36-4494026 | Human Services | MO | $2,265,836Small | 21.56 |
| Disabled Veterans National FoundationEIN 26-1446183 | Human Services | MD | $29,301,117Large | 29.25 |
| DiscipleMakersEIN 25-1411175 | Religion | PA | $4,832,863Mid-sized | 94.16 |
| Discovery Center of SpringfieldEIN 43-1568214 | Arts, Culture, Humanities | MO | $1,154,192Small | 85.38 |
| DISCOVERY Children's MuseumEIN 94-2943891 | Arts, Culture, Humanities | NV | $5,726,927Mid-sized | 88.33 |
| Discovery Eye FoundationEIN 95-4228653 | Health | CA | $897,538Small | 69.62 |
| Discovery Green ConservancyEIN 20-1951465 | Environment | TX | $7,362,363Mid-sized | 94.07 |
| Discovery InstituteEIN 91-1521697 | Research and Public Policy | WA | $5,325,118Mid-sized | 82.97 |
| Discovery MuseumEIN 04-2741645 | Arts, Culture, Humanities | MA | $1,841,437Small | 87.63 |
| Discovery PlaceEIN 56-0529944 | Arts, Culture, Humanities | NC | $15,241,959Large | 91.91 |
| Discovery WorldEIN 39-1691578 | Arts, Culture, Humanities | WI | $9,457,339Mid-sized | 90.71 |
| Diskin Orphan Fund of IsraelEIN 13-5608399 | Human Services | NY | $1,817,844Small | 75.86 |
| District of Columbia College Access ProgramEIN 52-2132835 | Education | DC | $7,157,083Mid-sized | 86.80 |
| DKT InternationalEIN 58-1593137 | International | DC | $199,519,332Large | 88.81 |
| Do SomethingEIN 13-3720473 | Human Services | NY | $10,095,721Mid-sized | 93.37 |
| Doctors CareEIN 84-1150815 | Health | CO | $2,543,801Small | 95.05 |
| Doctors Without Borders, USAEIN 13-3433452 | International | NY | $420,595,919Large | 94.74 |
| Doernbecher Children's Hospital FoundationEIN 93-0579589 | Health | OR | $12,481,925Mid-sized | 83.50 |
| Dogs for Better LivesEIN 93-0681311 | Animals | OR | $3,363,233Small | 95.93 |
| Dogwood AllianceEIN 56-2139120 | Environment | NC | $1,552,587Small | 88.31 |
| Doheny Eye InstituteEIN 95-2916590 | Health | CA | $23,595,251Large | 82.85 |
| Dollar Energy FundEIN 25-1442933 | Human Services | PA | $15,557,633Large | 91.16 |
| Dollywood FoundationEIN 62-1348105 | Education | TN | $2,763,686Small | 84.26 |
| Domestic Abuse Intervention ServicesEIN 39-1268238 | Human Services | WI | $3,256,031Small | 93.70 |
| Domestic Abuse ProjectEIN 41-1356278 | Human Services | MN | $1,595,408Small | 76.76 |
| Domestic Abuse Project of Delaware CountyEIN 23-2053144 | Human Services | PA | $1,766,699Small | 90.06 |
| Domestic Violence Center of Chester CountyEIN 22-2606511 | Human Services | PA | $1,767,014Small | 88.49 |
| Domestic Violence Intervention Services, Inc. (DVIS)EIN 73-1028332 | Human Services | OK | $6,638,122Mid-sized | 93.99 |
| Domestic Violence ProjectEIN 34-1263226 | Human Services | OH | $1,759,397Small | 86.59 |
| Domestic Violence Solutions for Santa Barbara CountyEIN 95-3495141 | Human Services | CA | $1,830,345Small | 84.41 |
| Donald W. Reynolds Boys & Girls ClubEIN 71-0254287 | Human Services | AR | $2,246,524Small | 88.23 |
| DonorsChoose.orgEIN 13-4129457 | Education | NY | $102,666,357Large | 96.66 |
| Doorways for Women and FamiliesEIN 54-1087829 | Human Services | VA | $4,770,512Mid-sized | 93.46 |
| DOROTEIN 13-3264005 | Human Services | NY | $7,626,167Mid-sized | 92.96 |
| Doug Flutie Jr. Foundation For AutismEIN 04-3543134 | Health | MA | $1,281,666Small | 87.31 |
| DoveLewis Emergency Animal HospitalEIN 93-0621534 | Animals | OR | $12,932,704Mid-sized | 86.84 |
| Downline MinistriesEIN 20-1374884 | Religion | TN | $1,631,991Small | 80.75 |
| Downtown Cleveland AllianceEIN 34-1775903 | Community Development | OH | $7,152,083Mid-sized | 81.88 |
| Downtown Community Television CenterEIN 13-2742777 | Arts, Culture, Humanities | NY | $3,066,888Small | 91.45 |
| Downtown Rescue MissionEIN 63-0735295 | Human Services | AL | $8,473,047Mid-sized | 90.69 |
| Downtown Women's CenterEIN 31-1597223 | Human Services | CA | $10,092,147Mid-sized | 89.78 |
| Dr. Susan Love Research FoundationEIN 77-0009065 | Health | CA | $2,750,486Small | 93.08 |
| DREAMEIN 13-4025290 | Human Services | NY | $15,172,457Large | 91.42 |
| Dream FactoryEIN 61-1220742 | Health | KY | $2,252,925Small | 92.38 |