| Dream FoundationEIN 77-0405779 | Health | CA | $4,761,331Mid-sized | 94.27 |
| Dreamchaser PMU Rescue & RehabilitationEIN 20-5168546 | Animals | MO | $1,306,857Small | 68.73 |
| Dreams Come TrueEIN 59-2967803 | Health | FL | $2,459,405Small | 92.22 |
| DreamYard ProjectEIN 13-3759661 | Education | NY | $5,082,563Mid-sized | 86.67 |
| Dress for Success HoustonEIN 76-0579697 | Human Services | TX | $2,618,328Small | 94.63 |
| Dress for Success WorldwideEIN 13-4040377 | Human Services | NY | $22,405,064Large | 91.40 |
| Drisha Institute for Jewish EducationEIN 13-2968932 | Religion | NY | $2,333,063Small | 75.76 |
| Drug Policy AllianceEIN 52-1516692 | Research and Public Policy | NY | $14,612,498Large | 76.86 |
| Drugs for Neglected Diseases Initiative North AmericaEIN 20-8774179 | Health | NY | $4,091,229Mid-sized | 84.44 |
| Dubuque County Historical SocietyEIN 42-6072050 | Arts, Culture, Humanities | IA | $7,001,981Mid-sized | 90.87 |
| Dubuque Regional Humane SocietyEIN 42-6039535 | Animals | IA | $1,228,456Small | 83.90 |
| Dumb Friends LeagueEIN 84-0405254 | Animals | CO | $18,015,992Large | 90.47 |
| DuPage Children's MuseumEIN 36-3565001 | Arts, Culture, Humanities | IL | $3,932,978Mid-sized | 84.78 |
| DuPage PADSEIN 36-3675494 | Human Services | IL | $4,142,129Mid-sized | 90.86 |
| Durham Rescue MissionEIN 58-1482590 | Human Services | NC | $11,976,198Mid-sized | 100.00 |
| Dutchess County SPCAEIN 14-1340058 | Animals | NY | $2,016,618Small | 85.23 |
| Dysautonomia FoundationEIN 13-6145280 | Health | NY | $2,427,386Small | 85.38 |
| Dystonia Medical Research FoundationEIN 95-3378526 | Health | IL | $2,608,986Small | 95.85 |
| Dystrophic Epidermolysis Bullosa Research Association of America (debra of America)EIN 11-2519726 | Health | NY | $1,416,573Small | 93.82 |
| dZi FoundationEIN 84-1595852 | International | CO | $1,351,526Small | 94.74 |
| e3 Partners MinistriesEIN 16-1680978 | Religion | TX | $18,419,441Large | 76.73 |
| Eagle MountEIN 84-1383214 | Health | MT | $1,623,071Small | 91.51 |
| Eagle RanchEIN 58-1497408 | Human Services | GA | $4,667,626Mid-sized | 93.88 |
| Eagles Charitable FoundationEIN 23-2794290 | Human Services | PA | $1,448,292Small | 84.23 |
| EARN, Inc. EIN 91-2172676 | Community Development | CA | $3,710,835Mid-sized | 91.23 |
| Earth Conservation CorpsEIN 52-1683270 | Environment | DC | $350,700Small | 74.09 |
| Earth Day NetworkEIN 13-3798288 | Environment | DC | $2,970,282Small | 91.94 |
| Earth ForceEIN 52-1830873 | Environment | CO | $1,002,263Small | 84.00 |
| Earth Island InstituteEIN 94-2889684 | Environment | CA | $9,751,020Mid-sized | 88.24 |
| EarthEcho InternationalEIN 95-4789334 | Environment | DC | $698,764Small | 82.66 |
| EarthjusticeEIN 94-1730465 | Environment | CA | $51,564,754Large | 94.85 |
| EarthplaceEIN 06-0740523 | Environment | CT | $2,425,838Small | 85.32 |
| EarthRights InternationalEIN 04-3265555 | International | DC | $3,343,499Small | 99.01 |
| EarthShareEIN 52-1601960 | Environment | MD | $6,743,365Mid-sized | 76.31 |
| EarthShare CaliforniaEIN 94-2840364 | Environment | CA | $1,349,632Small | 73.23 |
| EarthShare GeorgiaEIN 58-2022001 | Environment | GA | $635,892Small | 80.68 |
| EarthShare TexasEIN 74-2627643 | Environment | TX | $407,224Small | 84.86 |
| Earthwatch InstituteEIN 23-7168440 | Research and Public Policy | MA | $7,458,378Mid-sized | 86.99 |
| EARTHWORKSEIN 52-1557765 | Environment | DC | $3,301,953Small | 94.74 |
| East Bay Alliance for A Sustainable EconomyEIN 94-3314108 | Human Services | CA | $1,290,909Small | 91.25 |
| East Bay Community FoundationEIN 94-6070996 | Community Development | CA | $29,631,756Large | 87.62 |
| East Bay SPCAEIN 94-1322202 | Animals | CA | $10,413,347Mid-sized | 89.81 |
| East Cooper Community OutreachEIN 57-0939280 | Human Services | SC | $1,871,995Small | 97.17 |
| East End HouseEIN 04-2104163 | Human Services | MA | $2,610,655Small | 80.06 |
| East Harlem Tutorial ProgramEIN 23-7439789 | Education | NY | $9,065,798Mid-sized | 92.30 |
| East Lake FoundationEIN 58-2204306 | Community Development | GA | $16,362,404Large | 89.24 |
| East Side HouseEIN 13-1623989 | Human Services | NY | $22,000,963Large | 98.23 |
| East Tennessee PBSEIN 62-1173293 | Arts, Culture, Humanities | TN | $3,188,133Small | 90.71 |
| East Texas Crisis CenterEIN 75-1641173 | Human Services | TX | $2,141,385Small | 86.52 |
| East Texas Food BankEIN 75-2222686 | Human Services | TX | $32,138,551Large | 95.28 |
| East-West Center FoundationEIN 99-0218752 | International | HI | $819,979Small | 83.27 |
| East-West Ministries InternationalEIN 75-2486132 | Religion | TX | $17,806,811Large | 93.10 |
| Easter Seals Capper FoundationEIN 48-0543745 | Human Services | KS | $13,693,269Large | 92.92 |
| Eastern Illinois FoodbankEIN 37-1130252 | Human Services | IL | $19,826,056Large | 95.05 |
| Eastern Market CorporationEIN 32-0030432 | Community Development | MI | $5,687,857Mid-sized | 89.99 |
| Eastern Music FestivalEIN 56-0771005 | Arts, Culture, Humanities | NC | $2,334,231Small | 81.51 |
| Eastside Baby CornerEIN 91-1617032 | Human Services | WA | $7,561,571Mid-sized | 88.14 |
| Eastside College Preparatory SchoolEIN 94-3187806 | Education | CA | $8,497,745Mid-sized | 93.29 |
| Eastside Community MinistryEIN 31-0952074 | Human Services | OH | $698,117Small | 67.57 |
| EastWest InstituteEIN 13-3091844 | International | NY | $8,643,444Mid-sized | 91.02 |