| Dare 2 Share MinistriesEIN 84-0504202 | Religion | CO | $3,524,068Mid-sized | 85.23 |
| Dare to Care Food BankEIN 23-7345952 | Human Services | KY | $43,226,997Large | 97.26 |
| Daughters of Charity Services of San AntonioEIN 74-6106876 | Human Services | TX | $6,688,924Mid-sized | 89.78 |
| Daughters of the American RevolutionEIN 53-0205923 | Arts, Culture, Humanities | DC | $16,267,791Large | 75.61 |
| DAV (Disabled American Veterans) Charitable Service TrustEIN 52-1521276 | Human Services | KY | $7,103,580Mid-sized | 92.01 |
| Dave Thomas Foundation for AdoptionEIN 31-1356151 | Human Services | OH | $24,102,108Large | 96.29 |
| David Lynch Foundation for Consciousness-Based EducationEIN 83-0436453 | Education | NY | $12,365,779Mid-sized | 92.14 |
| David's HouseEIN 22-2593431 | Health | NH | $935,493Small | 77.06 |
| Davis Phinney FoundationEIN 20-0813566 | Health | CO | $1,889,395Small | 89.37 |
| Days End Farm Horse RescueEIN 52-1759077 | Animals | MD | $1,570,461Small | 90.22 |
| Dayspring InternationalEIN 51-0237239 | Religion | VA | $7,364,681Mid-sized | 72.03 |
| DaySpring VillaEIN 73-1474319 | Human Services | OK | $1,234,000Small | 84.00 |
| DaystarEIN 62-1244203 | Human Services | TN | $2,070,139Small | 85.73 |
| Daystar Life CenterEIN 65-0523539 | Human Services | FL | $1,115,568Small | 91.36 |
| Dayton Art InstituteEIN 31-0537480 | Arts, Culture, Humanities | OH | $5,217,588Mid-sized | 84.58 |
| Dayton Contemporary Dance CompanyEIN 23-7220259 | Arts, Culture, Humanities | OH | $1,339,004Small | 72.01 |
| Dayton HistoryEIN 31-6037490 | Arts, Culture, Humanities | OH | $5,703,691Mid-sized | 92.22 |
| Dayton Masonic FoundationEIN 31-1385609 | Arts, Culture, Humanities | OH | $780,648Small | 80.86 |
| Dayton Performing Arts AllianceEIN 31-6000101 | Arts, Culture, Humanities | OH | $8,167,915Mid-sized | 83.97 |
| Dayton Society of Natural HistoryEIN 31-0585917 | Arts, Culture, Humanities | OH | $5,296,073Mid-sized | 79.89 |
| DEA Educational FoundationEIN 52-1922097 | Health | DC | $1,197,681Small | 81.54 |
| Deborah Hospital FoundationEIN 22-2049500 | Health | NJ | $11,597,550Mid-sized | 93.83 |
| Deborah's PlaceEIN 36-3382973 | Human Services | IL | $3,473,862Small | 94.48 |
| DeCordova Sculpture Park and MuseumEIN 04-2067315 | Arts, Culture, Humanities | MA | $4,862,222Mid-sized | 79.43 |
| Defenders of Animal RightsEIN 52-1061126 | Animals | MD | $1,124,255Small | 83.40 |
| Delancey Street FoundationEIN 23-7102690 | Human Services | CA | $102,283,206Large | 91.45 |
| Delaware Art MuseumEIN 51-0065746 | Arts, Culture, Humanities | DE | $5,189,312Mid-sized | 87.68 |
| Delaware Humane AssociationEIN 51-0082499 | Animals | DE | $1,765,553Small | 88.10 |
| Delaware Museum of Natural HistoryEIN 51-0083535 | Arts, Culture, Humanities | DE | $2,423,622Small | 89.09 |
| Delaware Nature SocietyEIN 51-6018321 | Environment | DE | $4,326,285Mid-sized | 91.54 |
| Delaware Riverkeeper NetworkEIN 74-3255972 | Environment | PA | $2,931,825Small | 88.44 |
| Delaware Valley Golden Retriever RescueEIN 23-2775413 | Animals | PA | $1,370,710Small | 85.34 |
| Delivering GoodEIN 13-3300271 | Human Services | NY | $217,120,707Large | 94.69 |
| Delta Waterfowl FoundationEIN 53-0259796 | Animals | ND | $9,628,880Mid-sized | 87.69 |
| Democracy North CarolinaEIN 56-2271150 | Human and Civil Rights | NC | $2,142,045Small | 92.78 |
| Democracy Now!EIN 01-0708733 | Arts, Culture, Humanities | NY | $7,100,320Mid-sized | 81.61 |
| DemosEIN 13-4105066 | Research and Public Policy | NY | $11,762,460Mid-sized | 87.62 |
| Denison Pequotsepos Nature CenterEIN 06-0884024 | Environment | CT | $1,362,888Small | 76.92 |
| Denver Art MuseumEIN 84-6038240 | Arts, Culture, Humanities | CO | $41,996,799Large | 91.19 |
| Denver Botanic GardensEIN 84-0440359 | Environment | CO | $21,365,255Large | 90.84 |
| Denver Center for the Performing ArtsEIN 84-0407760 | Arts, Culture, Humanities | CO | $52,094,113Large | 83.04 |
| Denver Film SocietyEIN 84-0771070 | Arts, Culture, Humanities | CO | $4,826,421Mid-sized | 88.24 |
| Denver Inner City ParishEIN 84-0525768 | Human Services | CO | $2,181,377Small | 88.50 |
| Denver Kids, Inc.EIN 84-1244211 | Education | CO | $2,435,764Small | 82.44 |
| Denver Public Library Friends FoundationEIN 84-6036979 | Arts, Culture, Humanities | CO | $2,403,593Small | 90.64 |
| Denver Rescue MissionEIN 84-6038762 | Human Services | CO | $32,935,233Large | 89.43 |
| Denver Scholarship FoundationEIN 20-5143175 | Education | CO | $9,338,023Mid-sized | 87.89 |
| Denver Street SchoolEIN 84-1216351 | Education | CO | $1,185,964Small | 88.99 |
| Denver Zoological FoundationEIN 84-0502539 | Animals | CO | $42,618,070Large | 88.57 |
| Depression and Bipolar Support Alliance, National OfficeEIN 36-3379124 | Health | IL | $2,387,816Small | 84.40 |
| Dermatology FoundationEIN 04-6115524 | Health | IL | $5,453,832Mid-sized | 81.36 |
| Des Moines Art CenterEIN 42-0680419 | Arts, Culture, Humanities | IA | $8,717,426Mid-sized | 91.88 |
| Des Moines Community PlayhouseEIN 42-0710259 | Arts, Culture, Humanities | IA | $2,660,897Small | 88.27 |
| Descanso Gardens Guild, Inc.EIN 95-2511202 | Environment | CA | $8,740,038Mid-sized | 89.78 |
| Desert AIDS ProjectEIN 33-0068583 | Health | CA | $32,043,691Large | 95.02 |
| Desert Botanical GardenEIN 86-0136925 | Environment | AZ | $15,606,893Large | 83.88 |
| Desire Street MinistriesEIN 72-1218825 | Religion | GA | $2,453,814Small | 94.46 |
| Detroit Historical SocietyEIN 38-1381144 | Arts, Culture, Humanities | MI | $5,818,479Mid-sized | 90.52 |
| Detroit Lakes Community & Cultural CenterEIN 41-1970351 | Human Services | MN | $2,571,753Small | 73.98 |
| Detroit Police Athletic LeagueEIN 38-3314318 | Human Services | MI | $2,897,572Small | 81.98 |