| Interfaith Community Services of Pima CountyEIN 86-0520997 | Human Services | AZ | $5,912,357Mid-sized | 98.23 |
| Interfaith Community Services, CaliforniaEIN 95-3837714 | Human Services | CA | $12,774,551Mid-sized | 92.90 |
| Interfaith Family ServicesEIN 75-2028254 | Human Services | TX | $1,743,817Small | 90.51 |
| Interfaith Food PantryEIN 22-3618468 | Human Services | NJ | $4,115,577Mid-sized | 94.06 |
| Interfaith Ministries for Greater HoustonEIN 74-1488102 | Human Services | TX | $17,732,074Large | 96.13 |
| Interfaith Outreach & Community PartnersEIN 36-3482724 | Human Services | MN | $8,323,002Mid-sized | 96.92 |
| International AIDS Vaccine InitiativeEIN 13-3870223 | Health | NY | $85,397,465Large | 92.92 |
| International Center for JournalistsEIN 11-2724905 | International | DC | $12,304,327Mid-sized | 97.75 |
| International Children's CareEIN 93-0717332 | International | WA | $4,074,715Mid-sized | 90.60 |
| International Children's FundEIN 39-1303430 | International | WI | $51,113,670Large | 92.27 |
| International Christian ConcernEIN 52-1942990 | Religion | DC | $2,483,260Small | 93.31 |
| International Community FoundationEIN 33-0457858 | International | CA | $11,867,287Mid-sized | 97.17 |
| International Cooperating MinistriesEIN 54-6338714 | Religion | VA | $23,865,869Large | 96.46 |
| International Crane FoundationEIN 39-1187711 | Animals | WI | $6,849,740Mid-sized | 91.97 |
| International Disaster Emergency ServiceEIN 23-7348277 | International | IN | $5,624,560Mid-sized | 97.76 |
| International Folk Art AllianceEIN 35-2285824 | Arts, Culture, Humanities | NM | $3,349,957Small | 92.45 |
| International Institute of Rural Reconstruction (IIRR)EIN 13-6175722 | International | NY | $4,270,136Mid-sized | 90.00 |
| International Leadership InstituteEIN 31-1803122 | Religion | GA | $2,737,716Small | 91.15 |
| International MessengersEIN 41-1652782 | Religion | IA | $4,549,161Mid-sized | 93.28 |
| International Myeloma FoundationEIN 95-4296919 | Health | CA | $16,025,421Large | 92.92 |
| International Peace InstituteEIN 03-0213226 | International | NY | $9,589,196Mid-sized | 95.34 |
| International Planned Parenthood Federation/Western Hemisphere RegionEIN 13-1845455 | Health | NY | $29,392,929Large | 93.32 |
| International Primate Protection LeagueEIN 51-0194013 | Animals | SC | $1,096,700Small | 97.24 |
| International Relief TeamsEIN 33-0412751 | International | CA | $38,184,357Large | 95.58 |
| International Rescue CommitteeEIN 13-5660870 | International | NY | $694,099,188Large | 91.16 |
| International Rett Syndrome FoundationEIN 31-1682518 | Health | OH | $5,001,314Mid-sized | 91.42 |
| International Rhino FoundationEIN 75-2395006 | Animals | TX | $2,814,196Small | 93.96 |
| International SamaritanEIN 34-1811907 | International | MI | $2,056,011Small | 90.09 |
| International Waldenstrom's Macroglobulinemia FoundationEIN 54-1784426 | Health | FL | $2,762,604Small | 95.29 |
| International Wolf CenterEIN 41-1543539 | Animals | MN | $1,624,232Small | 95.22 |
| International Women's Health CoalitionEIN 23-7378153 | International | NY | $6,565,003Mid-sized | 94.76 |
| International Youth FoundationEIN 38-2935397 | International | MD | $22,195,791Large | 90.04 |
| Intersection for the ArtsEIN 94-1593216 | Arts, Culture, Humanities | CA | $3,286,407Small | 95.00 |
| InterVarsity Christian Fellowship/USAEIN 36-2171714 | Religion | WI | $101,308,282Large | 90.91 |
| Investigative Reporters & EditorsEIN 51-0166741 | Education | MO | $2,500,441Small | 91.67 |
| Iona Senior ServicesEIN 52-1039553 | Human Services | DC | $4,589,586Mid-sized | 94.78 |
| IpasEIN 56-1071085 | Human and Civil Rights | NC | $63,318,776Large | 91.61 |
| Iranian American Jewish Federation of New YorkEIN 01-0651843 | Community Development | NY | $4,104,978Mid-sized | 98.23 |
| Irish International Immigrant CenterEIN 04-3063382 | Human Services | MA | $1,920,895Small | 95.61 |
| Irvine Nature CenterEIN 52-1231286 | Environment | MD | $1,926,838Small | 90.75 |
| Islamic Relief USAEIN 95-4453134 | International | VA | $150,398,532Large | 91.16 |
| Island HarvestEIN 11-3136350 | Human Services | NY | $20,780,134Large | 91.09 |
| IslandWoodEIN 31-1654076 | Education | WA | $9,854,727Mid-sized | 90.56 |
| Israel Cancer Association USAEIN 13-6218184 | Health | FL | $826,326Small | 96.66 |
| Israel Guide Dog Center for the BlindEIN 23-2519029 | Animals | PA | $3,959,395Mid-sized | 100.00 |
| It's The Journey, Inc.EIN 47-0897591 | Health | GA | $1,675,912Small | 92.27 |
| Jacksonville Public Education FundEIN 59-2756660 | Education | FL | $2,224,299Small | 91.64 |
| Jacob Burns Film CenterEIN 13-4038441 | Arts, Culture, Humanities | NY | $8,301,557Mid-sized | 94.09 |
| Jacob's Pillow DanceEIN 04-6002993 | Arts, Culture, Humanities | MA | $7,337,132Mid-sized | 91.76 |
| Jacobs & Cushman San Diego Food BankEIN 20-4374795 | Human Services | CA | $39,659,820Large | 95.26 |
| JAFCOEIN 20-0898587 | Human Services | FL | $7,240,169Mid-sized | 91.47 |
| Jazz at Lincoln CenterEIN 13-3888641 | Arts, Culture, Humanities | NY | $42,594,869Large | 91.51 |
| Jazz St. LouisEIN 43-1761629 | Arts, Culture, Humanities | MO | $3,208,441Small | 90.81 |
| JBI InternationalEIN 13-1683279 | Human Services | NY | $3,545,267Mid-sized | 90.24 |
| Jeffrey Modell FoundationEIN 13-3380237 | Health | NY | $6,352,516Mid-sized | 93.94 |
| Jersey Battered Women's ServiceEIN 22-2170048 | Human Services | NJ | $4,147,514Mid-sized | 98.98 |
| Jewish Alliance of Greater Rhode IslandEIN 05-0259003 | Community Development | RI | $3,504,762Mid-sized | 95.25 |
| Jewish Big Brothers Big Sisters of Los AngelesEIN 95-1691009 | Human Services | CA | $4,775,195Mid-sized | 95.01 |
| Jewish Community Center of Greater RochesterEIN 16-0743060 | Human Services | NY | $13,341,629Mid-sized | 91.62 |
| Jewish Community Center of San FranciscoEIN 94-3227260 | Human Services | CA | $37,902,425Large | 90.05 |