| Midori & FriendsEIN 13-3682472 | Education | NY | $1,764,343Small | 91.24 |
| MidTown ClevelandEIN 34-1381334 | Community Development | OH | $800,640Small | 90.17 |
| Midwest Athletes Against Childhood CancerEIN 39-1270290 | Health | WI | $4,138,694Mid-sized | 95.07 |
| Midwest Food Bank, NFPEIN 41-2120170 | Human Services | IL | $159,759,526Large | 94.69 |
| Migration Policy InstituteEIN 52-2279789 | International | DC | $6,001,797Mid-sized | 91.90 |
| Mikva ChallengeEIN 52-2033353 | Education | IL | $3,434,395Small | 95.01 |
| Milkweed EditionsEIN 41-1365177 | Arts, Culture, Humanities | MN | $2,115,151Small | 92.88 |
| Mill River Park CollaborativeEIN 06-1507648 | Environment | CT | $1,758,191Small | 91.45 |
| Millionair Club CharityEIN 91-0607513 | Human Services | WA | $6,538,256Mid-sized | 92.24 |
| Milwaukee Art MuseumEIN 39-0806316 | Arts, Culture, Humanities | WI | $19,236,271Large | 91.01 |
| Milwaukee Jewish FederationEIN 39-0806312 | Community Development | WI | $25,533,075Large | 94.75 |
| Milwaukee Repertory TheaterEIN 39-0946025 | Arts, Culture, Humanities | WI | $11,651,807Mid-sized | 94.90 |
| Ministry of CaringEIN 51-0209843 | Human Services | DE | $10,407,336Mid-sized | 94.95 |
| Ministry With CommunityEIN 38-2596981 | Human Services | MI | $1,675,939Small | 92.12 |
| Minnesota Adult & Teen ChallengeEIN 41-1517351 | Health | MN | $33,498,517Large | 99.77 |
| Minnesota Center for Environmental AdvocacyEIN 23-7412105 | Environment | MN | $1,692,871Small | 93.82 |
| Minnesota Environmental PartnershipEIN 41-1986433 | Environment | MN | $651,587Small | 90.47 |
| Minnesota OrchestraEIN 41-0693875 | Arts, Culture, Humanities | MN | $33,889,255Large | 92.09 |
| Minnesota Public Radio | American Public MediaEIN 41-0953924 | Arts, Culture, Humanities | MN | $98,123,227Large | 92.68 |
| Minority Corporate Counsel AssociationEIN 13-3920905 | Human and Civil Rights | DC | $2,948,017Small | 91.16 |
| Mint Theater CompanyEIN 13-3687725 | Arts, Culture, Humanities | NY | $1,894,443Small | 90.96 |
| Miracle FoundationEIN 74-2989580 | International | TX | $2,588,178Small | 92.54 |
| Miriam's KitchenEIN 52-1331552 | Human Services | DC | $4,421,295Mid-sized | 92.92 |
| MisericordiaEIN 36-2170153 | Human Services | IL | $68,981,056Large | 94.47 |
| Mises InstituteEIN 52-1263436 | Research and Public Policy | AL | $4,165,289Mid-sized | 94.70 |
| Mission Arlington/Mission MetroplexEIN 75-2354962 | Religion | TX | $3,860,708Mid-sized | 96.15 |
| Mission of MercyEIN 86-0704883 | Health | PA | $7,151,522Mid-sized | 93.89 |
| Mission Waco Mission WorldEIN 74-2605621 | Religion | TX | $2,644,683Small | 98.01 |
| Mission: HopeEIN 64-0866959 | International | GA | $2,410,206Small | 93.89 |
| Mississippi Children's MuseumEIN 64-0850010 | Arts, Culture, Humanities | MS | $3,541,158Mid-sized | 97.17 |
| Missoula Food BankEIN 81-0414143 | Human Services | MT | $4,608,782Mid-sized | 93.32 |
| Missouri History MuseumEIN 43-0654866 | Arts, Culture, Humanities | MO | $21,586,472Large | 97.14 |
| Missouri Slope Areawide United WayEIN 45-0387741 | Community Development | ND | $2,223,133Small | 91.83 |
| Mitchell InstituteEIN 01-0523390 | Education | ME | $2,338,190Small | 91.15 |
| Mobile Loaves & FishesEIN 74-2956081 | Human Services | TX | $6,045,166Mid-sized | 98.23 |
| Mobile Meal Service of Spartanburg CountyEIN 57-0653452 | Human Services | SC | $2,170,786Small | 92.07 |
| Moms in Prayer InternationalEIN 33-0417450 | Religion | CA | $1,374,397Small | 91.35 |
| Monarch School ProjectEIN 33-0871354 | Education | CA | $2,750,525Small | 97.56 |
| Montalvo Arts CenterEIN 94-1249283 | Arts, Culture, Humanities | CA | $5,707,512Mid-sized | 92.12 |
| Montana Food Bank NetworkEIN 81-0421243 | Human Services | MT | $18,322,391Large | 95.47 |
| Montana Wilderness AssociationEIN 51-0198932 | Environment | MT | $2,264,339Small | 96.25 |
| Monterey Bay AquariumEIN 94-2487469 | Animals | CA | $89,299,945Large | 97.27 |
| Montgomery Area Food BankEIN 63-0931846 | Human Services | AL | $37,449,188Large | 93.59 |
| Montgomery County SPCAEIN 23-1425036 | Animals | PA | $2,321,057Small | 92.13 |
| More Than WordsEIN 04-2784985 | Human Services | MA | $4,031,601Mid-sized | 90.58 |
| Morris Habitat for HumanityEIN 22-2675802 | Community Development | NJ | $6,111,048Mid-sized | 92.92 |
| Morven Museum & GardenEIN 22-2817982 | Arts, Culture, Humanities | NJ | $1,360,354Small | 92.04 |
| Mote Marine LaboratoryEIN 59-0756643 | Research and Public Policy | FL | $22,091,552Large | 92.18 |
| Mount Desert Island Biological LaboratoryEIN 01-0202467 | Research and Public Policy | ME | $11,741,518Mid-sized | 92.61 |
| Mountain Association for Community Economic DevelopmentEIN 31-0900246 | Community Development | KY | $5,071,264Mid-sized | 96.63 |
| Mountain HumaneEIN 82-0351171 | Animals | ID | $2,454,867Small | 92.81 |
| Mountains to Sound Greenway TrustEIN 91-1531234 | Environment | WA | $3,230,631Small | 96.46 |
| MouseEIN 13-3973196 | Education | NY | $2,010,423Small | 94.27 |
| Moving Picture InstituteEIN 20-3237801 | Arts, Culture, Humanities | NY | $3,489,969Small | 97.87 |
| Mozilla FoundationEIN 20-0097189 | Education | CA | $24,206,401Large | 96.07 |
| MSPCA-AngellEIN 04-2103597 | Animals | MA | $64,880,058Large | 92.20 |
| Museum of Discovery and ScienceEIN 59-1709542 | Arts, Culture, Humanities | FL | $9,225,857Mid-sized | 96.64 |
| Museum of FlightEIN 91-0785826 | Arts, Culture, Humanities | WA | $23,340,173Large | 92.15 |
| Museum of New Mexico FoundationEIN 85-0202503 | Arts, Culture, Humanities | NM | $5,184,980Mid-sized | 93.44 |
| Museum of Photographic ArtsEIN 95-2889390 | Arts, Culture, Humanities | CA | $2,843,158Small | 91.45 |