| Chesapeake ConservancyEIN 26-2271377 | Environment | MD | $4,045,632Mid-sized | 97.13 |
| Chicago Academy of Sciences / Peggy Notebaert Nature MuseumEIN 36-0895575 | Arts, Culture, Humanities | IL | $6,434,381Mid-sized | 87.59 |
| Chicago Bar FoundationEIN 36-6109584 | Human and Civil Rights | IL | $4,461,315Mid-sized | 88.90 |
| Chicago Children's ChoirEIN 51-0140419 | Education | IL | $4,025,337Mid-sized | 82.63 |
| Chicago Children's MuseumEIN 36-3162484 | Arts, Culture, Humanities | IL | $7,043,221Mid-sized | 81.00 |
| Chicago Hope AcademyEIN 36-4244054 | Education | IL | $4,257,955Mid-sized | 84.66 |
| Chicago Humanities FestivalEIN 36-7148236 | Arts, Culture, Humanities | IL | $3,736,155Mid-sized | 83.39 |
| Chicago Public Library FoundationEIN 36-3480353 | Arts, Culture, Humanities | IL | $7,357,415Mid-sized | 92.92 |
| Chicago Scholars FoundationEIN 36-4117530 | Education | IL | $4,037,945Mid-sized | 90.73 |
| Chicago Youth CentersEIN 36-2344429 | Human Services | IL | $8,586,171Mid-sized | 87.30 |
| Child AdvocatesEIN 76-0111345 | Human Services | TX | $5,333,168Mid-sized | 91.93 |
| Child FoundationEIN 93-1148608 | International | OR | $3,995,592Mid-sized | 92.92 |
| Child's PlayEIN 20-3584556 | Health | WA | $3,996,291Mid-sized | 71.00 |
| Childcare WorldwideEIN 95-3619910 | International | WA | $4,182,917Mid-sized | 85.01 |
| ChildhavenEIN 91-0402430 | Human Services | WA | $10,610,919Mid-sized | 92.67 |
| Children IncorporatedEIN 54-0761510 | International | VA | $3,816,918Mid-sized | 92.51 |
| Children NowEIN 94-3059243 | Education | CA | $7,605,949Mid-sized | 92.02 |
| Children of Armenia FundEIN 11-3579187 | International | NY | $4,802,238Mid-sized | 92.35 |
| Children of Fallen Patriots FoundationEIN 47-0902295 | Education | VA | $5,861,743Mid-sized | 95.38 |
| Children of the NationsEIN 91-1702551 | International | WA | $8,130,373Mid-sized | 91.16 |
| Children's Advocacy Center of Collin CountyEIN 75-2389095 | Human Services | TX | $3,869,558Mid-sized | 91.85 |
| Children's Cancer AssociationEIN 93-1181662 | Health | OR | $4,563,802Mid-sized | 82.81 |
| Children's Cancer Research FundEIN 41-1893645 | Health | MN | $12,733,452Mid-sized | 81.03 |
| Children's CupEIN 42-1385361 | International | TX | $5,837,843Mid-sized | 81.13 |
| Children's Discovery Museum of San JoseEIN 94-2870828 | Arts, Culture, Humanities | CA | $7,948,465Mid-sized | 98.67 |
| Children's FundEIN 33-0193286 | Human Services | CA | $4,099,530Mid-sized | 87.70 |
| Children's HarborEIN 57-0892070 | Health | AL | $4,506,020Mid-sized | 82.52 |
| Children's HopeChestEIN 33-0430285 | International | CO | $7,410,372Mid-sized | 88.85 |
| Children's Hospital FoundationEIN 73-1200262 | Health | OK | $5,317,283Mid-sized | 94.45 |
| Children's Museum of Denver at Marsico CampusEIN 84-0658142 | Arts, Culture, Humanities | CO | $6,549,972Mid-sized | 89.42 |
| Children's Museum of HoustonEIN 74-2178563 | Arts, Culture, Humanities | TX | $12,927,106Mid-sized | 94.76 |
| Children's Museum of ManhattanEIN 13-2761376 | Arts, Culture, Humanities | NY | $6,228,084Mid-sized | 85.38 |
| Children's Museum of PittsburghEIN 25-1379704 | Arts, Culture, Humanities | PA | $9,511,848Mid-sized | 92.68 |
| Children's Museum of RichmondEIN 51-0220694 | Arts, Culture, Humanities | VA | $3,922,438Mid-sized | 88.62 |
| Children's Organ Transplant AssociationEIN 35-1674365 | Health | IN | $6,400,704Mid-sized | 97.27 |
| Children's RightsEIN 13-3801864 | Human Services | NY | $5,161,356Mid-sized | 81.71 |
| Children's Scholarship Fund PhiladelphiaEIN 23-3078729 | Education | PA | $11,496,186Mid-sized | 98.87 |
| Children's Theatre CompanyEIN 41-1254553 | Arts, Culture, Humanities | MN | $12,400,825Mid-sized | 84.30 |
| Children's Tumor FoundationEIN 13-2298956 | Health | NY | $12,638,073Mid-sized | 85.15 |
| ChildSafeEIN 74-2633697 | Human Services | TX | $3,680,115Mid-sized | 91.92 |
| China Institute in AmericaEIN 13-1623937 | International | NY | $6,411,288Mid-sized | 83.96 |
| Chofetz Chaim Heritage FoundationEIN 11-2642599 | Religion | NY | $4,420,325Mid-sized | 76.99 |
| CHOICE HumanitarianEIN 74-2494806 | International | UT | $4,351,406Mid-sized | 90.58 |
| Christ HouseEIN 52-1362103 | Human Services | DC | $4,017,498Mid-sized | 89.82 |
| Christel House InternationalEIN 35-2051932 | Human Services | IN | $10,602,595Mid-sized | 91.83 |
| Christian Center Of Park CityEIN 87-0643778 | Human Services | UT | $4,693,519Mid-sized | 91.45 |
| Christian Community Action, TexasEIN 23-7319371 | Human Services | TX | $4,628,975Mid-sized | 85.31 |
| Christian Family CareEIN 86-0430037 | Human Services | AZ | $9,176,777Mid-sized | 94.56 |
| Christian Medical & Dental AssociationsEIN 36-2284267 | Religion | TN | $12,214,968Mid-sized | 89.73 |
| Christian Motorcyclists AssociationEIN 75-1645187 | Religion | AR | $6,632,081Mid-sized | 92.55 |
| Christian Relief FundEIN 51-0183054 | International | TX | $7,338,228Mid-sized | 95.32 |
| Christian Research InstituteEIN 22-6063412 | Religion | NC | $4,231,851Mid-sized | 71.88 |
| Christian UnionEIN 22-3834440 | Religion | NJ | $10,913,876Mid-sized | 89.74 |
| Chrysler Museum of ArtEIN 51-0243196 | Arts, Culture, Humanities | VA | $10,789,489Mid-sized | 90.90 |
| Churches of Christ Disaster Relief EffortEIN 62-1560072 | Human Services | TN | $7,348,103Mid-sized | 85.15 |
| Cibolo Nature Center & FarmEIN 74-2564700 | Environment | TX | $3,672,517Mid-sized | 85.33 |
| Cincinnati BalletEIN 31-6050354 | Arts, Culture, Humanities | OH | $9,444,521Mid-sized | 87.20 |
| Cincinnati Nature CenterEIN 31-6057978 | Environment | OH | $4,653,544Mid-sized | 77.13 |
| Cincinnati OperaEIN 31-0549044 | Arts, Culture, Humanities | OH | $7,768,378Mid-sized | 90.18 |
| Cincinnati Public RadioEIN 31-1410636 | Arts, Culture, Humanities | OH | $5,945,935Mid-sized | 86.02 |