| Catholic Social Services of Southern NebraskaEIN 47-0751554 | Human Services | NE | $6,160,111Mid-sized | 86.04 |
| CatholicTVEIN 04-2395520 | Religion | MA | $9,283,767Mid-sized | 80.75 |
| Caucus Educational CorporationEIN 22-3240680 | Arts, Culture, Humanities | NJ | $3,841,946Mid-sized | 74.88 |
| CBMCEIN 36-2004402 | Religion | TN | $9,309,673Mid-sized | 83.97 |
| CEAPEIN 41-0990340 | Human Services | MN | $4,193,723Mid-sized | 85.73 |
| CEDARSEIN 47-6024881 | Human Services | NE | $12,918,567Mid-sized | 95.72 |
| Celebrity Series of BostonEIN 22-2958508 | Arts, Culture, Humanities | MA | $7,898,914Mid-sized | 91.75 |
| Center for a New American SecurityEIN 20-8084828 | Research and Public Policy | DC | $9,751,151Mid-sized | 96.54 |
| Center for Action and ContemplationEIN 85-0354965 | Religion | NM | $5,261,149Mid-sized | 91.09 |
| Center for Child ProtectionEIN 74-2562585 | Human Services | TX | $5,770,355Mid-sized | 91.45 |
| Center for Climate and Energy SolutionsEIN 54-1892252 | Research and Public Policy | VA | $4,316,838Mid-sized | 84.09 |
| Center for Coastal StudiesEIN 04-2609788 | Environment | MA | $3,586,500Mid-sized | 94.03 |
| Center for Collaborative EducationEIN 04-3241676 | Education | MA | $4,694,075Mid-sized | 84.78 |
| Center for Constitutional RightsEIN 22-6082880 | Human and Civil Rights | NY | $10,523,997Mid-sized | 95.14 |
| Center For Consumer FreedomEIN 26-0006579 | Human and Civil Rights | DC | $3,930,347Mid-sized | 86.10 |
| Center for Food SafetyEIN 52-2165893 | Research and Public Policy | DC | $4,380,584Mid-sized | 85.99 |
| Center for Hearing and CommunicationEIN 13-1624127 | Human Services | NY | $5,685,758Mid-sized | 86.20 |
| Center for Initiatives in Jewish EducationEIN 77-0698155 | Education | NY | $4,342,419Mid-sized | 74.16 |
| Center for InquiryEIN 22-2306795 | Human and Civil Rights | DC | $4,833,092Mid-sized | 84.95 |
| Center for International PolicyEIN 52-1446207 | International | DC | $5,101,628Mid-sized | 88.46 |
| Center for Investigative ReportingEIN 94-2434026 | Arts, Culture, Humanities | CA | $13,182,677Mid-sized | 90.80 |
| Center for Jewish HistoryEIN 13-3863344 | Arts, Culture, Humanities | NY | $8,554,129Mid-sized | 86.15 |
| Center for Neighborhood TechnologyEIN 36-2967283 | Environment | IL | $4,290,326Mid-sized | 71.62 |
| Center for People in NeedEIN 06-1669552 | Human Services | NE | $8,432,172Mid-sized | 90.64 |
| Center for Public IntegrityEIN 54-1512177 | Research and Public Policy | DC | $5,208,118Mid-sized | 89.11 |
| Center for Puppetry ArtsEIN 58-1275610 | Arts, Culture, Humanities | GA | $4,233,410Mid-sized | 90.42 |
| Center for Safety and ChangeEIN 13-2989233 | Human Services | NY | $3,513,740Mid-sized | 90.09 |
| Center for Science in the Public InterestEIN 23-7122879 | Research and Public Policy | DC | $12,565,933Mid-sized | 85.45 |
| Center for Security PolicyEIN 52-1601976 | International | DC | $4,972,423Mid-sized | 91.36 |
| Center for Strategic and Budgetary AssessmentsEIN 52-1930922 | Research and Public Policy | DC | $8,653,272Mid-sized | 84.06 |
| Center for Talent InnovationEIN 13-3730312 | Research and Public Policy | NY | $4,340,285Mid-sized | 88.16 |
| Center for the National InterestEIN 26-2117013 | Research and Public Policy | DC | $4,008,865Mid-sized | 89.04 |
| Center for the Study of Social PolicyEIN 52-1254948 | Human Services | DC | $13,048,910Mid-sized | 89.42 |
| Center on HalstedEIN 51-0178807 | Human and Civil Rights | IL | $6,293,773Mid-sized | 97.46 |
| Center StageEIN 52-0780194 | Arts, Culture, Humanities | MD | $9,050,818Mid-sized | 86.65 |
| Central Asia InstituteEIN 51-0376237 | International | MT | $5,291,098Mid-sized | 84.66 |
| Central Florida Zoo & Botanical GardensEIN 59-1357197 | Animals | FL | $5,702,682Mid-sized | 92.50 |
| Central Institute for the DeafEIN 43-0662456 | Education | MO | $7,510,069Mid-sized | 93.44 |
| Central Oklahoma Habitat for HumanityEIN 73-1305668 | Community Development | OK | $10,160,701Mid-sized | 91.18 |
| Centre Pompidou FoundationEIN 13-2941675 | Arts, Culture, Humanities | CA | $7,552,193Mid-sized | 92.22 |
| Centro Legal De La RazaEIN 23-7181456 | Human and Civil Rights | CA | $5,659,231Mid-sized | 92.22 |
| Cerebral PalsyEIN 39-0901265 | Health | WI | $6,080,335Mid-sized | 88.99 |
| CETEIN 31-0560051 | Arts, Culture, Humanities | OH | $5,016,398Mid-sized | 84.20 |
| CFES Brilliant PathwaysEIN 22-3159630 | Education | NY | $3,564,584Mid-sized | 84.83 |
| Challenged Athletes FoundationEIN 33-0739596 | Human Services | CA | $8,869,120Mid-sized | 84.16 |
| Chamber Music Society of Lincoln CenterEIN 13-2628036 | Arts, Culture, Humanities | NY | $8,916,142Mid-sized | 91.66 |
| Charity CarsEIN 59-3362703 | Human Services | FL | $7,458,283Mid-sized | 94.74 |
| Charity MotorsEIN 38-3251827 | Human Services | MI | $6,804,600Mid-sized | 54.61 |
| Charity VisionEIN 77-0222786 | International | UT | $11,957,329Mid-sized | 96.66 |
| Charles H. Wright Museum of African American HistoryEIN 38-1882096 | Arts, Culture, Humanities | MI | $6,275,367Mid-sized | 82.26 |
| Charleston Animal SocietyEIN 57-6021863 | Animals | SC | $7,048,049Mid-sized | 94.16 |
| Charlotte BalletEIN 58-1314711 | Arts, Culture, Humanities | NC | $7,537,739Mid-sized | 93.80 |
| Charlotte Rescue MissionEIN 56-0571223 | Human Services | NC | $6,345,655Mid-sized | 87.26 |
| Charlotte Symphony OrchestraEIN 56-6011568 | Arts, Culture, Humanities | NC | $9,930,801Mid-sized | 76.92 |
| Charlottesville Free ClinicEIN 54-1610405 | Health | VA | $4,215,026Mid-sized | 89.71 |
| Charlottesville-Albemarle SPCAEIN 54-0595009 | Animals | VA | $3,518,707Mid-sized | 86.45 |
| Cheekwood Botanical Garden & Museum of ArtEIN 62-0627921 | Arts, Culture, Humanities | TN | $10,709,480Mid-sized | 96.66 |
| Cherry Street Mission MinistriesEIN 34-1133369 | Human Services | OH | $6,252,648Mid-sized | 83.69 |
| Chesapeake Bay Maritime MuseumEIN 23-7051889 | Arts, Culture, Humanities | MD | $4,451,861Mid-sized | 94.91 |
| Chesapeake Bay TrustEIN 52-1454182 | Environment | MD | $12,114,935Mid-sized | 97.23 |