| C.M. Russell MuseumEIN 81-6003526 | Arts, Culture, Humanities | MT | $3,813,246Mid-sized | 84.05 |
| Cadence InternationalEIN 84-6027655 | Religion | CO | $9,231,613Mid-sized | 87.68 |
| California Center for the Arts, EscondidoEIN 33-0646517 | Arts, Culture, Humanities | CA | $5,002,152Mid-sized | 73.11 |
| California Film InstituteEIN 94-2498062 | Arts, Culture, Humanities | CA | $4,774,934Mid-sized | 77.25 |
| California Highway Patrol 11-99 FoundationEIN 95-6530738 | Human Services | CA | $4,292,243Mid-sized | 81.31 |
| California Shakespeare TheaterEIN 51-0169452 | Arts, Culture, Humanities | CA | $5,640,851Mid-sized | 88.42 |
| California State Parks FoundationEIN 94-1707583 | Environment | CA | $8,274,117Mid-sized | 75.25 |
| California TroutEIN 23-7097680 | Environment | CA | $5,896,349Mid-sized | 90.63 |
| California Waterfowl AssociationEIN 94-1149574 | Animals | CA | $10,714,120Mid-sized | 89.54 |
| California-Hawaii Elks Major ProjectEIN 95-1919366 | Human Services | CA | $4,289,759Mid-sized | 87.55 |
| Cambodian Children's FundEIN 20-0764162 | International | CA | $8,478,860Mid-sized | 91.16 |
| CAMC FoundationEIN 31-0887133 | Health | WV | $4,752,916Mid-sized | 87.52 |
| Camp Boggy CreekEIN 59-3012889 | Health | FL | $5,974,701Mid-sized | 85.15 |
| Camp Courageous of IowaEIN 23-7210932 | Health | IA | $6,518,726Mid-sized | 88.75 |
| Camp For AllEIN 76-0404267 | Health | TX | $4,641,381Mid-sized | 89.53 |
| Camp Good Days and Special TimesEIN 22-2329654 | Health | NY | $5,165,207Mid-sized | 92.22 |
| Camp Kesem NationalEIN 51-0454157 | Health | CA | $7,778,650Mid-sized | 94.69 |
| Camp KoreyEIN 20-3829742 | Health | WA | $4,884,551Mid-sized | 78.04 |
| Camp Sunshine, MaineEIN 22-2582877 | Health | ME | $3,598,067Mid-sized | 95.98 |
| Camp SweeneyEIN 75-6002547 | Health | TX | $4,039,809Mid-sized | 66.85 |
| Canal AllianceEIN 94-2832648 | Human Services | CA | $4,938,588Mid-sized | 90.95 |
| Cancer Support CommunityEIN 95-4163931 | Health | DC | $7,125,555Mid-sized | 96.66 |
| Cannon Memorial YMCAEIN 58-1574620 | Human Services | NC | $5,996,630Mid-sized | 95.02 |
| CAPA New HavenEIN 06-1625278 | Arts, Culture, Humanities | CT | $6,249,651Mid-sized | 88.90 |
| Capital Area United Way, LouisianaEIN 72-0447100 | Community Development | LA | $9,127,531Mid-sized | 93.42 |
| Capital Area United Way, MichiganEIN 38-1363572 | Community Development | MI | $3,844,560Mid-sized | 87.94 |
| Capital IDEAEIN 74-2893041 | Human Services | TX | $4,483,755Mid-sized | 89.99 |
| Capital Public RadioEIN 68-0223271 | Arts, Culture, Humanities | CA | $10,465,669Mid-sized | 87.78 |
| CaramoorEIN 13-5643627 | Arts, Culture, Humanities | NY | $7,027,427Mid-sized | 86.67 |
| Care NetEIN 54-1382723 | Human and Civil Rights | VA | $4,354,027Mid-sized | 92.66 |
| Careers through Culinary Arts Program (C-CAP)EIN 13-3662917 | Human Services | NY | $6,225,489Mid-sized | 85.90 |
| Caridad CenterEIN 65-0149423 | Human Services | FL | $4,141,825Mid-sized | 99.06 |
| CaringBridgeEIN 42-1529394 | Health | MN | $7,318,728Mid-sized | 81.08 |
| CaringWorksEIN 56-2370081 | Human Services | GA | $6,142,050Mid-sized | 90.94 |
| Caritas of AustinEIN 74-1909670 | Human Services | TX | $12,546,415Mid-sized | 87.34 |
| Carnegie Council for Ethics in International AffairsEIN 13-1573954 | International | NY | $3,528,670Mid-sized | 81.55 |
| Carolina BalletEIN 56-1445383 | Arts, Culture, Humanities | NC | $5,871,426Mid-sized | 89.69 |
| Cary Institute of Ecosystem StudiesEIN 22-3232968 | Research and Public Policy | NY | $13,031,409Mid-sized | 94.32 |
| Casa de AmparoEIN 95-3315571 | Human Services | CA | $8,748,510Mid-sized | 96.46 |
| Casa de Esperanza de Los NinosEIN 76-0105306 | Human Services | TX | $3,933,307Mid-sized | 89.53 |
| Casa de MarylandEIN 52-1372972 | Education | MD | $9,534,556Mid-sized | 83.76 |
| CASA of Los AngelesEIN 95-3890446 | Human Services | CA | $3,600,000Mid-sized | 80.49 |
| CASA of Travis CountyEIN 74-2369123 | Human Services | TX | $3,877,348Mid-sized | 91.53 |
| Cascade AIDS ProjectEIN 93-0903383 | Health | OR | $7,017,544Mid-sized | 86.00 |
| Cathedral KitchenEIN 22-3114500 | Human Services | NJ | $3,809,168Mid-sized | 98.23 |
| Catholic AnswersEIN 95-3754404 | Religion | CA | $7,475,369Mid-sized | 74.63 |
| Catholic Charities AtlantaEIN 58-1097003 | Human Services | GA | $5,894,054Mid-sized | 86.38 |
| Catholic Charities of Northern NevadaEIN 88-0339754 | Human Services | NV | $13,099,433Mid-sized | 91.45 |
| Catholic Charities of the Archdiocese of MilwaukeeEIN 39-0806321 | Human Services | WI | $6,103,750Mid-sized | 90.64 |
| Catholic Charities of the Archdiocese of Oklahoma CityEIN 73-0636561 | Human Services | OK | $8,014,721Mid-sized | 90.76 |
| Catholic Charities of the Archdiocese of OmahaEIN 47-0376612 | Human Services | NE | $5,110,419Mid-sized | 86.53 |
| Catholic Charities of the Diocese of FresnoEIN 94-1678938 | Human Services | CA | $5,994,629Mid-sized | 91.18 |
| Catholic Charities of the East BayEIN 94-2677202 | Human Services | CA | $6,682,589Mid-sized | 79.64 |
| Catholic Charities, Archdiocese of St. LouisEIN 43-0653270 | Human Services | MO | $7,104,722Mid-sized | 95.47 |
| Catholic Charities, Diocese of Venice, Inc.EIN 59-2473176 | Human Services | FL | $7,936,897Mid-sized | 90.71 |
| Catholic Community Services of Lane CountyEIN 93-0409105 | Human Services | OR | $4,582,187Mid-sized | 92.56 |
| Catholic Legal Immigration Network. Inc. (CLINIC)EIN 52-1584951 | Human and Civil Rights | MD | $6,944,953Mid-sized | 97.17 |
| Catholic Schools FoundationEIN 22-2485502 | Education | MA | $11,109,378Mid-sized | 96.08 |
| Catholic Social Services of AnchorageEIN 92-0037322 | Human Services | AK | $10,584,775Mid-sized | 93.25 |
| Catholic Social Services of ColumbusEIN 31-4379437 | Human Services | OH | $4,873,241Mid-sized | 96.10 |