| American Breast Cancer FoundationEIN 52-2031814 | Health | MD | $890,174Small | 73.76 |
| American Cancer SocietyEIN 13-1788491 | Health | GA | $879,276,674Large | 80.02 |
| American CinemathequeEIN 95-3902004 | Arts, Culture, Humanities | CA | $3,156,998Small | 77.32 |
| American Civil Liberties Union FoundationEIN 13-6213516 | Human and Civil Rights | NY | $115,464,165Large | 96.66 |
| American Civil Liberties Union Foundation of Northern CaliforniaEIN 94-0279770 | Human and Civil Rights | CA | $11,104,423Mid-sized | 87.28 |
| American Civil Liberties Union of Montana FoundationEIN 81-0445339 | Human and Civil Rights | MT | $789,427Small | 86.76 |
| American Civil Liberties Union of New Jersey FoundationEIN 22-2010593 | Human and Civil Rights | NJ | $1,839,463Small | 80.13 |
| American Civil Liberties Union of Ohio FoundationEIN 23-7137105 | Human and Civil Rights | OH | $1,661,948Small | 86.59 |
| American Committee for Shaare Zedek Medical Center In JerusalemEIN 13-5645878 | Health | NY | $20,966,439Large | 94.74 |
| American Committee for the Weizmann Institute of ScienceEIN 13-1623886 | Health | NY | $83,439,000Large | 90.96 |
| American Composers ForumEIN 23-7452688 | Arts, Culture, Humanities | MN | $1,550,517Small | 85.47 |
| American Composers OrchestraEIN 13-2838450 | Arts, Culture, Humanities | NY | $1,629,135Small | 88.39 |
| American Conservatory TheaterEIN 94-6135772 | Arts, Culture, Humanities | CA | $23,341,174Large | 89.42 |
| American Constitution Society for Law and PolicyEIN 52-2313694 | Research and Public Policy | DC | $5,891,120Mid-sized | 88.13 |
| American Council for an Energy-Efficient Economy EIN 94-2711707 | Research and Public Policy | DC | $9,400,072Mid-sized | 95.43 |
| American Council on GermanyEIN 13-1889074 | International | NY | $1,962,779Small | 93.12 |
| American Council on Science and HealthEIN 13-2911127 | Research and Public Policy | NY | $1,729,003Small | 86.87 |
| American Dance FestivalEIN 06-0932294 | Arts, Culture, Humanities | NC | $3,568,666Mid-sized | 87.64 |
| American DocumentaryEIN 13-3447752 | Arts, Culture, Humanities | NY | $4,013,582Mid-sized | 89.53 |
| American Eagle FoundationEIN 58-1652023 | Animals | TN | $1,807,117Small | 100.00 |
| American Enterprise Institute for Public Policy ResearchEIN 53-0218495 | Research and Public Policy | DC | $55,822,303Large | 87.22 |
| American Family AssociationEIN 64-0607275 | Human and Civil Rights | MS | $18,860,780Large | 90.91 |
| American Federation for Aging ResearchEIN 13-3045282 | Health | NY | $5,980,117Mid-sized | 92.92 |
| American Federation for Children Growth FundEIN 52-2111508 | Education | DC | $7,828,481Mid-sized | 83.70 |
| American Federation of Police and Concerned CitizensEIN 52-1127259 | Human Services | FL | $4,010,540Mid-sized | 70.02 |
| American Film InstituteEIN 52-6072925 | Arts, Culture, Humanities | CA | $30,818,470Large | 80.43 |
| American Folk Art MuseumEIN 13-1985627 | Arts, Culture, Humanities | NY | $4,220,031Mid-sized | 85.39 |
| American Forest FoundationEIN 52-1235124 | Environment | DC | $13,062,939Mid-sized | 96.39 |
| American ForestsEIN 53-0196544 | Environment | DC | $5,495,270Mid-sized | 86.81 |
| American Foundation For Children With AIDSEIN 30-0247823 | International | PA | $1,841,016Small | 87.96 |
| American Foundation for Suicide PreventionEIN 13-3393329 | Health | NY | $23,219,954Large | 89.12 |
| American Foundation for Surgery of the HandEIN 74-2428242 | Health | IL | $1,663,447Small | 90.87 |
| American Foundation for the BlindEIN 13-5562161 | Human Services | VA | $12,764,530Mid-sized | 84.99 |
| American Friends of ALYN HospitalEIN 13-6100833 | Health | NY | $3,113,775Small | 86.75 |
| American Friends of Ateret CohanimEIN 11-2706563 | Education | NY | $867,958Small | 54.97 |
| American Friends of Beit Issie ShapiroEIN 13-3434781 | Human Services | NY | $2,203,983Small | 84.82 |
| American Friends of Chabad of ThailandEIN 03-0498942 | Religion | NY | $1,386,468Small | 56.93 |
| American Friends of IDCEIN 31-1577589 | Education | NY | $19,778,201Large | 86.56 |
| American Friends of Kupat Ha'irEIN 20-1523797 | Human Services | NY | $6,536,406Mid-sized | 73.90 |
| American Friends of Leket IsraelEIN 20-8202424 | International | NJ | $5,856,154Mid-sized | 88.19 |
| American Friends of LubavitchEIN 52-2193738 | Religion | DC | $1,448,713Small | 44.41 |
| American Friends of Magen David AdomEIN 13-1790719 | Health | NY | $34,622,656Large | 85.50 |
| American Friends of Meir PanimEIN 20-1582478 | Human Services | NY | $5,126,089Mid-sized | 92.41 |
| American Friends of Migdal OhrEIN 13-3389558 | Human Services | NY | $5,992,863Mid-sized | 94.44 |
| American Friends of Museums in IsraelEIN 23-7443023 | Arts, Culture, Humanities | NY | $458,621Small | 66.19 |
| American Friends of Neve Shalom/Wahat al-SalamEIN 13-3441742 | International | CA | $492,665Small | 83.89 |
| American Friends of NishmatEIN 04-3106173 | Education | NY | $3,613,549Mid-sized | 92.22 |
| American Friends of Rabbinical College of TelzstoneEIN 13-3503955 | Religion | NJ | $16,039,770Large | 72.71 |
| American Friends of Shalva IsraelEIN 56-2676533 | Human Services | NY | $4,298,752Mid-sized | 87.30 |
| American Friends of the Episcopal Diocese of JerusalemEIN 59-6155008 | International | CT | $1,547,219Small | 95.73 |
| American Friends of the Hebrew UniversityEIN 13-1568923 | Education | NY | $60,923,877Large | 87.98 |
| American Friends of the Israel Democracy InstituteEIN 13-3348313 | International | GA | $8,396,726Mid-sized | 73.82 |
| American Friends of the Israel MuseumEIN 23-7182582 | Arts, Culture, Humanities | NY | $17,264,366Large | 85.11 |
| American Friends of the Israel National Museum of ScienceEIN 13-3329462 | Arts, Culture, Humanities | NY | $1,274,004Small | 84.82 |
| American Friends of the Israel Philharmonic OrchestraEIN 23-7183563 | Arts, Culture, Humanities | NY | $6,296,009Mid-sized | 86.19 |
| American Friends of the LouvreEIN 52-2376786 | Arts, Culture, Humanities | NY | $4,755,697Mid-sized | 92.02 |
| American Friends of the Open University of IsraelEIN 13-3091674 | Education | NY | $1,111,082Small | 84.69 |
| American Friends of The Tel Aviv UniversityEIN 13-1996126 | Education | NY | $36,078,234Large | 93.25 |
| American Friends of Yad EliezerEIN 11-3459952 | Human Services | NJ | $41,944,264Large | 94.69 |
| American Friends of Yeshivot Bnei AkivaEIN 52-6080692 | Education | NY | $688,740Small | 69.87 |