| Entertainment Industry FoundationEIN 95-1644609 | Health | CA | $61,723,094Large | 97.17 |
| EntrustEIN 54-1256309 | Religion | CO | $3,792,951Mid-sized | 93.47 |
| Environment America Research and Policy CenterEIN 13-4339865 | Environment | CO | $3,179,487Small | 83.13 |
| Environmental Advocates of New YorkEIN 22-2360736 | Environment | NY | $1,251,586Small | 99.79 |
| Environmental and Energy Study InstituteEIN 52-1268030 | Environment | DC | $1,296,571Small | 100.00 |
| Environmental Defense CenterEIN 77-0061994 | Environment | CA | $1,135,564Small | 90.57 |
| Environmental Grantmakers AssociationEIN 20-8817646 | Environment | NY | $2,539,563Small | 91.44 |
| Environmental Health CoalitionEIN 95-3798792 | Environment | CA | $3,829,007Mid-sized | 86.60 |
| Environmental InitiativeEIN 41-1718834 | Environment | MN | $2,064,185Small | 96.07 |
| Environmental Integrity ProjectEIN 20-1326922 | Environment | DC | $3,168,637Small | 84.42 |
| Environmental Investigation AgencyEIN 52-1654284 | Environment | DC | $4,791,938Mid-sized | 89.39 |
| Environmental Law Alliance WorldwideEIN 94-3116602 | Environment | OR | $1,816,495Small | 95.34 |
| Environmental Law and Policy CenterEIN 36-3866530 | Environment | IL | $6,344,275Mid-sized | 93.30 |
| Environmental Law InstituteEIN 52-0901863 | Environment | DC | $5,604,514Mid-sized | 92.44 |
| Environmental Research and Education FoundationEIN 52-1804051 | Environment | NC | $2,511,072Small | 95.50 |
| Environmental Traveling CompanionsEIN 51-0158789 | Human Services | CA | $1,111,244Small | 78.76 |
| Environmental Working GroupEIN 52-2148600 | Environment | DC | $9,318,340Mid-sized | 91.51 |
| EOD Warrior FoundationEIN 20-8618412 | Human Services | FL | $1,378,932Small | 92.02 |
| Epic AcademyEIN 20-8674711 | Education | IL | $5,660,374Mid-sized | 80.90 |
| Epilepsy Foundation of MinnesotaEIN 41-0874541 | Health | MN | $2,228,406Small | 87.22 |
| Epilepsy Foundation of TexasEIN 74-2141084 | Health | TX | $2,624,467Small | 89.60 |
| Epiphany SchoolEIN 04-3391788 | Education | MA | $4,014,326Mid-sized | 83.21 |
| Episcopal Charities of the Diocese of New YorkEIN 13-3902908 | Human Services | NY | $1,785,346Small | 86.42 |
| Episcopal Church FoundationEIN 13-1776448 | Religion | NY | $4,278,329Mid-sized | 86.61 |
| Episcopal Relief & DevelopmentEIN 73-1635264 | International | NY | $21,968,901Large | 91.01 |
| Epworth Children's HomeEIN 57-0314389 | Human Services | SC | $6,948,186Mid-sized | 94.72 |
| Equal Justice AmericaEIN 13-3708596 | Human and Civil Rights | VA | $1,109,390Small | 73.99 |
| Equal Justice InitiativeEIN 63-1135091 | Human and Civil Rights | AL | $5,690,202Mid-sized | 100.00 |
| Equal Justice WorksEIN 52-1469738 | Human and Civil Rights | DC | $17,605,902Large | 90.17 |
| Equal Rights AdvocatesEIN 23-7217027 | Human and Civil Rights | CA | $1,623,252Small | 80.47 |
| Equality California InstituteEIN 68-0438008 | Human and Civil Rights | CA | $1,960,521Small | 90.71 |
| Equality Florida InstituteEIN 59-3435235 | Human and Civil Rights | FL | $2,652,749Small | 92.03 |
| Equality NowEIN 13-3660566 | International | NY | $4,916,223Mid-sized | 94.13 |
| EquestEIN 75-1823701 | Human Services | TX | $1,784,585Small | 85.71 |
| Equine AdvocatesEIN 11-3313534 | Animals | NY | $1,445,721Small | 87.52 |
| EQUIPEIN 33-0686464 | Religion | GA | $4,149,515Mid-sized | 80.95 |
| Eric Carle Museum of Picture Book ArtEIN 04-3542086 | Arts, Culture, Humanities | MA | $3,180,878Small | 84.43 |
| Erie City MissionEIN 25-0987217 | Human Services | PA | $3,760,099Mid-sized | 86.08 |
| Erie Community FoundationEIN 25-6032032 | Community Development | PA | $20,998,824Large | 96.64 |
| ESCAPE Family Resource CenterEIN 76-0029184 | Human Services | TX | $1,330,222Small | 75.99 |
| Española HumaneEIN 85-0406234 | Animals | NM | $1,802,326Small | 91.91 |
| EsperançaEIN 23-7087997 | International | AZ | $3,551,448Mid-sized | 94.64 |
| Esperanza International FoundationEIN 91-1585511 | International | TX | $1,325,567Small | 82.43 |
| Ethics and Public Policy CenterEIN 52-1162185 | Research and Public Policy | DC | $3,827,567Mid-sized | 89.98 |
| eTownEIN 84-1186181 | Arts, Culture, Humanities | CO | $2,265,458Small | 88.49 |
| ETV Endowment of South CarolinaEIN 57-0657549 | Arts, Culture, Humanities | SC | $7,062,134Mid-sized | 96.42 |
| Eugene MissionEIN 93-0563797 | Human Services | OR | $5,509,715Mid-sized | 84.44 |
| Eva's Village, Inc.EIN 22-2424542 | Human Services | NJ | $11,009,934Mid-sized | 95.49 |
| Evangelism Missions Inc.EIN 59-1712184 | Religion | AL | $624,514Small | 58.32 |
| Evangelistic Outreach MinistriesEIN 23-7299935 | Religion | OH | $1,273,615Small | 73.32 |
| Evans Scholars FoundationEIN 36-2518129 | Education | IL | $27,629,028Large | 92.67 |
| Evansville MuseumEIN 35-0874517 | Arts, Culture, Humanities | IN | $2,213,959Small | 83.28 |
| Evansville Rescue MissionEIN 35-0942622 | Human Services | IN | $4,336,522Mid-sized | 88.58 |
| EvanTellEIN 23-7281987 | Religion | TX | $1,398,742Small | 83.52 |
| Everett Gospel MissionEIN 91-0780146 | Human Services | WA | $4,707,627Mid-sized | 84.76 |
| Everglades FoundationEIN 59-3228899 | Environment | FL | $8,149,416Mid-sized | 91.03 |
| Every Generation MinistriesEIN 84-1253004 | Religion | CA | $1,554,915Small | 90.43 |
| Every VillageEIN 76-0653562 | Religion | TX | $1,915,433Small | 84.15 |
| Every Voice CenterEIN 52-2003442 | Human and Civil Rights | DC | $2,340,028Small | 83.86 |
| Everytown for Gun Safety Support FundEIN 26-1598353 | Research and Public Policy | NY | $15,515,941Large | 76.39 |