| The Seattle Public Library FoundationEIN 91-1140642 | Arts, Culture, Humanities | WA | $5,750,770Mid-sized | 96.11 |
| The Second StepEIN 22-2868513 | Human Services | MA | $1,830,231Small | 81.36 |
| The SEED FoundationEIN 54-1850819 | Education | DC | $5,472,657Mid-sized | 89.48 |
| The Seeing EyeEIN 22-1539721 | Animals | NJ | $27,150,791Large | 85.82 |
| The Senior SourceEIN 75-1085555 | Human Services | TX | $6,613,663Mid-sized | 94.72 |
| The Sentencing ProjectEIN 52-1472546 | Human and Civil Rights | DC | $1,485,974Small | 92.20 |
| The SentryEIN 20-8827879 | International | DC | $2,861,789Small | 89.39 |
| The Shade TreeEIN 88-0253276 | Human Services | NV | $3,411,140Small | 89.89 |
| The Shakespeare Theatre of New JerseyEIN 22-1962163 | Arts, Culture, Humanities | NJ | $4,083,714Mid-sized | 87.14 |
| The Shalom Hartman Institute of North AmericaEIN 13-3014387 | Education | NY | $16,313,890Large | 91.51 |
| The Sharing CenterEIN 59-2744535 | Human Services | FL | $3,997,342Mid-sized | 88.85 |
| The Shawn Carter FoundationEIN 11-3662240 | Education | FL | $832,035Small | 78.20 |
| The Shea Center for Therapeutic RidingEIN 95-3351363 | Health | CA | $3,757,858Mid-sized | 89.18 |
| The SheepfoldEIN 95-3426900 | Human Services | CA | $2,577,494Small | 87.25 |
| The Sheldon Arts FoundationEIN 43-1489756 | Arts, Culture, Humanities | MO | $3,282,775Small | 89.73 |
| The Shelter for Abused Women & ChildrenEIN 59-2752895 | Human Services | FL | $4,627,473Mid-sized | 90.57 |
| The Sikh CoalitionEIN 22-3834037 | Human and Civil Rights | NY | $1,580,818Small | 89.79 |
| The Society of St. AndrewEIN 54-1285793 | Human Services | VA | $15,925,960Large | 87.66 |
| The Society of St. Vincent de Paul GeorgiaEIN 58-0967972 | Human Services | GA | $15,390,829Large | 89.52 |
| The Society of St. Vincent de Paul in CincinnatiEIN 31-0537510 | Human Services | OH | $7,726,846Mid-sized | 97.04 |
| The Source for WomenEIN 76-0025661 | Health | TX | $1,488,827Small | 86.75 |
| The South Carolina Historical SocietyEIN 57-0323800 | Arts, Culture, Humanities | SC | $950,748Small | 84.84 |
| The Southern Education FoundationEIN 13-5562388 | Education | GA | $4,278,245Mid-sized | 91.90 |
| The SPCA for Monterey CountyEIN 94-1167409 | Animals | CA | $7,541,598Mid-sized | 92.83 |
| The Speed Art MuseumEIN 61-0444823 | Arts, Culture, Humanities | KY | $11,192,532Mid-sized | 95.91 |
| The Sphinx OrganizationEIN 38-3283759 | Arts, Culture, Humanities | MI | $5,008,617Mid-sized | 85.61 |
| The Spring of Tampa BayEIN 59-1777135 | Human Services | FL | $4,256,840Mid-sized | 89.55 |
| The Station of the CrossEIN 16-1511190 | Religion | NY | $1,167,277Small | 65.15 |
| The Steppingstone FoundationEIN 04-3086666 | Education | MA | $4,848,517Mid-sized | 81.68 |
| The Street TrustEIN 93-1057956 | Environment | OR | $1,059,610Small | 74.03 |
| The Stride CenterEIN 94-3333571 | Human Services | CA | $1,940,006Small | 78.84 |
| The Sun Valley Center for the ArtsEIN 23-7113276 | Arts, Culture, Humanities | ID | $3,229,667Small | 87.30 |
| The Sunlight FoundationEIN 20-3903427 | Human and Civil Rights | DC | $1,451,359Small | 81.08 |
| The Sunshine Kids FoundationEIN 76-0020802 | Health | TX | $3,718,767Mid-sized | 97.48 |
| The Supreme Court Historical SocietyEIN 23-7420574 | Arts, Culture, Humanities | DC | $2,694,765Small | 82.95 |
| The TEAK FellowshipEIN 13-4011465 | Education | NY | $2,346,041Small | 92.46 |
| The Tech Museum of InnovationEIN 94-2864660 | Arts, Culture, Humanities | CA | $19,542,724Large | 94.26 |
| The THANC FoundationEIN 80-0062118 | Health | NY | $1,981,338Small | 87.04 |
| The Tibet FundEIN 13-3115145 | International | NY | $6,863,561Mid-sized | 97.12 |
| The Toledo ZooEIN 34-4440256 | Animals | OH | $32,785,728Large | 92.16 |
| The Tony Robbins FoundationEIN 33-0492446 | Human Services | CA | $4,603,367Mid-sized | 92.24 |
| The Trevor ProjectEIN 95-4681287 | Human and Civil Rights | CA | $6,686,579Mid-sized | 93.84 |
| The Tribe ClubEIN 54-6056480 | Education | VA | $6,675,496Mid-sized | 80.90 |
| The Trinity ForumEIN 54-1612640 | Education | DC | $1,119,991Small | 86.40 |
| The Tulsa Symphony OrchestraEIN 20-3798077 | Arts, Culture, Humanities | OK | $2,164,852Small | 86.90 |
| The Tundra Women's CoalitionEIN 92-0068684 | Human Services | AK | $2,678,290Small | 79.79 |
| The Ulman Cancer Fund for Young AdultsEIN 52-2057636 | Health | MD | $2,454,766Small | 86.10 |
| The United Way of Amarillo & CanyonEIN 75-0800600 | Community Development | TX | $4,858,845Mid-sized | 85.52 |
| The United Way of Clark, Champaign and Madison Counties OhioEIN 31-0549095 | Community Development | OH | $1,439,544Small | 89.33 |
| The United Way of Greater WaterburyEIN 06-0646634 | Community Development | CT | $4,589,443Mid-sized | 90.71 |
| The United Way of Okaloosa & Walton CountiesEIN 59-0972293 | Community Development | FL | $1,129,114Small | 91.70 |
| The United Way of Southwestern PennsylvaniaEIN 25-1043578 | Community Development | PA | $37,508,330Large | 93.98 |
| The United Way of Youngstown and the Mahoning ValleyEIN 34-0714598 | Community Development | OH | $2,061,649Small | 94.05 |
| The Urban AlternativeEIN 75-1835253 | Religion | TX | $11,099,552Mid-sized | 86.59 |
| The Urban Ministry CenterEIN 56-1837620 | Human Services | NC | $5,791,641Mid-sized | 94.07 |
| The V FoundationEIN 13-3705951 | Health | NC | $27,693,120Large | 94.69 |
| The Valentine Richmond History CenterEIN 54-0505967 | Arts, Culture, Humanities | VA | $2,787,806Small | 88.94 |
| The Valentine TheatreEIN 34-1385037 | Arts, Culture, Humanities | OH | $1,642,428Small | 80.66 |
| The Valerie FundEIN 22-2126867 | Health | NJ | $4,949,013Mid-sized | 93.88 |
| The Voter Participation CenterEIN 55-0889748 | Human and Civil Rights | DC | $6,322,992Mid-sized | 76.59 |