| The Crystal Charity BallEIN 75-6035893 | Human Services | TX | $6,021,474Mid-sized | 86.56 |
| The CT ChallengeEIN 20-2777748 | Health | CT | $2,300,611Small | 78.64 |
| The Cummer Museum of Art & GardensEIN 59-2191587 | Arts, Culture, Humanities | FL | $4,800,748Mid-sized | 86.34 |
| The Dallas Arboretum and Botanical SocietyEIN 23-7375815 | Environment | TX | $24,493,663Large | 92.50 |
| The Dallas OperaEIN 75-6004746 | Arts, Culture, Humanities | TX | $18,462,712Large | 92.71 |
| The Damien CenterEIN 35-1711878 | Health | IN | $4,390,557Mid-sized | 91.14 |
| The David ProjectEIN 16-1616489 | Education | MA | $2,618,014Small | 78.88 |
| The David Sheldrick Wildlife Trust USAEIN 30-0224549 | Animals | CA | $5,248,475Mid-sized | 96.46 |
| The Dawson McAllister AssociationEIN 20-1198064 | Religion | TN | $2,193,321Small | 77.00 |
| The Dayton FoundationEIN 31-6027287 | Community Development | OH | $27,126,725Large | 83.65 |
| The Delaware Symphony OrchestraEIN 51-6017449 | Arts, Culture, Humanities | DE | $1,645,578Small | 87.75 |
| The Denver FoundationEIN 84-6048381 | Community Development | CO | $81,071,246Large | 90.42 |
| The Detroit Institute for ChildrenEIN 38-1359511 | Human Services | MI | $2,624,067Small | 85.57 |
| The Detroit Institute of ArtsEIN 38-1359510 | Arts, Culture, Humanities | MI | $40,056,968Large | 89.52 |
| The Dictionary ProjectEIN 57-1029802 | Education | SC | $4,276,550Mid-sized | 75.68 |
| The Dixon Gallery and GardensEIN 62-0943809 | Arts, Culture, Humanities | TN | $5,237,638Mid-sized | 84.04 |
| The DoorwaysEIN 54-1240348 | Health | VA | $2,502,321Small | 96.17 |
| The DoseumEIN 74-2659746 | Arts, Culture, Humanities | TX | $8,263,318Mid-sized | 92.02 |
| The Dougy CenterEIN 93-0833241 | Human Services | OR | $1,868,201Small | 85.69 |
| The Drake HouseEIN 20-0943038 | Human Services | GA | $1,097,402Small | 90.94 |
| The Drawing CenterEIN 13-2887872 | Arts, Culture, Humanities | NY | $2,272,751Small | 81.16 |
| The Dream CorpsEIN 26-1140201 | Human and Civil Rights | CA | $5,326,354Mid-sized | 81.07 |
| The East Harlem School at Exodus HouseEIN 13-3738559 | Education | NY | $2,907,449Small | 93.38 |
| The Edible Schoolyard ProjectEIN 94-3248671 | Education | CA | $2,100,818Small | 84.93 |
| The Education Foundation of Collier CountyEIN 65-0230582 | Education | FL | $2,224,265Small | 97.14 |
| The Education FundEIN 59-2468114 | Education | FL | $2,612,408Small | 86.44 |
| The Educational AllianceEIN 13-5562210 | Human Services | NY | $41,828,233Large | 91.75 |
| The Elaine Clark CenterEIN 58-1079411 | Human Services | GA | $948,317Small | 82.10 |
| The Elephant SanctuaryEIN 62-1587327 | Animals | TN | $4,982,174Mid-sized | 98.75 |
| The Ellington Fund EIN 52-1152273 | Arts, Culture, Humanities | DC | $1,790,367Small | 74.64 |
| The Empty Stocking FundEIN 23-7159125 | Human Services | GA | $1,124,541Small | 87.70 |
| The Ensemble TheaterEIN 74-1941943 | Arts, Culture, Humanities | TX | $2,057,626Small | 77.17 |
| The Equal Rights CenterEIN 52-1297949 | Human and Civil Rights | DC | $1,268,339Small | 77.75 |
| The European InstituteEIN 52-1627721 | International | DC | $795,173Small | 58.41 |
| The Exchange Club Family Center of the Mid-SouthEIN 58-1502697 | Human Services | TN | $2,181,701Small | 82.00 |
| The Explorers ClubEIN 13-1866795 | Arts, Culture, Humanities | NY | $2,454,020Small | 82.53 |
| The Fabric Workshop and MuseumEIN 23-2018929 | Arts, Culture, Humanities | PA | $2,737,279Small | 83.91 |
| The Family CenterEIN 58-0828094 | Human Services | GA | $1,239,064Small | 85.38 |
| The Family ConservancyEIN 44-0454800 | Human Services | KS | $13,903,035Large | 87.04 |
| The Family FoundationEIN 52-1425355 | Research and Public Policy | VA | $1,066,485Small | 75.69 |
| The Family Pantry of Cape CodEIN 22-3079904 | Human Services | MA | $2,601,689Small | 81.58 |
| The Family PlaceEIN 75-1590896 | Human Services | TX | $13,069,089Mid-sized | 91.17 |
| The Family Radio Network, Inc.EIN 39-1280969 | Religion | WI | $1,513,177Small | 92.99 |
| The Family TreeEIN 52-1110645 | Human Services | MD | $3,155,863Small | 92.41 |
| The Farm SchoolEIN 22-2959081 | Education | MA | $1,772,558Small | 86.10 |
| The Federalist Society for Law and Public Policy StudiesEIN 36-3235550 | Research and Public Policy | DC | $18,233,577Large | 92.22 |
| The Federation, Jewish Communities of Western ConnecticutEIN 06-0646691 | Community Development | CT | $1,014,890Small | 85.85 |
| The Fellowship of ReconciliationEIN 13-3792144 | International | NY | $1,087,847Small | 72.99 |
| The FieldEIN 13-3357408 | Arts, Culture, Humanities | NY | $2,808,891Small | 85.85 |
| The Field MuseumEIN 36-2167011 | Arts, Culture, Humanities | IL | $80,404,720Large | 90.93 |
| The Film FoundationEIN 95-4244945 | Arts, Culture, Humanities | CA | $1,887,025Small | 75.31 |
| The Filson Historical SocietyEIN 61-0444690 | Arts, Culture, Humanities | KY | $2,690,373Small | 84.18 |
| The First Tee Metropolitan New YorkEIN 31-1724122 | Human Services | NY | $3,938,992Mid-sized | 82.96 |
| The First Tee of ConnecticutEIN 06-1510744 | Human Services | CT | $961,506Small | 72.51 |
| The Flea TheaterEIN 13-3904262 | Arts, Culture, Humanities | NY | $1,692,384Small | 86.38 |
| The Florence ProjectEIN 86-0658103 | Human and Civil Rights | AZ | $4,451,296Mid-sized | 89.16 |
| The Florida AquariumEIN 59-2807815 | Animals | FL | $18,265,885Large | 90.00 |
| The Florida Bar FoundationEIN 59-1004604 | Human and Civil Rights | FL | $13,470,190Mid-sized | 79.94 |
| The Florida OrchestraEIN 59-1223691 | Arts, Culture, Humanities | FL | $10,882,617Mid-sized | 89.92 |
| The Food Bank for Central & Northeast MissouriEIN 43-1238934 | Human Services | MO | $58,016,683Large | 89.63 |