| South Dakota Symphony OrchestraEIN 46-6017026 | Arts, Culture, Humanities | SD | $1,927,737Small | 83.34 |
| South Florida MuseumEIN 59-0598726 | Arts, Culture, Humanities | FL | $3,401,335Small | 87.76 |
| South Florida PBSEIN 59-0737868 | Arts, Culture, Humanities | FL | $18,553,742Large | 78.65 |
| South Florida Science Center and AquariumEIN 59-0915177 | Arts, Culture, Humanities | FL | $3,583,072Mid-sized | 90.59 |
| South Florida Wildlife CenterEIN 23-7086391 | Animals | FL | $3,713,493Mid-sized | 78.77 |
| South Hills Interfaith MovementEIN 25-1213332 | Human Services | PA | $2,330,337Small | 88.07 |
| South Plains Food BankEIN 75-1904829 | Human Services | TX | $15,594,953Large | 90.67 |
| South Shore Habitat for HumanityEIN 22-2701789 | Community Development | MA | $2,438,899Small | 94.69 |
| South Street Seaport MuseumEIN 13-2596500 | Arts, Culture, Humanities | NY | $3,179,707Small | 82.13 |
| Southeast Alaska Conservation CouncilEIN 92-0062992 | Environment | AK | $589,607Small | 82.59 |
| Southeast Missouri Food BankEIN 43-1395863 | Human Services | MO | $16,120,107Large | 97.17 |
| Southeastern Children's HomeEIN 23-7061916 | Human Services | SC | $1,045,679Small | 89.15 |
| Southeastern Guide DogsEIN 59-2252352 | Animals | FL | $9,239,038Mid-sized | 95.32 |
| Southeastern Legal FoundationEIN 58-1247027 | Human and Civil Rights | GA | $3,057,517Small | 88.92 |
| Southern California Public RadioEIN 95-4765734 | Arts, Culture, Humanities | CA | $27,593,781Large | 85.94 |
| Southern Center for Human RightsEIN 62-1025326 | Human and Civil Rights | GA | $2,747,262Small | 99.34 |
| Southern Center for International StudiesEIN 58-1285654 | International | GA | $978,904Small | 81.80 |
| Southern Environmental Law CenterEIN 52-1436778 | Environment | VA | $26,551,471Large | 100.00 |
| Southern Minnesota Initiative FoundationEIN 36-3454285 | Community Development | MN | $4,891,201Mid-sized | 92.20 |
| Southern Oregon Humane SocietyEIN 93-0391640 | Animals | OR | $893,883Small | 95.57 |
| Southern Partners FundEIN 58-2409301 | Human Services | GA | $1,225,922Small | 77.64 |
| Southern Poverty Law CenterEIN 63-0598743 | Human and Civil Rights | AL | $59,784,321Large | 88.78 |
| Southern Scholarship FoundationEIN 59-0939481 | Education | FL | $1,950,039Small | 94.17 |
| Southern Utah Wilderness AllianceEIN 94-2936961 | Environment | UT | $2,658,079Small | 93.68 |
| Southside Early Childhood CenterEIN 43-0685348 | Human Services | MO | $2,611,208Small | 89.14 |
| Southwest Autism Research & Resource CenterEIN 31-1496646 | Health | AZ | $10,419,604Mid-sized | 92.02 |
| Southwest Center for HIV/AIDSEIN 86-0695862 | Health | AZ | $3,377,818Small | 86.42 |
| Southwest Christian CareEIN 58-1849504 | Human Services | GA | $2,109,260Small | 73.34 |
| Southwest School of ArtEIN 74-6068932 | Education | TX | $5,289,868Mid-sized | 84.25 |
| SOZO InternationalEIN 20-0166014 | International | CO | $1,452,252Small | 86.00 |
| SPARKEIN 54-1498824 | Education | VA | $4,425,085Mid-sized | 78.96 |
| Spartanburg Humane SocietyEIN 57-0481019 | Animals | SC | $1,598,762Small | 81.52 |
| Spay-Neuter Assistance Program, Inc.EIN 76-0608925 | Animals | TX | $5,557,041Mid-sized | 73.07 |
| SPCA CincinnatiEIN 31-0543284 | Animals | OH | $6,230,961Mid-sized | 96.13 |
| SPCA InternationalEIN 87-0773320 | Animals | NY | $14,673,812Large | 72.62 |
| SPCA of Anne Arundel CountyEIN 52-0609154 | Animals | MD | $1,645,867Small | 95.00 |
| SPCA of Luzerne CountyEIN 24-0855811 | Animals | PA | $1,218,527Small | 80.67 |
| SPCA of TexasEIN 75-1216660 | Animals | TX | $18,553,754Large | 95.77 |
| SPCA of Wake CountyEIN 56-0891732 | Animals | NC | $2,819,747Small | 86.57 |
| SPCA of WestchesterEIN 13-1740069 | Animals | NY | $2,832,609Small | 100.00 |
| SPCA Serving Erie CountyEIN 16-0425315 | Animals | NY | $6,268,446Mid-sized | 86.67 |
| SPCA Tampa BayEIN 59-0715928 | Animals | FL | $5,909,487Mid-sized | 82.57 |
| spcaLAEIN 95-1738153 | Animals | CA | $7,647,760Mid-sized | 85.75 |
| Special K RanchEIN 36-3378581 | Human Services | MT | $1,872,180Small | 90.04 |
| Special OlympicsEIN 52-0889518 | Human Services | DC | $110,965,732Large | 90.49 |
| Special Olympics ChicagoEIN 23-7026774 | Human Services | IL | $1,938,952Small | 69.94 |
| Special Olympics ConnecticutEIN 23-7099756 | Human Services | CT | $5,001,707Mid-sized | 87.93 |
| Special Olympics DelawareEIN 23-7162877 | Human Services | DE | $1,795,879Small | 88.10 |
| Special Olympics FloridaEIN 23-7181560 | Human Services | FL | $13,729,105Large | 92.61 |
| Special Olympics GeorgiaEIN 23-7201676 | Human Services | GA | $3,924,681Mid-sized | 87.01 |
| Special Olympics HawaiiEIN 23-7173957 | Human Services | HI | $2,490,312Small | 92.65 |
| Special Olympics IdahoEIN 23-7185185 | Human Services | ID | $789,375Small | 78.93 |
| Special Olympics IllinoisEIN 36-2922811 | Human Services | IL | $9,727,839Mid-sized | 93.81 |
| Special Olympics IndianaEIN 35-1262574 | Human Services | IN | $4,170,414Mid-sized | 90.61 |
| Special Olympics IowaEIN 51-0176029 | Human Services | IA | $2,539,940Small | 83.25 |
| Special Olympics LouisianaEIN 72-0706608 | Human Services | LA | $1,807,182Small | 76.42 |
| Special Olympics MaineEIN 01-0355822 | Human Services | ME | $1,238,463Small | 83.42 |
| Special Olympics MarylandEIN 23-7089144 | Human Services | MD | $4,631,154Mid-sized | 89.88 |
| Special Olympics MassachusettsEIN 23-7242294 | Human Services | MA | $4,403,489Mid-sized | 82.89 |
| Special Olympics MinnesotaEIN 41-1228157 | Human Services | MN | $6,699,150Mid-sized | 87.44 |