| Champaign County Humane SocietyEIN 37-0714217 | Animals | IL | $1,058,761Small | 85.28 |
| Charcot-Marie-Tooth AssociationEIN 22-2480896 | Health | PA | $2,539,687Small | 87.39 |
| Charles H. Wright Museum of African American HistoryEIN 38-1882096 | Arts, Culture, Humanities | MI | $6,275,367Mid-sized | 82.26 |
| Charleston Symphony OrchestraEIN 57-6000192 | Arts, Culture, Humanities | SC | $3,490,071Small | 89.02 |
| Charleston Wine + Food FestivalEIN 20-2671674 | Arts, Culture, Humanities | SC | $3,135,643Small | 85.49 |
| Charlotte Rescue MissionEIN 56-0571223 | Human Services | NC | $6,345,655Mid-sized | 87.26 |
| Charlottesville Free ClinicEIN 54-1610405 | Health | VA | $4,215,026Mid-sized | 89.71 |
| Charlottesville-Albemarle SPCAEIN 54-0595009 | Animals | VA | $3,518,707Mid-sized | 86.45 |
| Chattanooga Symphony & OperaEIN 62-6002098 | Arts, Culture, Humanities | TN | $2,521,056Small | 87.15 |
| Cherry Creek Arts FestivalEIN 74-2546811 | Arts, Culture, Humanities | CO | $2,530,675Small | 84.55 |
| Cherry Street Mission MinistriesEIN 34-1133369 | Human Services | OH | $6,252,648Mid-sized | 83.69 |
| Chess in the SchoolsEIN 13-6119036 | Education | NY | $2,849,813Small | 84.95 |
| CHEST FoundationEIN 36-3286520 | Health | IL | $1,575,560Small | 89.58 |
| Chicago Academy of Sciences / Peggy Notebaert Nature MuseumEIN 36-0895575 | Arts, Culture, Humanities | IL | $6,434,381Mid-sized | 87.59 |
| Chicago Arts Partnerships in EducationEIN 36-3969334 | Education | IL | $1,393,218Small | 81.00 |
| Chicago Bar FoundationEIN 36-6109584 | Human and Civil Rights | IL | $4,461,315Mid-sized | 88.90 |
| Chicago Botanic GardenEIN 36-2225482 | Environment | IL | $48,755,048Large | 88.85 |
| Chicago Children's ChoirEIN 51-0140419 | Education | IL | $4,025,337Mid-sized | 82.63 |
| Chicago Children's MuseumEIN 36-3162484 | Arts, Culture, Humanities | IL | $7,043,221Mid-sized | 81.00 |
| Chicago Gateway GreenEIN 36-3764084 | Environment | IL | $618,570Small | 82.05 |
| Chicago Hope AcademyEIN 36-4244054 | Education | IL | $4,257,955Mid-sized | 84.66 |
| Chicago Humanities FestivalEIN 36-7148236 | Arts, Culture, Humanities | IL | $3,736,155Mid-sized | 83.39 |
| Chicago Lawyers' Committee for Civil Rights Under LawEIN 51-0189264 | Human and Civil Rights | IL | $2,101,380Small | 86.04 |
| Chicago Legal ClinicEIN 36-3200465 | Human and Civil Rights | IL | $2,536,631Small | 88.29 |
| Chicago Public MediaEIN 36-3687394 | Arts, Culture, Humanities | IL | $24,050,416Large | 83.37 |
| Chicago Symphony OrchestraEIN 36-2167823 | Arts, Culture, Humanities | IL | $79,669,618Large | 83.61 |
| Chicago Volunteer Legal ServicesEIN 23-7164989 | Human and Civil Rights | IL | $2,503,172Small | 82.20 |
| Chicago Youth CentersEIN 36-2344429 | Human Services | IL | $8,586,171Mid-sized | 87.30 |
| Chicago Zoological SocietyEIN 36-2167016 | Animals | IL | $73,409,870Large | 86.85 |
| Child Abuse NetworkEIN 73-1325326 | Human Services | OK | $1,356,882Small | 88.33 |
| Child Advocates San AntonioEIN 74-2494625 | Human Services | TX | $2,830,590Small | 89.61 |
| Child Evangelism FellowshipEIN 38-6091187 | Religion | MO | $16,705,310Large | 82.62 |
| Childcare ResourcesEIN 63-0882628 | Human Services | AL | $1,578,818Small | 83.43 |
| Childcare WorldwideEIN 95-3619910 | International | WA | $4,182,917Mid-sized | 85.01 |
| ChildFund InternationalEIN 54-0536100 | International | VA | $198,375,886Large | 81.59 |
| ChildhelpEIN 95-2884608 | Human Services | AZ | $39,767,034Large | 85.77 |
| Children in CrisisEIN 65-1196220 | Human Services | FL | $1,960,160Small | 89.38 |
| Children InternationalEIN 44-6005794 | International | MO | $137,699,672Large | 87.62 |
| Children of Bellevue, Inc.EIN 13-1679615 | Health | NY | $1,304,234Small | 81.18 |
| Children of PromiseEIN 36-4490602 | International | IN | $2,001,188Small | 86.56 |
| Children's AidEIN 13-5562191 | Human Services | NY | $130,688,819Large | 86.93 |
| Children's AllianceEIN 91-0982879 | Research and Public Policy | WA | $1,472,482Small | 82.23 |
| Children's Cancer AssociationEIN 93-1181662 | Health | OR | $4,563,802Mid-sized | 82.81 |
| Children's Cancer Research FundEIN 41-1893645 | Health | MN | $12,733,452Mid-sized | 81.03 |
| Children's CupEIN 42-1385361 | International | TX | $5,837,843Mid-sized | 81.13 |
| Children's Defense FundEIN 52-0895622 | Human Services | DC | $19,117,496Large | 84.09 |
| Children's Dream FundEIN 59-2145821 | Health | FL | $1,233,106Small | 88.58 |
| Children's FundEIN 33-0193286 | Human Services | CA | $4,099,530Mid-sized | 87.70 |
| Children's HarborEIN 57-0892070 | Health | AL | $4,506,020Mid-sized | 82.52 |
| Children's HeartLinkEIN 41-1307457 | International | MN | $1,760,708Small | 81.03 |
| Children's Home Society of FloridaEIN 59-0192430 | Human Services | FL | $117,824,708Large | 85.01 |
| Children's Home, Inc.EIN 71-0356241 | Human Services | AR | $3,449,138Small | 85.27 |
| Children's HopeChestEIN 33-0430285 | International | CO | $7,410,372Mid-sized | 88.85 |
| Children's Hospital Guild AssociationEIN 91-1394056 | Health | WA | $16,109,649Large | 86.84 |
| Children's Hospital of Wisconsin FoundationEIN 39-1500075 | Health | WI | $30,317,764Large | 87.65 |
| Children's Miracle Network HospitalsEIN 87-0387205 | Health | UT | $44,054,370Large | 87.12 |
| Children's Museum of Denver at Marsico CampusEIN 84-0658142 | Arts, Culture, Humanities | CO | $6,549,972Mid-sized | 89.42 |
| Children's Museum of ManhattanEIN 13-2761376 | Arts, Culture, Humanities | NY | $6,228,084Mid-sized | 85.38 |
| Children's Museum of RichmondEIN 51-0220694 | Arts, Culture, Humanities | VA | $3,922,438Mid-sized | 88.62 |
| Children's Museum of TacomaEIN 94-3036465 | Arts, Culture, Humanities | WA | $2,267,632Small | 80.44 |