| D. James Kennedy MinistriesEIN 65-0496702 | Religion | FL | $4,790,042Mid-sized | 85.12 |
| Dakin Humane SocietyEIN 20-5318898 | Animals | MA | $3,483,198Small | 87.67 |
| Dalit Freedom NetworkEIN 41-2075995 | International | VA | $2,220,867Small | 80.83 |
| Dallas ContemporaryEIN 75-1575687 | Arts, Culture, Humanities | TX | $1,826,588Small | 87.23 |
| Dallas Holocaust MuseumEIN 75-2113723 | Arts, Culture, Humanities | TX | $3,316,399Small | 84.85 |
| Dallas Museum of ArtEIN 75-0808774 | Arts, Culture, Humanities | TX | $28,537,301Large | 81.64 |
| Dallas Theater CenterEIN 75-0959992 | Arts, Culture, Humanities | TX | $10,134,614Mid-sized | 81.30 |
| Dallas Zoological SocietyEIN 75-0964982 | Animals | TX | $12,677,533Mid-sized | 88.08 |
| Dance Theatre of HarlemEIN 13-2642091 | Arts, Culture, Humanities | NY | $5,536,736Mid-sized | 83.11 |
| Dance/USAEIN 52-1253457 | Arts, Culture, Humanities | DC | $2,307,036Small | 87.61 |
| Dane County Humane SocietyEIN 39-0806335 | Animals | WI | $3,719,068Mid-sized | 87.15 |
| DAPCEPEIN 38-2451827 | Education | MI | $2,229,825Small | 83.85 |
| Dare 2 Share MinistriesEIN 84-0504202 | Religion | CO | $3,524,068Mid-sized | 85.23 |
| Daughters of Charity Services of San AntonioEIN 74-6106876 | Human Services | TX | $6,688,924Mid-sized | 89.78 |
| Davis Phinney FoundationEIN 20-0813566 | Health | CO | $1,889,395Small | 89.37 |
| DaySpring VillaEIN 73-1474319 | Human Services | OK | $1,234,000Small | 84.00 |
| DaystarEIN 62-1244203 | Human Services | TN | $2,070,139Small | 85.73 |
| Dayton Art InstituteEIN 31-0537480 | Arts, Culture, Humanities | OH | $5,217,588Mid-sized | 84.58 |
| Dayton Masonic FoundationEIN 31-1385609 | Arts, Culture, Humanities | OH | $780,648Small | 80.86 |
| Dayton Performing Arts AllianceEIN 31-6000101 | Arts, Culture, Humanities | OH | $8,167,915Mid-sized | 83.97 |
| DEA Educational FoundationEIN 52-1922097 | Health | DC | $1,197,681Small | 81.54 |
| Defenders of Animal RightsEIN 52-1061126 | Animals | MD | $1,124,255Small | 83.40 |
| Delaware Art MuseumEIN 51-0065746 | Arts, Culture, Humanities | DE | $5,189,312Mid-sized | 87.68 |
| Delaware Humane AssociationEIN 51-0082499 | Animals | DE | $1,765,553Small | 88.10 |
| Delaware Museum of Natural HistoryEIN 51-0083535 | Arts, Culture, Humanities | DE | $2,423,622Small | 89.09 |
| Delaware Riverkeeper NetworkEIN 74-3255972 | Environment | PA | $2,931,825Small | 88.44 |
| Delaware Valley Golden Retriever RescueEIN 23-2775413 | Animals | PA | $1,370,710Small | 85.34 |
| Delta Waterfowl FoundationEIN 53-0259796 | Animals | ND | $9,628,880Mid-sized | 87.69 |
| Democracy Now!EIN 01-0708733 | Arts, Culture, Humanities | NY | $7,100,320Mid-sized | 81.61 |
| DemosEIN 13-4105066 | Research and Public Policy | NY | $11,762,460Mid-sized | 87.62 |
| Denver Center for the Performing ArtsEIN 84-0407760 | Arts, Culture, Humanities | CO | $52,094,113Large | 83.04 |
| Denver Film SocietyEIN 84-0771070 | Arts, Culture, Humanities | CO | $4,826,421Mid-sized | 88.24 |
| Denver Inner City ParishEIN 84-0525768 | Human Services | CO | $2,181,377Small | 88.50 |
| Denver Kids, Inc.EIN 84-1244211 | Education | CO | $2,435,764Small | 82.44 |
| Denver Rescue MissionEIN 84-6038762 | Human Services | CO | $32,935,233Large | 89.43 |
| Denver Scholarship FoundationEIN 20-5143175 | Education | CO | $9,338,023Mid-sized | 87.89 |
| Denver Street SchoolEIN 84-1216351 | Education | CO | $1,185,964Small | 88.99 |
| Denver Zoological FoundationEIN 84-0502539 | Animals | CO | $42,618,070Large | 88.57 |
| Depression and Bipolar Support Alliance, National OfficeEIN 36-3379124 | Health | IL | $2,387,816Small | 84.40 |
| Dermatology FoundationEIN 04-6115524 | Health | IL | $5,453,832Mid-sized | 81.36 |
| Des Moines Community PlayhouseEIN 42-0710259 | Arts, Culture, Humanities | IA | $2,660,897Small | 88.27 |
| Descanso Gardens Guild, Inc.EIN 95-2511202 | Environment | CA | $8,740,038Mid-sized | 89.78 |
| Desert Botanical GardenEIN 86-0136925 | Environment | AZ | $15,606,893Large | 83.88 |
| Detroit Police Athletic LeagueEIN 38-3314318 | Human Services | MI | $2,897,572Small | 81.98 |
| Dégagé MinistriesEIN 38-1912094 | Human Services | MI | $1,780,580Small | 80.83 |
| Dia Art FoundationEIN 23-7397946 | Arts, Culture, Humanities | NY | $16,546,314Large | 89.01 |
| Diabetes Action Research and Education FoundationEIN 52-1714027 | Health | MD | $2,249,926Small | 89.44 |
| Diabetes Foundation of MississippiEIN 23-7262987 | Health | MS | $804,695Small | 87.92 |
| Diabetes Research Institute FoundationEIN 59-1361955 | Health | FL | $9,613,760Mid-sized | 83.69 |
| Diabetes Youth FamiliesEIN 94-6003673 | Health | CA | $2,422,432Small | 88.04 |
| Dining for WomenEIN 20-0031928 | International | SC | $1,423,715Small | 88.01 |
| Discovery Center of SpringfieldEIN 43-1568214 | Arts, Culture, Humanities | MO | $1,154,192Small | 85.38 |
| DISCOVERY Children's MuseumEIN 94-2943891 | Arts, Culture, Humanities | NV | $5,726,927Mid-sized | 88.33 |
| Discovery InstituteEIN 91-1521697 | Research and Public Policy | WA | $5,325,118Mid-sized | 82.97 |
| Discovery MuseumEIN 04-2741645 | Arts, Culture, Humanities | MA | $1,841,437Small | 87.63 |
| District of Columbia College Access ProgramEIN 52-2132835 | Education | DC | $7,157,083Mid-sized | 86.80 |
| DKT InternationalEIN 58-1593137 | International | DC | $199,519,332Large | 88.81 |
| Doernbecher Children's Hospital FoundationEIN 93-0579589 | Health | OR | $12,481,925Mid-sized | 83.50 |
| Dogwood AllianceEIN 56-2139120 | Environment | NC | $1,552,587Small | 88.31 |
| Doheny Eye InstituteEIN 95-2916590 | Health | CA | $23,595,251Large | 82.85 |