| Central New York Community FoundationEIN 15-0626910 | Community Development | NY | $22,768,461Large | 97.89 |
| Central Oklahoma Habitat for HumanityEIN 73-1305668 | Community Development | OK | $10,160,701Mid-sized | 91.18 |
| Central Park ConservancyEIN 13-3022855 | Environment | NY | $72,425,618Large | 94.20 |
| Central Pennsylvania Food BankEIN 23-2202250 | Human Services | PA | $83,599,202Large | 98.23 |
| Central ScholarshipEIN 52-6012589 | Education | MD | $1,899,217Small | 96.74 |
| Central Texas Food BankEIN 74-2217350 | Human Services | TX | $88,983,352Large | 96.46 |
| Centre County United WayEIN 25-1215290 | Community Development | PA | $1,792,114Small | 91.96 |
| Centre Pompidou FoundationEIN 13-2941675 | Arts, Culture, Humanities | CA | $7,552,193Mid-sized | 92.22 |
| CentroEIN 41-1290349 | Human Services | MN | $1,493,898Small | 90.38 |
| Centro Legal De La RazaEIN 23-7181456 | Human and Civil Rights | CA | $5,659,231Mid-sized | 92.22 |
| Centurion MinistriesEIN 22-2563979 | Human and Civil Rights | NJ | $1,587,880Small | 92.25 |
| CeresEIN 22-3053747 | Environment | MA | $14,937,631Large | 96.52 |
| CERGE-EI FoundationEIN 25-1725738 | International | NJ | $3,260,105Small | 92.14 |
| Challenge AspenEIN 84-1315910 | Human Services | CO | $3,320,748Small | 100.00 |
| Chamber Music AmericaEIN 13-2934575 | Arts, Culture, Humanities | NY | $2,826,648Small | 91.12 |
| Chamber Music NorthwestEIN 23-7355562 | Arts, Culture, Humanities | OR | $1,637,657Small | 95.38 |
| Chamber Music Society of Lincoln CenterEIN 13-2628036 | Arts, Culture, Humanities | NY | $8,916,142Mid-sized | 91.66 |
| Changed LivesEIN 62-6081698 | Religion | TN | $1,145,541Small | 94.37 |
| Channel Islands YMCAEIN 95-1643379 | Human Services | CA | $18,458,636Large | 90.64 |
| Channel One Regional Food BankEIN 41-1379713 | Human Services | MN | $15,937,633Large | 92.05 |
| Chapman PartnershipEIN 65-0425069 | Human Services | FL | $16,277,068Large | 95.11 |
| Charity CarsEIN 59-3362703 | Human Services | FL | $7,458,283Mid-sized | 94.74 |
| Charity NewsiesEIN 31-6401150 | Human Services | OH | $1,919,088Small | 94.28 |
| Charity VisionEIN 77-0222786 | International | UT | $11,957,329Mid-sized | 96.66 |
| charity: waterEIN 22-3936753 | International | NY | $35,902,241Large | 91.16 |
| Charleston Animal SocietyEIN 57-6021863 | Animals | SC | $7,048,049Mid-sized | 94.16 |
| Charlotte BalletEIN 58-1314711 | Arts, Culture, Humanities | NC | $7,537,739Mid-sized | 93.80 |
| Charlotte Family HousingEIN 58-1599120 | Human Services | NC | $3,197,515Small | 93.41 |
| Chattahoochee RiverkeeperEIN 58-2095413 | Environment | GA | $2,483,987Small | 95.05 |
| Chattanooga Area Food BankEIN 62-0867645 | Human Services | TN | $28,411,914Large | 93.49 |
| Cheekwood Botanical Garden & Museum of ArtEIN 62-0627921 | Arts, Culture, Humanities | TN | $10,709,480Mid-sized | 96.66 |
| Cheetah Conservation FundEIN 31-1726923 | Animals | VA | $2,458,012Small | 91.55 |
| Chesapeake Bay Maritime MuseumEIN 23-7051889 | Arts, Culture, Humanities | MD | $4,451,861Mid-sized | 94.91 |
| Chesapeake Bay TrustEIN 52-1454182 | Environment | MD | $12,114,935Mid-sized | 97.23 |
| Chesapeake Climate Action NetworkEIN 11-3644283 | Environment | MD | $1,350,959Small | 91.29 |
| Chesapeake ConservancyEIN 26-2271377 | Environment | MD | $4,045,632Mid-sized | 97.13 |
| Cheyenne Mountain ZooEIN 84-0407039 | Animals | CO | $13,534,283Large | 92.94 |
| Chicago CaresEIN 36-3777709 | Community Development | IL | $3,287,575Small | 90.59 |
| Chicago Coalition for the HomelessEIN 36-3292607 | Human Services | IL | $2,898,914Small | 100.00 |
| Chicago LightsEIN 36-3786331 | Human Services | IL | $2,284,416Small | 90.66 |
| Chicago Public Library FoundationEIN 36-3480353 | Arts, Culture, Humanities | IL | $7,357,415Mid-sized | 92.92 |
| Chicago Scholars FoundationEIN 36-4117530 | Education | IL | $4,037,945Mid-sized | 90.73 |
| Chicago Shakespeare TheaterEIN 36-3467607 | Arts, Culture, Humanities | IL | $16,536,820Large | 90.52 |
| Chicago Youth ProgramsEIN 36-3635676 | Human Services | IL | $1,256,471Small | 95.05 |
| Child AdvocatesEIN 76-0111345 | Human Services | TX | $5,333,168Mid-sized | 91.93 |
| Child Advocates of Silicon ValleyEIN 77-0250773 | Human Services | CA | $2,297,246Small | 92.18 |
| Child AidEIN 33-0317937 | International | OR | $1,187,147Small | 91.16 |
| Child Crisis ArizonaEIN 86-0324144 | Human Services | AZ | $13,582,767Large | 97.39 |
| Child FoundationEIN 93-1148608 | International | OR | $3,995,592Mid-sized | 92.92 |
| Child Legacy InternationalEIN 74-2630213 | International | TX | $2,390,948Small | 95.01 |
| Child Mind InstituteEIN 80-0478843 | Health | NY | $14,159,225Large | 91.25 |
| ChildhavenEIN 91-0402430 | Human Services | WA | $10,610,919Mid-sized | 92.67 |
| Childhood Apraxia of Speech Association of North America (Apraxia Kids)EIN 25-1858159 | Health | PA | $1,654,975Small | 91.03 |
| Children IncorporatedEIN 54-0761510 | International | VA | $3,816,918Mid-sized | 92.51 |
| Children NowEIN 94-3059243 | Education | CA | $7,605,949Mid-sized | 92.02 |
| Children of Armenia FundEIN 11-3579187 | International | NY | $4,802,238Mid-sized | 92.35 |
| Children of Fallen Patriots FoundationEIN 47-0902295 | Education | VA | $5,861,743Mid-sized | 95.38 |
| Children of the NationsEIN 91-1702551 | International | WA | $8,130,373Mid-sized | 91.16 |
| Children of the NightEIN 95-3130408 | Human Services | CA | $2,637,941Small | 91.25 |
| Children's Action AllianceEIN 86-0594785 | Human Services | AZ | $2,103,586Small | 92.92 |