| Catholic Charities of Southern MinnesotaEIN 41-0721636 | Human Services | MN | $2,840,617Small | 93.42 |
| Catholic Charities of SpokaneEIN 91-0569880 | Human Services | WA | $16,225,818Large | 90.52 |
| Catholic Charities of St. Paul and MinneapolisEIN 41-1302487 | Human Services | MN | $50,683,237Large | 92.01 |
| Catholic Charities of the Archdiocese of Galveston-HoustonEIN 74-1109733 | Human Services | TX | $38,475,867Large | 93.20 |
| Catholic Charities of the Archdiocese of MilwaukeeEIN 39-0806321 | Human Services | WI | $6,103,750Mid-sized | 90.64 |
| Catholic Charities of the Archdiocese of Oklahoma CityEIN 73-0636561 | Human Services | OK | $8,014,721Mid-sized | 90.76 |
| Catholic Charities of the Diocese of FresnoEIN 94-1678938 | Human Services | CA | $5,994,629Mid-sized | 91.18 |
| Catholic Charities of the Diocese of Santa RosaEIN 94-2479393 | Human Services | CA | $13,533,849Large | 90.17 |
| Catholic Charities, Archdiocese of DenverEIN 84-0686679 | Human Services | CO | $25,590,589Large | 95.04 |
| Catholic Charities, Archdiocese of St. LouisEIN 43-0653270 | Human Services | MO | $7,104,722Mid-sized | 95.47 |
| Catholic Charities, Diocese of Venice, Inc.EIN 59-2473176 | Human Services | FL | $7,936,897Mid-sized | 90.71 |
| Catholic Community Services of Lane CountyEIN 93-0409105 | Human Services | OR | $4,582,187Mid-sized | 92.56 |
| Catholic Legal Immigration Network. Inc. (CLINIC)EIN 52-1584951 | Human and Civil Rights | MD | $6,944,953Mid-sized | 97.17 |
| Catholic Medical Mission BoardEIN 13-5602319 | International | NY | $581,681,284Large | 97.87 |
| Catholic Near East Welfare Association (CNEWA)EIN 13-1623929 | Religion | NY | $25,303,965Large | 95.54 |
| Catholic Schools FoundationEIN 22-2485502 | Education | MA | $11,109,378Mid-sized | 96.08 |
| Catholic Social Services of AnchorageEIN 92-0037322 | Human Services | AK | $10,584,775Mid-sized | 93.25 |
| Catholic Social Services of ColumbusEIN 31-4379437 | Human Services | OH | $4,873,241Mid-sized | 96.10 |
| Catholics for ChoiceEIN 52-1154418 | Human and Civil Rights | DC | $3,487,440Small | 93.10 |
| Catskill Animal SanctuaryEIN 14-1827972 | Animals | NY | $2,104,076Small | 96.35 |
| CDC FoundationEIN 58-2106707 | Health | GA | $91,221,521Large | 98.23 |
| Cedar Valley Habitat for HumanityEIN 42-1320296 | Community Development | IA | $2,697,820Small | 90.08 |
| CEDARSEIN 47-6024881 | Human Services | NE | $12,918,567Mid-sized | 95.72 |
| Celebrity Series of BostonEIN 22-2958508 | Arts, Culture, Humanities | MA | $7,898,914Mid-sized | 91.75 |
| Cenikor FoundationEIN 76-0031861 | Health | TX | $20,080,690Large | 93.59 |
| Center for a New American SecurityEIN 20-8084828 | Research and Public Policy | DC | $9,751,151Mid-sized | 96.54 |
| Center for Action and ContemplationEIN 85-0354965 | Religion | NM | $5,261,149Mid-sized | 91.09 |
| Center for American ProgressEIN 30-0126510 | Research and Public Policy | DC | $46,765,901Large | 91.15 |
| Center for Asian American MediaEIN 94-2801493 | Arts, Culture, Humanities | CA | $2,713,551Small | 90.39 |
| Center for Biological Diversity EIN 27-3943866 | Environment | AZ | $17,996,339Large | 97.87 |
| Center for Child ProtectionEIN 74-2562585 | Human Services | TX | $5,770,355Mid-sized | 91.45 |
| Center for Children and FamiliesEIN 73-0933253 | Human Services | OK | $2,145,359Small | 92.65 |
| Center for Coastal StudiesEIN 04-2609788 | Environment | MA | $3,586,500Mid-sized | 94.03 |
| Center for Constitutional RightsEIN 22-6082880 | Human and Civil Rights | NY | $10,523,997Mid-sized | 95.14 |
| Center for Creative EducationEIN 65-0594599 | Education | FL | $1,588,290Small | 98.23 |
| Center for Development ServicesEIN 57-0988275 | Human Services | SC | $1,406,021Small | 93.01 |
| Center for Excellence in EducationEIN 52-1256563 | Education | VA | $2,698,931Small | 94.97 |
| Center for Global DevelopmentEIN 52-2351337 | International | DC | $15,025,801Large | 92.81 |
| Center for Great ApesEIN 65-0444725 | Animals | FL | $1,635,911Small | 95.55 |
| Center for Health and Gender EquityEIN 31-1794048 | Human and Civil Rights | DC | $1,685,998Small | 92.22 |
| Center for Individual RightsEIN 52-1600481 | Human and Civil Rights | DC | $1,689,279Small | 94.58 |
| Center for Inspired TeachingEIN 52-1944180 | Education | DC | $2,133,311Small | 90.58 |
| Center for International Environmental LawEIN 52-1633220 | Environment | DC | $2,606,242Small | 96.20 |
| Center for Investigative ReportingEIN 94-2434026 | Arts, Culture, Humanities | CA | $13,182,677Mid-sized | 90.80 |
| Center for People in NeedEIN 06-1669552 | Human Services | NE | $8,432,172Mid-sized | 90.64 |
| Center for Puppetry ArtsEIN 58-1275610 | Arts, Culture, Humanities | GA | $4,233,410Mid-sized | 90.42 |
| Center for Reproductive RightsEIN 13-3669731 | Human and Civil Rights | NY | $24,884,918Large | 93.94 |
| Center for Responsive PoliticsEIN 52-1275227 | Human and Civil Rights | DC | $2,117,097Small | 97.10 |
| Center for Safety and ChangeEIN 13-2989233 | Human Services | NY | $3,513,740Mid-sized | 90.09 |
| Center for Security PolicyEIN 52-1601976 | International | DC | $4,972,423Mid-sized | 91.36 |
| Center for Women in TransitionEIN 38-2181204 | Human Services | MI | $2,733,719Small | 90.72 |
| Center on Budget and Policy PrioritiesEIN 52-1234565 | Research and Public Policy | DC | $28,721,352Large | 90.53 |
| Center on HalstedEIN 51-0178807 | Human and Civil Rights | IL | $6,293,773Mid-sized | 97.46 |
| Center on Policy InitiativesEIN 33-0824881 | Research and Public Policy | CA | $2,041,680Small | 91.84 |
| Central California Food BankEIN 77-0320851 | Human Services | CA | $65,008,490Large | 94.67 |
| Central Florida Zoo & Botanical GardensEIN 59-1357197 | Animals | FL | $5,702,682Mid-sized | 92.50 |
| Central Illinois FoodbankEIN 37-1106465 | Human Services | IL | $18,256,991Large | 92.92 |
| Central Indiana Community FoundationEIN 35-1793680 | Community Development | IN | $27,466,633Large | 91.42 |
| Central Institute for the DeafEIN 43-0662456 | Education | MO | $7,510,069Mid-sized | 93.44 |
| Central Iowa Shelter & ServicesEIN 42-1394212 | Human Services | IA | $2,529,003Small | 90.09 |