| Corporation for Supportive HousingEIN 13-3600232 | Community Development | NY | $38,140,011Large | 94.67 |
| Coulee Region Humane SocietyEIN 23-7366713 | Animals | WI | $1,192,417Small | 91.24 |
| Council for a Strong AmericaEIN 13-3840271 | Research and Public Policy | DC | $11,660,559Mid-sized | 95.16 |
| Court Appointed Special Advocates of Collin CountyEIN 75-2391961 | Human Services | TX | $1,201,787Small | 91.33 |
| Covenant House AlaskaEIN 13-3419755 | Human Services | AK | $7,874,566Mid-sized | 93.90 |
| Covenant House CaliforniaEIN 13-3391210 | Human Services | CA | $10,013,415Mid-sized | 95.24 |
| Covenant House FloridaEIN 59-2323607 | Human Services | FL | $8,311,668Mid-sized | 91.57 |
| Covenant House MichiganEIN 38-3351777 | Human Services | MI | $4,689,658Mid-sized | 96.08 |
| Covenant House New JerseyEIN 13-3537710 | Human Services | NJ | $10,736,994Mid-sized | 91.77 |
| Covenant House New OrleansEIN 58-1669937 | Human Services | LA | $5,601,620Mid-sized | 97.82 |
| Covenant House TexasEIN 76-0050882 | Human Services | TX | $5,541,296Mid-sized | 90.58 |
| Covenant House WashingtonEIN 13-3537709 | Human Services | DC | $5,553,135Mid-sized | 90.93 |
| Cradles to CrayonsEIN 04-3584367 | Human Services | MA | $15,682,610Large | 96.46 |
| Crayons to ClassroomsEIN 26-1594574 | Education | OH | $3,471,859Small | 97.17 |
| Crayons to ComputersEIN 31-1507076 | Education | OH | $10,934,616Mid-sized | 92.38 |
| CREATE FoundationEIN 23-7248582 | Community Development | MS | $8,181,939Mid-sized | 90.58 |
| Creative Capital FoundationEIN 31-1605982 | Arts, Culture, Humanities | NY | $5,792,226Mid-sized | 92.38 |
| Creede Repertory TheatreEIN 84-0660026 | Arts, Culture, Humanities | CO | $1,623,226Small | 91.03 |
| Crisis Aid InternationalEIN 30-0060905 | International | MO | $2,225,357Small | 97.05 |
| CRISTA MinistriesEIN 91-6012289 | Religion | WA | $114,902,453Large | 92.22 |
| Cross Roads HouseEIN 22-2549963 | Human Services | NH | $1,740,795Small | 90.76 |
| Crossnore SchoolEIN 56-0567980 | Human Services | NC | $15,549,420Large | 94.62 |
| Crossroads Prison MinistriesEIN 38-2540316 | Religion | MI | $1,852,405Small | 91.11 |
| Crossroads Urban CenterEIN 87-0295751 | Human Services | UT | $1,720,655Small | 94.78 |
| Crosstown Learning CenterEIN 73-0782748 | Human Services | OK | $2,339,373Small | 92.22 |
| Cure Alzheimer's FundEIN 52-2396428 | Health | MA | $18,999,554Large | 98.23 |
| CURE Childhood CancerEIN 58-1244138 | Health | GA | $6,232,633Mid-sized | 90.58 |
| CURE InternationalEIN 58-2248383 | International | MI | $62,536,689Large | 94.69 |
| Cystic Fibrosis Research, Inc.EIN 51-0169988 | Health | CA | $1,053,679Small | 100.00 |
| Cystinosis Research FoundationEIN 32-0067668 | Health | CA | $3,037,548Small | 90.72 |
| D.C. Bar Pro Bono CenterEIN 52-1574217 | Human and Civil Rights | DC | $2,824,873Small | 93.74 |
| D.C. Central KitchenEIN 52-1584936 | Human Services | DC | $16,677,394Large | 92.92 |
| Dallas Area Habitat for HumanityEIN 75-2097161 | Community Development | TX | $20,413,100Large | 91.70 |
| Dallas Life FoundationEIN 75-2336522 | Human Services | TX | $4,054,566Mid-sized | 94.85 |
| Damon Runyon Cancer Research FoundationEIN 13-1933825 | Health | NY | $19,596,662Large | 94.78 |
| Dan Marino FoundationEIN 65-0320556 | Health | FL | $3,486,858Small | 93.39 |
| Dana-Farber Cancer InstituteEIN 04-2263040 | Health | MA | $1,528,239,259Large | 92.74 |
| Daniel Murphy Scholarship FundEIN 36-3675466 | Education | IL | $3,844,516Mid-sized | 90.96 |
| Danita's ChildrenEIN 59-3735653 | International | TN | $2,153,385Small | 90.35 |
| Dare to Care Food BankEIN 23-7345952 | Human Services | KY | $43,226,997Large | 97.26 |
| DAV (Disabled American Veterans) Charitable Service TrustEIN 52-1521276 | Human Services | KY | $7,103,580Mid-sized | 92.01 |
| Dave Thomas Foundation for AdoptionEIN 31-1356151 | Human Services | OH | $24,102,108Large | 96.29 |
| David Lynch Foundation for Consciousness-Based EducationEIN 83-0436453 | Education | NY | $12,365,779Mid-sized | 92.14 |
| Days End Farm Horse RescueEIN 52-1759077 | Animals | MD | $1,570,461Small | 90.22 |
| Daystar Life CenterEIN 65-0523539 | Human Services | FL | $1,115,568Small | 91.36 |
| Dayton HistoryEIN 31-6037490 | Arts, Culture, Humanities | OH | $5,703,691Mid-sized | 92.22 |
| Deborah Hospital FoundationEIN 22-2049500 | Health | NJ | $11,597,550Mid-sized | 93.83 |
| Deborah's PlaceEIN 36-3382973 | Human Services | IL | $3,473,862Small | 94.48 |
| Delancey Street FoundationEIN 23-7102690 | Human Services | CA | $102,283,206Large | 91.45 |
| Delaware Nature SocietyEIN 51-6018321 | Environment | DE | $4,326,285Mid-sized | 91.54 |
| Delivering GoodEIN 13-3300271 | Human Services | NY | $217,120,707Large | 94.69 |
| Democracy North CarolinaEIN 56-2271150 | Human and Civil Rights | NC | $2,142,045Small | 92.78 |
| Denver Art MuseumEIN 84-6038240 | Arts, Culture, Humanities | CO | $41,996,799Large | 91.19 |
| Denver Botanic GardensEIN 84-0440359 | Environment | CO | $21,365,255Large | 90.84 |
| Denver Public Library Friends FoundationEIN 84-6036979 | Arts, Culture, Humanities | CO | $2,403,593Small | 90.64 |
| Des Moines Art CenterEIN 42-0680419 | Arts, Culture, Humanities | IA | $8,717,426Mid-sized | 91.88 |
| Desert AIDS ProjectEIN 33-0068583 | Health | CA | $32,043,691Large | 95.02 |
| Desire Street MinistriesEIN 72-1218825 | Religion | GA | $2,453,814Small | 94.46 |
| Detroit Historical SocietyEIN 38-1381144 | Arts, Culture, Humanities | MI | $5,818,479Mid-sized | 90.52 |
| Detroit Rescue Mission MinistriesEIN 38-1459371 | Human Services | MI | $20,146,632Large | 91.70 |