| Detroit Symphony OrchestraEIN 38-1385132 | Arts, Culture, Humanities | MI | $36,345,989Large | 92.06 |
| Detroit Zoological SocietyEIN 38-6027356 | Animals | MI | $40,691,390Large | 92.44 |
| Development Associates InternationalEIN 23-2838716 | Religion | CO | $5,989,502Mid-sized | 91.91 |
| Developments in LiteracyEIN 33-0843213 | Education | CA | $2,641,317Small | 91.12 |
| Dian Fossey Gorilla Fund InternationalEIN 52-1118866 | Animals | GA | $3,297,143Small | 92.38 |
| Direct ReliefEIN 95-1831116 | International | CA | $1,008,907,873Large | 100.00 |
| DiscipleMakersEIN 25-1411175 | Religion | PA | $4,832,863Mid-sized | 94.16 |
| Discovery Green ConservancyEIN 20-1951465 | Environment | TX | $7,362,363Mid-sized | 94.07 |
| Discovery PlaceEIN 56-0529944 | Arts, Culture, Humanities | NC | $15,241,959Large | 91.91 |
| Discovery WorldEIN 39-1691578 | Arts, Culture, Humanities | WI | $9,457,339Mid-sized | 90.71 |
| Do SomethingEIN 13-3720473 | Human Services | NY | $10,095,721Mid-sized | 93.37 |
| Doctors CareEIN 84-1150815 | Health | CO | $2,543,801Small | 95.05 |
| Doctors Without Borders, USAEIN 13-3433452 | International | NY | $420,595,919Large | 94.74 |
| Dogs for Better LivesEIN 93-0681311 | Animals | OR | $3,363,233Small | 95.93 |
| Dollar Energy FundEIN 25-1442933 | Human Services | PA | $15,557,633Large | 91.16 |
| Domestic Abuse Intervention ServicesEIN 39-1268238 | Human Services | WI | $3,256,031Small | 93.70 |
| Domestic Abuse Project of Delaware CountyEIN 23-2053144 | Human Services | PA | $1,766,699Small | 90.06 |
| Domestic Violence Intervention Services, Inc. (DVIS)EIN 73-1028332 | Human Services | OK | $6,638,122Mid-sized | 93.99 |
| DonorsChoose.orgEIN 13-4129457 | Education | NY | $102,666,357Large | 96.66 |
| Doorways for Women and FamiliesEIN 54-1087829 | Human Services | VA | $4,770,512Mid-sized | 93.46 |
| DOROTEIN 13-3264005 | Human Services | NY | $7,626,167Mid-sized | 92.96 |
| Downtown Community Television CenterEIN 13-2742777 | Arts, Culture, Humanities | NY | $3,066,888Small | 91.45 |
| Downtown Rescue MissionEIN 63-0735295 | Human Services | AL | $8,473,047Mid-sized | 90.69 |
| Dr. Susan Love Research FoundationEIN 77-0009065 | Health | CA | $2,750,486Small | 93.08 |
| DREAMEIN 13-4025290 | Human Services | NY | $15,172,457Large | 91.42 |
| Dream FactoryEIN 61-1220742 | Health | KY | $2,252,925Small | 92.38 |
| Dream FoundationEIN 77-0405779 | Health | CA | $4,761,331Mid-sized | 94.27 |
| Dreams Come TrueEIN 59-2967803 | Health | FL | $2,459,405Small | 92.22 |
| Dress for Success HoustonEIN 76-0579697 | Human Services | TX | $2,618,328Small | 94.63 |
| Dress for Success WorldwideEIN 13-4040377 | Human Services | NY | $22,405,064Large | 91.40 |
| Dubuque County Historical SocietyEIN 42-6072050 | Arts, Culture, Humanities | IA | $7,001,981Mid-sized | 90.87 |
| Dumb Friends LeagueEIN 84-0405254 | Animals | CO | $18,015,992Large | 90.47 |
| DuPage PADSEIN 36-3675494 | Human Services | IL | $4,142,129Mid-sized | 90.86 |
| Durham Rescue MissionEIN 58-1482590 | Human Services | NC | $11,976,198Mid-sized | 100.00 |
| Dystonia Medical Research FoundationEIN 95-3378526 | Health | IL | $2,608,986Small | 95.85 |
| Dystrophic Epidermolysis Bullosa Research Association of America (debra of America)EIN 11-2519726 | Health | NY | $1,416,573Small | 93.82 |
| dZi FoundationEIN 84-1595852 | International | CO | $1,351,526Small | 94.74 |
| Eagle MountEIN 84-1383214 | Health | MT | $1,623,071Small | 91.51 |
| Eagle RanchEIN 58-1497408 | Human Services | GA | $4,667,626Mid-sized | 93.88 |
| EARN, Inc. EIN 91-2172676 | Community Development | CA | $3,710,835Mid-sized | 91.23 |
| Earth Day NetworkEIN 13-3798288 | Environment | DC | $2,970,282Small | 91.94 |
| EarthjusticeEIN 94-1730465 | Environment | CA | $51,564,754Large | 94.85 |
| EarthRights InternationalEIN 04-3265555 | International | DC | $3,343,499Small | 99.01 |
| EARTHWORKSEIN 52-1557765 | Environment | DC | $3,301,953Small | 94.74 |
| East Bay Alliance for A Sustainable EconomyEIN 94-3314108 | Human Services | CA | $1,290,909Small | 91.25 |
| East Cooper Community OutreachEIN 57-0939280 | Human Services | SC | $1,871,995Small | 97.17 |
| East Harlem Tutorial ProgramEIN 23-7439789 | Education | NY | $9,065,798Mid-sized | 92.30 |
| East Side HouseEIN 13-1623989 | Human Services | NY | $22,000,963Large | 98.23 |
| East Tennessee PBSEIN 62-1173293 | Arts, Culture, Humanities | TN | $3,188,133Small | 90.71 |
| East Texas Food BankEIN 75-2222686 | Human Services | TX | $32,138,551Large | 95.28 |
| East-West Ministries InternationalEIN 75-2486132 | Religion | TX | $17,806,811Large | 93.10 |
| Easter Seals Capper FoundationEIN 48-0543745 | Human Services | KS | $13,693,269Large | 92.92 |
| Eastern Illinois FoodbankEIN 37-1130252 | Human Services | IL | $19,826,056Large | 95.05 |
| Eastside College Preparatory SchoolEIN 94-3187806 | Education | CA | $8,497,745Mid-sized | 93.29 |
| EastWest InstituteEIN 13-3091844 | International | NY | $8,643,444Mid-sized | 91.02 |
| ECAD, Educated Canines Assisting with DisabilitiesEIN 06-1436718 | Animals | CT | $895,834Small | 92.92 |
| ECHOEIN 23-7275283 | International | FL | $4,125,712Mid-sized | 95.27 |
| ECHO (Everyone Cooperating to Help Others)EIN 39-1222279 | Human Services | WI | $2,388,786Small | 92.59 |
| ECHO Lake Aquarium and Science CenterEIN 03-0347288 | Arts, Culture, Humanities | VT | $3,464,446Small | 91.45 |
| EcoHealth AllianceEIN 31-1726494 | Animals | NY | $13,652,783Large | 92.92 |