| San Antonio Humane SocietyEIN 74-6024105 | Animals | TX | $4,354,685Mid-sized | 95.34 |
| San Diego Center for the BlindEIN 95-3076944 | Health | CA | $1,712,478Small | 94.05 |
| San Diego Children's Discovery MuseumEIN 33-0912735 | Arts, Culture, Humanities | CA | $1,516,896Small | 91.02 |
| San Diego Habitat for HumanityEIN 33-0259190 | Community Development | CA | $10,957,226Mid-sized | 92.92 |
| San Diego Humane Society EIN 95-1661688 | Animals | CA | $25,491,250Large | 92.49 |
| San Diego Museum of ArtEIN 95-1696715 | Arts, Culture, Humanities | CA | $12,653,010Mid-sized | 90.46 |
| San Diego Museum of ManEIN 95-1709290 | Arts, Culture, Humanities | CA | $4,304,545Mid-sized | 93.36 |
| San Diego Symphony OrchestraEIN 95-2040874 | Arts, Culture, Humanities | CA | $26,040,490Large | 93.01 |
| San Diego Zoo GlobalEIN 95-1648219 | Animals | CA | $263,690,859Large | 92.36 |
| San Francisco AIDS FoundationEIN 94-2927405 | Health | CA | $31,653,409Large | 92.19 |
| San Francisco Botanical Garden SocietyEIN 94-6050168 | Environment | CA | $4,261,791Mid-sized | 92.52 |
| San Francisco CASAEIN 94-3039028 | Human Services | CA | $1,314,905Small | 92.51 |
| San Francisco Education FundEIN 94-1592822 | Education | CA | $2,439,113Small | 97.17 |
| San Francisco Parks AllianceEIN 23-7131784 | Environment | CA | $15,142,255Large | 92.48 |
| San Francisco SPCAEIN 94-0836580 | Animals | CA | $37,358,567Large | 95.47 |
| San Gabriel Valley Habitat for HumanityEIN 95-4244947 | Community Development | CA | $4,289,122Mid-sized | 100.00 |
| San Joaquin River Parkway and Conservation TrustEIN 77-0196692 | Environment | CA | $1,749,897Small | 90.56 |
| Sanctuary for FamiliesEIN 13-3193119 | Human Services | NY | $21,026,926Large | 92.24 |
| Sanibel-Captiva Conservation FoundationEIN 59-1205087 | Environment | FL | $3,095,476Small | 90.45 |
| Sankara Eye Foundation, USAEIN 77-6141976 | Health | CA | $7,330,498Mid-sized | 100.00 |
| Santa Barbara Botanic GardenEIN 95-1644628 | Environment | CA | $3,907,707Mid-sized | 90.80 |
| Santa Barbara FoundationEIN 95-1866094 | Community Development | CA | $32,703,267Large | 95.50 |
| Santa Barbara Museum of ArtEIN 95-1664122 | Arts, Culture, Humanities | CA | $8,480,089Mid-sized | 92.24 |
| Santa Barbara Neighborhood ClinicsEIN 77-0496382 | Health | CA | $14,396,726Large | 91.45 |
| Santa Barbara ZooEIN 95-2268554 | Animals | CA | $11,444,973Mid-sized | 93.81 |
| Santa Cruz Museum of Art and History at the McPherson CenterEIN 94-2718861 | Arts, Culture, Humanities | CA | $1,864,470Small | 92.02 |
| Santa Fe Animal Shelter & Humane SocietyEIN 85-6000484 | Animals | NM | $7,928,140Mid-sized | 90.45 |
| Sarah's CircleEIN 36-3043662 | Human Services | IL | $2,023,629Small | 92.21 |
| Sarasota OrchestraEIN 59-2603081 | Arts, Culture, Humanities | FL | $9,770,009Mid-sized | 90.31 |
| Sarcoma Foundation of AmericaEIN 52-2275294 | Health | MD | $1,903,735Small | 94.74 |
| Sargent Shriver National Center on Poverty LawEIN 36-3151279 | Human and Civil Rights | IL | $5,797,979Mid-sized | 92.18 |
| Savannah Jewish FederationEIN 58-0566231 | Community Development | GA | $2,108,440Small | 94.04 |
| Save a Child's Heart FoundationEIN 52-1783323 | International | MD | $2,474,430Small | 96.16 |
| Save the Manatee ClubEIN 59-3131709 | Animals | FL | $1,168,356Small | 90.23 |
| SAVE, A Friend to Homeless AnimalsEIN 22-6082741 | Animals | NJ | $1,313,195Small | 90.29 |
| Save-A-Pet Adoption CenterEIN 23-7304570 | Animals | IL | $1,746,870Small | 91.33 |
| SBH Community Service NetworkEIN 23-7406410 | Human Services | NY | $9,752,470Mid-sized | 96.54 |
| SBPEIN 26-2189665 | Human Services | LA | $15,115,618Large | 95.12 |
| Schlitz Audubon Nature CenterEIN 39-1231819 | Environment | WI | $2,897,570Small | 90.69 |
| Scholarship Foundation of Santa BarbaraEIN 23-7087774 | Education | CA | $10,071,712Mid-sized | 91.88 |
| School on WheelsEIN 95-4422640 | Education | CA | $2,114,477Small | 95.47 |
| Science Friday InitiativeEIN 13-4252173 | Arts, Culture, Humanities | NY | $2,963,802Small | 92.22 |
| Science Museum OklahomaEIN 73-0682415 | Arts, Culture, Humanities | OK | $10,733,779Mid-sized | 96.87 |
| Scleroderma FoundationEIN 52-1375827 | Health | MA | $5,211,320Mid-sized | 96.52 |
| Scleroderma Research FoundationEIN 68-0087234 | Health | CA | $2,527,636Small | 97.17 |
| Scott County Family YEIN 42-0703278 | Human Services | IA | $10,300,667Mid-sized | 93.54 |
| Sea Turtle ConservancyEIN 59-6151069 | Animals | FL | $3,339,353Small | 96.46 |
| Search and CareEIN 23-7444790 | Human Services | NY | $1,381,511Small | 94.70 |
| Seattle Arts and LecturesEIN 91-1384964 | Arts, Culture, Humanities | WA | $1,666,625Small | 90.52 |
| Seattle FoundationEIN 91-6013536 | Community Development | WA | $110,286,703Large | 94.51 |
| Seattle Parks FoundationEIN 91-1998597 | Environment | WA | $2,525,864Small | 97.13 |
| Second Harvest Community Food BankEIN 43-1268319 | Human Services | MO | $10,909,604Mid-sized | 93.83 |
| Second Harvest Food Bank of Central FloridaEIN 59-2142315 | Human Services | FL | $122,484,539Large | 92.92 |
| Second Harvest Food Bank of East TennesseeEIN 58-1450139 | Human Services | TN | $29,394,281Large | 90.23 |
| Second Harvest Food Bank of Greater New Orleans and AcadianaEIN 72-0956468 | Human Services | LA | $73,953,206Large | 94.69 |
| Second Harvest Food Bank of MetrolinaEIN 56-1352593 | Human Services | NC | $97,534,285Large | 90.22 |
| Second Harvest Food Bank of North Central OhioEIN 34-1446685 | Human Services | OH | $11,486,199Mid-sized | 96.94 |
| Second Harvest Food Bank of Northeast TennesseeEIN 62-1303822 | Human Services | TN | $20,333,455Large | 93.56 |
| Second Harvest Food Bank of Northwest North CarolinaEIN 58-1457912 | Human Services | NC | $60,851,278Large | 96.46 |
| Second Harvest Food Bank of Northwest PennsylvaniaEIN 25-1405798 | Human Services | PA | $18,759,837Large | 92.92 |