| Society for the Protection of New Hampshire ForestsEIN 02-0222237 | Environment | NH | $7,278,002Mid-sized | 94.94 |
| Society of St. Vincent De Paul Archdiocesan Council of St. LouisEIN 43-0652684 | Human Services | MO | $23,619,507Large | 92.02 |
| Solar Cookers InternationalEIN 68-0153141 | Environment | CA | $773,030Small | 91.37 |
| Soldiers' AngelsEIN 20-0583415 | Human Services | TX | $18,391,429Large | 94.28 |
| Soles4SoulsEIN 20-4023482 | International | TN | $83,106,075Large | 98.23 |
| Solid GroundEIN 36-3578158 | Human Services | MN | $1,371,215Small | 97.58 |
| Solid Rock InternationalEIN 34-1719319 | Religion | IN | $1,389,061Small | 96.88 |
| SOMEEIN 23-7098123 | Human Services | DC | $28,344,473Large | 93.11 |
| SoundWatersEIN 06-1263947 | Environment | CT | $2,007,465Small | 94.48 |
| South Asian Youth ActionEIN 13-3943630 | Human Services | NY | $3,370,395Small | 95.04 |
| South Dakota Community FoundationEIN 46-0398115 | Community Development | SD | $13,502,997Large | 90.26 |
| South Florida Science Center and AquariumEIN 59-0915177 | Arts, Culture, Humanities | FL | $3,583,072Mid-sized | 90.59 |
| South Plains Food BankEIN 75-1904829 | Human Services | TX | $15,594,953Large | 90.67 |
| South Shore Habitat for HumanityEIN 22-2701789 | Community Development | MA | $2,438,899Small | 94.69 |
| Southeast Missouri Food BankEIN 43-1395863 | Human Services | MO | $16,120,107Large | 97.17 |
| Southeastern Guide DogsEIN 59-2252352 | Animals | FL | $9,239,038Mid-sized | 95.32 |
| Southern Center for Human RightsEIN 62-1025326 | Human and Civil Rights | GA | $2,747,262Small | 99.34 |
| Southern Environmental Law CenterEIN 52-1436778 | Environment | VA | $26,551,471Large | 100.00 |
| Southern Minnesota Initiative FoundationEIN 36-3454285 | Community Development | MN | $4,891,201Mid-sized | 92.20 |
| Southern Oregon Humane SocietyEIN 93-0391640 | Animals | OR | $893,883Small | 95.57 |
| Southern Scholarship FoundationEIN 59-0939481 | Education | FL | $1,950,039Small | 94.17 |
| Southern Utah Wilderness AllianceEIN 94-2936961 | Environment | UT | $2,658,079Small | 93.68 |
| Southwest Autism Research & Resource CenterEIN 31-1496646 | Health | AZ | $10,419,604Mid-sized | 92.02 |
| SPCA CincinnatiEIN 31-0543284 | Animals | OH | $6,230,961Mid-sized | 96.13 |
| SPCA of Anne Arundel CountyEIN 52-0609154 | Animals | MD | $1,645,867Small | 95.00 |
| SPCA of TexasEIN 75-1216660 | Animals | TX | $18,553,754Large | 95.77 |
| SPCA of WestchesterEIN 13-1740069 | Animals | NY | $2,832,609Small | 100.00 |
| Special K RanchEIN 36-3378581 | Human Services | MT | $1,872,180Small | 90.04 |
| Special OlympicsEIN 52-0889518 | Human Services | DC | $110,965,732Large | 90.49 |
| Special Olympics FloridaEIN 23-7181560 | Human Services | FL | $13,729,105Large | 92.61 |
| Special Olympics HawaiiEIN 23-7173957 | Human Services | HI | $2,490,312Small | 92.65 |
| Special Olympics IllinoisEIN 36-2922811 | Human Services | IL | $9,727,839Mid-sized | 93.81 |
| Special Olympics IndianaEIN 35-1262574 | Human Services | IN | $4,170,414Mid-sized | 90.61 |
| Special Olympics MontanaEIN 81-0367064 | Human Services | MT | $2,626,115Small | 96.16 |
| Special Olympics New JerseyEIN 23-7448729 | Human Services | NJ | $7,620,689Mid-sized | 93.32 |
| Special Olympics North CarolinaEIN 56-1149607 | Human Services | NC | $4,726,674Mid-sized | 92.74 |
| Special Olympics of PennsylvaniaEIN 23-2078543 | Human Services | PA | $7,444,959Mid-sized | 90.34 |
| Special Olympics OklahomaEIN 23-7174120 | Human Services | OK | $1,669,667Small | 90.94 |
| Special Olympics South CarolinaEIN 57-0680248 | Human Services | SC | $2,816,864Small | 91.89 |
| Special Olympics South DakotaEIN 46-0359776 | Human Services | SD | $1,508,882Small | 92.62 |
| Special Olympics Southern CaliforniaEIN 95-4538450 | Human Services | CA | $11,029,255Mid-sized | 97.23 |
| Special Operations Warrior FoundationEIN 52-1183585 | Education | FL | $11,730,490Mid-sized | 94.47 |
| Spirit of AmericaEIN 20-1687786 | International | VA | $3,626,101Mid-sized | 96.83 |
| Splash InternationalEIN 56-2600599 | International | WA | $3,266,231Small | 94.18 |
| Spondylitis Association of AmericaEIN 95-3890767 | Health | CA | $1,301,054Small | 91.90 |
| Sponsors for Educational Opportunity (SEO)EIN 13-2578670 | Education | NY | $17,839,508Large | 99.93 |
| Spread the Word NevadaEIN 22-3829041 | Education | NV | $3,504,067Mid-sized | 98.23 |
| SquashBustersEIN 04-3330698 | Education | MA | $2,154,696Small | 91.21 |
| St. Ann's Center for Children, Youth and FamiliesEIN 53-0204626 | Human Services | MD | $4,519,774Mid-sized | 90.31 |
| St. Anne'sEIN 95-1691306 | Human Services | CA | $25,417,077Large | 93.91 |
| St. Boniface Haiti FoundationEIN 04-3067595 | International | MA | $22,333,400Large | 95.87 |
| St. Hubert's Animal Welfare CenterEIN 22-1627726 | Animals | NJ | $5,921,842Mid-sized | 98.16 |
| St. Joseph CenterEIN 95-3874381 | Human Services | CA | $15,753,740Large | 91.58 |
| St. Louis Area FoodbankEIN 43-1253102 | Human Services | MO | $81,514,749Large | 98.86 |
| St. Mary's CenterEIN 68-0172229 | Human Services | CA | $3,039,558Small | 96.66 |
| St. Mary's Food Bank AllianceEIN 23-7353532 | Human Services | AZ | $160,093,972Large | 93.07 |
| St. Matthew's HouseEIN 65-1110501 | Human Services | FL | $7,624,221Mid-sized | 92.14 |
| St. Petersburg Free ClinicEIN 23-7208280 | Health | FL | $12,323,655Mid-sized | 97.17 |
| St. Vincent de Paul of BaltimoreEIN 52-0597056 | Human Services | MD | $20,808,081Large | 94.18 |
| St. Vincent de Paul Society of Marin CountyEIN 94-1207701 | Human Services | CA | $4,107,059Mid-sized | 96.42 |