| Stand for Children Leadership CenterEIN 52-1957214 | Education | OR | $15,543,445Large | 90.22 |
| StandUp for KidsEIN 33-0414855 | Human Services | GA | $1,220,228Small | 92.02 |
| StandWithUsEIN 01-0566033 | International | CA | $12,583,673Mid-sized | 95.47 |
| Starkey Hearing FoundationEIN 36-3297852 | Human Services | MN | $21,659,389Large | 92.82 |
| Starlight Children's FoundationEIN 95-3802159 | Health | CA | $9,806,057Mid-sized | 93.94 |
| STARSEIN 62-1285699 | Human Services | TN | $3,850,505Mid-sized | 91.27 |
| State University College at Oneonta Foundation CorporationEIN 22-2403203 | Education | NY | $3,696,700Mid-sized | 92.96 |
| State VoicesEIN 20-1115618 | Human and Civil Rights | DC | $13,763,270Large | 94.07 |
| Statue of Liberty-Ellis Island FoundationEIN 13-3118415 | Arts, Culture, Humanities | NY | $18,817,780Large | 92.24 |
| STEPEIN 51-0188692 | Human Services | MN | $2,169,879Small | 93.36 |
| Step UpEIN 95-4701468 | Human Services | CA | $4,222,065Mid-sized | 95.14 |
| Step Up For StudentsEIN 59-3649371 | Education | FL | $674,603,917Large | 96.66 |
| Stephen Siller Tunnel to Towers FoundationEIN 02-0554654 | Human Services | NY | $16,641,583Large | 98.23 |
| Stewpot Community ServicesEIN 64-0655566 | Human Services | MS | $2,160,764Small | 91.15 |
| Stony Brook Millstone Watershed Association EIN 21-0649717 | Environment | NJ | $2,183,497Small | 91.01 |
| StoryCorpsEIN 13-3753011 | Arts, Culture, Humanities | NY | $10,638,243Mid-sized | 94.93 |
| Storyteller Children's CenterEIN 77-0283072 | Human Services | CA | $1,611,343Small | 91.38 |
| StrathmoreEIN 52-1233092 | Arts, Culture, Humanities | MD | $12,121,219Mid-sized | 90.00 |
| Strawbery Banke MuseumEIN 02-0260158 | Arts, Culture, Humanities | NH | $3,204,942Small | 93.92 |
| Street SchoolEIN 73-0942963 | Education | OK | $2,022,478Small | 97.66 |
| Streets MinistriesEIN 62-1763815 | Human Services | TN | $2,137,688Small | 92.33 |
| Strong City BaltimoreEIN 52-0897806 | Human Services | MD | $11,112,362Mid-sized | 90.71 |
| Stroud Water Research CenterEIN 52-2081073 | Environment | PA | $9,504,082Mid-sized | 91.98 |
| Student Leadership NetworkEIN 06-1517218 | Education | NY | $9,472,942Mid-sized | 92.02 |
| Student Sponsor PartnersEIN 13-3392965 | Education | NY | $7,283,038Mid-sized | 91.46 |
| Students Rising AboveEIN 81-0615887 | Education | CA | $4,271,682Mid-sized | 90.42 |
| Students Run LAEIN 95-4430502 | Human Services | CA | $2,637,828Small | 97.10 |
| Sulzbacher CenterEIN 59-3229898 | Human Services | FL | $14,566,080Large | 92.02 |
| Summit Academy OICEIN 41-0908458 | Education | MN | $7,997,922Mid-sized | 93.46 |
| Sunflower HouseEIN 48-0918698 | Human Services | KS | $1,483,883Small | 93.82 |
| Sunnyvale Community ServicesEIN 94-1713897 | Human Services | CA | $7,426,109Mid-sized | 95.10 |
| Sunshine Division Portland Police DeptEIN 93-0429354 | Human Services | OR | $5,667,244Mid-sized | 90.89 |
| Support Center for Child AdvocatesEIN 23-2048664 | Human and Civil Rights | PA | $3,549,961Mid-sized | 91.29 |
| Support The Enlisted Project (STEP)EIN 20-3051279 | Human Services | CA | $1,681,670Small | 94.41 |
| Surrey Services for SeniorsEIN 23-2610145 | Human Services | PA | $4,603,921Mid-sized | 91.37 |
| Sustainable Food CenterEIN 74-2441468 | Human Services | TX | $2,309,673Small | 91.45 |
| Symphony SpaceEIN 13-2941455 | Arts, Culture, Humanities | NY | $6,686,548Mid-sized | 91.83 |
| SynergosEIN 13-3392006 | International | NY | $14,088,067Large | 93.42 |
| Table to TableEIN 22-3646125 | Human Services | NJ | $26,205,578Large | 98.23 |
| Taco Bell FoundationEIN 33-0523542 | Education | CA | $9,729,593Mid-sized | 91.14 |
| Take Stock in Children Palm Beach CountyEIN 20-8077416 | Education | FL | $1,371,374Small | 91.59 |
| Taking Control of Your DiabetesEIN 33-0794608 | Health | CA | $4,188,227Mid-sized | 91.45 |
| Tamassee DAR SchoolEIN 57-6000973 | Human Services | SC | $3,358,215Small | 91.85 |
| Tampa Metropolitan Area YMCAEIN 59-1742909 | Human Services | FL | $33,632,520Large | 92.49 |
| Tanenbaum Center for Interreligious UnderstandingEIN 13-3695475 | Research and Public Policy | NY | $1,992,629Small | 90.41 |
| Tanzanian Children's FundEIN 74-3087284 | International | MA | $1,651,005Small | 94.78 |
| Tarrant Area Food BankEIN 75-1822473 | Human Services | TX | $61,702,181Large | 94.77 |
| Taxpayers for Common SenseEIN 52-1941122 | Human and Civil Rights | DC | $1,821,148Small | 92.02 |
| Taylor Family FoundationEIN 94-3262932 | Health | CA | $1,783,479Small | 91.02 |
| TB AllianceEIN 13-4128413 | Health | NY | $54,033,661Large | 95.64 |
| Teaching MattersEIN 13-3770472 | Education | NY | $6,009,669Mid-sized | 94.45 |
| Team RubiconEIN 27-1720480 | International | CA | $11,426,753Mid-sized | 91.42 |
| Teammates for Kids FoundationEIN 84-1484370 | Human Services | CO | $3,014,134Small | 94.24 |
| Teen Challenge of Southern CaliforniaEIN 95-2683852 | Health | CA | $11,965,819Mid-sized | 90.26 |
| Teen Parent ConnectionEIN 36-3387034 | Human Services | IL | $1,190,319Small | 92.23 |
| Tennyson Center for ChildrenEIN 61-1458290 | Human Services | CO | $13,684,410Large | 91.30 |
| Teton Science SchoolsEIN 83-0219163 | Environment | WY | $14,782,834Large | 90.70 |
| Texas Civil Rights ProjectEIN 74-1995879 | Human and Civil Rights | TX | $2,274,016Small | 95.12 |
| Texas Parks and Wildlife FoundationEIN 74-2602504 | Environment | TX | $6,241,257Mid-sized | 95.05 |
| Texas Public Policy FoundationEIN 74-2524057 | Research and Public Policy | TX | $8,681,038Mid-sized | 91.89 |