| Creative Capital FoundationEIN 31-1605982 | Arts, Culture, Humanities | NY | $5,792,226Mid-sized | 92.38 |
| Crisis Control MinistryEIN 23-7348168 | Human Services | NC | $4,455,399Mid-sized | 89.39 |
| CrossOver Healthcare MinistryEIN 54-1371067 | Health | VA | $5,840,704Mid-sized | 89.02 |
| Crow Canyon Archaeological CenterEIN 84-0631786 | Arts, Culture, Humanities | CO | $4,488,765Mid-sized | 86.52 |
| Crown Financial MinistriesEIN 58-1260812 | Religion | TN | $4,923,465Mid-sized | 75.33 |
| CURE Childhood CancerEIN 58-1244138 | Health | GA | $6,232,633Mid-sized | 90.58 |
| Cure SMAEIN 36-3320440 | Health | IL | $7,566,017Mid-sized | 84.58 |
| CuriOdysseyEIN 94-1262434 | Arts, Culture, Humanities | CA | $4,418,168Mid-sized | 86.57 |
| D. James Kennedy MinistriesEIN 65-0496702 | Religion | FL | $4,790,042Mid-sized | 85.12 |
| D.A.R.E. AmericaEIN 95-4242541 | Health | CA | $12,067,579Mid-sized | 70.66 |
| Dallas Life FoundationEIN 75-2336522 | Human Services | TX | $4,054,566Mid-sized | 94.85 |
| Dallas Theater CenterEIN 75-0959992 | Arts, Culture, Humanities | TX | $10,134,614Mid-sized | 81.30 |
| Dallas Zoological SocietyEIN 75-0964982 | Animals | TX | $12,677,533Mid-sized | 88.08 |
| Dance Theatre of HarlemEIN 13-2642091 | Arts, Culture, Humanities | NY | $5,536,736Mid-sized | 83.11 |
| Dane County Humane SocietyEIN 39-0806335 | Animals | WI | $3,719,068Mid-sized | 87.15 |
| Daniel Murphy Scholarship FundEIN 36-3675466 | Education | IL | $3,844,516Mid-sized | 90.96 |
| Dare 2 Share MinistriesEIN 84-0504202 | Religion | CO | $3,524,068Mid-sized | 85.23 |
| Daughters of Charity Services of San AntonioEIN 74-6106876 | Human Services | TX | $6,688,924Mid-sized | 89.78 |
| DAV (Disabled American Veterans) Charitable Service TrustEIN 52-1521276 | Human Services | KY | $7,103,580Mid-sized | 92.01 |
| David Lynch Foundation for Consciousness-Based EducationEIN 83-0436453 | Education | NY | $12,365,779Mid-sized | 92.14 |
| Dayspring InternationalEIN 51-0237239 | Religion | VA | $7,364,681Mid-sized | 72.03 |
| Dayton Art InstituteEIN 31-0537480 | Arts, Culture, Humanities | OH | $5,217,588Mid-sized | 84.58 |
| Dayton HistoryEIN 31-6037490 | Arts, Culture, Humanities | OH | $5,703,691Mid-sized | 92.22 |
| Dayton Performing Arts AllianceEIN 31-6000101 | Arts, Culture, Humanities | OH | $8,167,915Mid-sized | 83.97 |
| Dayton Society of Natural HistoryEIN 31-0585917 | Arts, Culture, Humanities | OH | $5,296,073Mid-sized | 79.89 |
| Deborah Hospital FoundationEIN 22-2049500 | Health | NJ | $11,597,550Mid-sized | 93.83 |
| DeCordova Sculpture Park and MuseumEIN 04-2067315 | Arts, Culture, Humanities | MA | $4,862,222Mid-sized | 79.43 |
| Delaware Art MuseumEIN 51-0065746 | Arts, Culture, Humanities | DE | $5,189,312Mid-sized | 87.68 |
| Delaware Nature SocietyEIN 51-6018321 | Environment | DE | $4,326,285Mid-sized | 91.54 |
| Delta Waterfowl FoundationEIN 53-0259796 | Animals | ND | $9,628,880Mid-sized | 87.69 |
| Democracy Now!EIN 01-0708733 | Arts, Culture, Humanities | NY | $7,100,320Mid-sized | 81.61 |
| DemosEIN 13-4105066 | Research and Public Policy | NY | $11,762,460Mid-sized | 87.62 |
| Denver Film SocietyEIN 84-0771070 | Arts, Culture, Humanities | CO | $4,826,421Mid-sized | 88.24 |
| Denver Scholarship FoundationEIN 20-5143175 | Education | CO | $9,338,023Mid-sized | 87.89 |
| Dermatology FoundationEIN 04-6115524 | Health | IL | $5,453,832Mid-sized | 81.36 |
| Des Moines Art CenterEIN 42-0680419 | Arts, Culture, Humanities | IA | $8,717,426Mid-sized | 91.88 |
| Descanso Gardens Guild, Inc.EIN 95-2511202 | Environment | CA | $8,740,038Mid-sized | 89.78 |
| Detroit Historical SocietyEIN 38-1381144 | Arts, Culture, Humanities | MI | $5,818,479Mid-sized | 90.52 |
| Development Associates InternationalEIN 23-2838716 | Religion | CO | $5,989,502Mid-sized | 91.91 |
| Diabetes Research Institute FoundationEIN 59-1361955 | Health | FL | $9,613,760Mid-sized | 83.69 |
| DiscipleMakersEIN 25-1411175 | Religion | PA | $4,832,863Mid-sized | 94.16 |
| DISCOVERY Children's MuseumEIN 94-2943891 | Arts, Culture, Humanities | NV | $5,726,927Mid-sized | 88.33 |
| Discovery Green ConservancyEIN 20-1951465 | Environment | TX | $7,362,363Mid-sized | 94.07 |
| Discovery InstituteEIN 91-1521697 | Research and Public Policy | WA | $5,325,118Mid-sized | 82.97 |
| Discovery WorldEIN 39-1691578 | Arts, Culture, Humanities | WI | $9,457,339Mid-sized | 90.71 |
| District of Columbia College Access ProgramEIN 52-2132835 | Education | DC | $7,157,083Mid-sized | 86.80 |
| Do SomethingEIN 13-3720473 | Human Services | NY | $10,095,721Mid-sized | 93.37 |
| Doernbecher Children's Hospital FoundationEIN 93-0579589 | Health | OR | $12,481,925Mid-sized | 83.50 |
| Domestic Violence Intervention Services, Inc. (DVIS)EIN 73-1028332 | Human Services | OK | $6,638,122Mid-sized | 93.99 |
| Doorways for Women and FamiliesEIN 54-1087829 | Human Services | VA | $4,770,512Mid-sized | 93.46 |
| DOROTEIN 13-3264005 | Human Services | NY | $7,626,167Mid-sized | 92.96 |
| DoveLewis Emergency Animal HospitalEIN 93-0621534 | Animals | OR | $12,932,704Mid-sized | 86.84 |
| Downtown Cleveland AllianceEIN 34-1775903 | Community Development | OH | $7,152,083Mid-sized | 81.88 |
| Downtown Rescue MissionEIN 63-0735295 | Human Services | AL | $8,473,047Mid-sized | 90.69 |
| Downtown Women's CenterEIN 31-1597223 | Human Services | CA | $10,092,147Mid-sized | 89.78 |
| Dream FoundationEIN 77-0405779 | Health | CA | $4,761,331Mid-sized | 94.27 |
| DreamYard ProjectEIN 13-3759661 | Education | NY | $5,082,563Mid-sized | 86.67 |
| Drugs for Neglected Diseases Initiative North AmericaEIN 20-8774179 | Health | NY | $4,091,229Mid-sized | 84.44 |
| Dubuque County Historical SocietyEIN 42-6072050 | Arts, Culture, Humanities | IA | $7,001,981Mid-sized | 90.87 |
| DuPage Children's MuseumEIN 36-3565001 | Arts, Culture, Humanities | IL | $3,932,978Mid-sized | 84.78 |