| Imperial Valley Food PantryEIN 33-0633364 | Human Services | CA | $3,817,323Mid-sized | 71.17 |
| In Touch FoundationEIN 58-2054582 | Religion | GA | $4,610,654Mid-sized | 85.55 |
| Independence Seaport MuseumEIN 23-1584971 | Arts, Culture, Humanities | PA | $5,018,524Mid-sized | 81.35 |
| India Community CenterEIN 52-2351119 | Human Services | CA | $4,360,944Mid-sized | 71.51 |
| India Gospel League, North AmericaEIN 31-1423556 | Religion | OH | $3,563,796Mid-sized | 93.77 |
| Indian Muslim Relief and CharitiesEIN 27-0058132 | International | CA | $5,886,673Mid-sized | 94.74 |
| Indian River Habitat for HumanityEIN 65-0230079 | Community Development | FL | $5,733,247Mid-sized | 92.16 |
| Indiana Black Expo, Inc.EIN 35-1406245 | Community Development | IN | $4,658,463Mid-sized | 78.18 |
| Indiana Historical SocietyEIN 35-0876384 | Arts, Culture, Humanities | IN | $12,091,643Mid-sized | 83.95 |
| Indiana Repertory TheatreEIN 35-1186290 | Arts, Culture, Humanities | IN | $7,233,067Mid-sized | 88.31 |
| Infant Welfare Society of ChicagoEIN 36-2167752 | Health | IL | $9,544,302Mid-sized | 90.93 |
| Initiative for A Competitive Inner CityEIN 13-3772904 | Community Development | MA | $4,348,578Mid-sized | 97.05 |
| Initiative FoundationEIN 36-3451562 | Community Development | MN | $7,323,711Mid-sized | 92.11 |
| Inland Empire United WayEIN 33-0502676 | Community Development | CA | $6,839,548Mid-sized | 97.87 |
| INMED Partnerships for ChildrenEIN 52-1482339 | International | VA | $11,283,378Mid-sized | 95.04 |
| Inner City Christian FederationEIN 38-1903026 | Community Development | MI | $3,981,359Mid-sized | 80.42 |
| Inner City Health CenterEIN 74-2426085 | Health | CO | $4,248,776Mid-sized | 85.49 |
| Inner City Law CenterEIN 95-3697572 | Human and Civil Rights | CA | $4,036,319Mid-sized | 93.16 |
| Inner-City ArtsEIN 95-4239478 | Education | CA | $3,939,718Mid-sized | 90.71 |
| Inspiration CorporationEIN 36-3673980 | Human Services | IL | $3,630,945Mid-sized | 84.09 |
| Institute for Creation ResearchEIN 95-3523177 | Religion | TX | $7,585,130Mid-sized | 93.85 |
| Institute for Policy StudiesEIN 52-0788947 | Research and Public Policy | DC | $3,889,771Mid-sized | 94.21 |
| Institute for Quality EducationEIN 35-1836687 | Education | IN | $9,090,608Mid-sized | 86.44 |
| Institute for Transportation and Development PolicyEIN 52-1399520 | Environment | NY | $7,664,135Mid-sized | 87.62 |
| Institute of Noetic SciencesEIN 23-7236986 | Research and Public Policy | CA | $5,024,895Mid-sized | 87.56 |
| InterActionEIN 13-3287064 | International | DC | $9,733,199Mid-sized | 91.01 |
| Intercollegiate Studies InstituteEIN 23-6050131 | Education | DE | $7,276,782Mid-sized | 94.89 |
| Interfaith Community Services of Pima CountyEIN 86-0520997 | Human Services | AZ | $5,912,357Mid-sized | 98.23 |
| Interfaith Community Services, CaliforniaEIN 95-3837714 | Human Services | CA | $12,774,551Mid-sized | 92.90 |
| Interfaith Food PantryEIN 22-3618468 | Human Services | NJ | $4,115,577Mid-sized | 94.06 |
| Interfaith Outreach & Community PartnersEIN 36-3482724 | Human Services | MN | $8,323,002Mid-sized | 96.92 |
| Interfaith WorksEIN 52-1072684 | Human Services | MD | $12,337,425Mid-sized | 84.98 |
| Interfaith Youth CoreEIN 30-0212534 | Religion | IL | $6,458,253Mid-sized | 89.33 |
| International Center for JournalistsEIN 11-2724905 | International | DC | $12,304,327Mid-sized | 97.75 |
| International Center for Research on WomenEIN 52-1081455 | International | DC | $12,380,625Mid-sized | 83.72 |
| International Children's CareEIN 93-0717332 | International | WA | $4,074,715Mid-sized | 90.60 |
| International CommissionEIN 75-1496922 | Religion | TX | $4,797,428Mid-sized | 78.31 |
| International Community FoundationEIN 33-0457858 | International | CA | $11,867,287Mid-sized | 97.17 |
| International Crane FoundationEIN 39-1187711 | Animals | WI | $6,849,740Mid-sized | 91.97 |
| International Disaster Emergency ServiceEIN 23-7348277 | International | IN | $5,624,560Mid-sized | 97.76 |
| International Eye FoundationEIN 52-0742301 | International | MD | $4,553,179Mid-sized | 81.58 |
| International Game Fish AssociationEIN 23-7231048 | Animals | FL | $4,387,685Mid-sized | 76.60 |
| International Institute of Rural Reconstruction (IIRR)EIN 13-6175722 | International | NY | $4,270,136Mid-sized | 90.00 |
| International MessengersEIN 41-1652782 | Religion | IA | $4,549,161Mid-sized | 93.28 |
| International Mountain Bicycling AssociationEIN 47-1254119 | Human Services | CO | $3,932,971Mid-sized | 80.31 |
| International Peace InstituteEIN 03-0213226 | International | NY | $9,589,196Mid-sized | 95.34 |
| International Rett Syndrome FoundationEIN 31-1682518 | Health | OH | $5,001,314Mid-sized | 91.42 |
| International Tennis Hall of FameEIN 13-6144356 | Arts, Culture, Humanities | RI | $10,386,956Mid-sized | 85.30 |
| International Women's Health CoalitionEIN 23-7378153 | International | NY | $6,565,003Mid-sized | 94.76 |
| InterServe USAEIN 23-1644377 | Religion | PA | $6,078,115Mid-sized | 85.85 |
| Iona Senior ServicesEIN 52-1039553 | Human Services | DC | $4,589,586Mid-sized | 94.78 |
| Iowa State University Alumni AssociationEIN 42-6062614 | Education | IA | $4,416,820Mid-sized | 86.24 |
| Iranian American Jewish Federation of New YorkEIN 01-0651843 | Community Development | NY | $4,104,978Mid-sized | 98.23 |
| Iraq and Afghanistan Veterans of AmericaEIN 20-1664531 | Human and Civil Rights | NY | $7,230,821Mid-sized | 79.98 |
| Island InstituteEIN 22-2786731 | Community Development | ME | $5,392,897Mid-sized | 78.89 |
| Island PressEIN 94-2578166 | Environment | DC | $4,526,796Mid-sized | 89.27 |
| IslandWoodEIN 31-1654076 | Education | WA | $9,854,727Mid-sized | 90.56 |
| Israel Cancer Research FundEIN 51-0181215 | Health | NY | $4,379,201Mid-sized | 80.22 |
| Israel Guide Dog Center for the BlindEIN 23-2519029 | Animals | PA | $3,959,395Mid-sized | 100.00 |
| Israel Tennis Centers Foundation EIN 13-2961273 | Human Services | NY | $5,681,128Mid-sized | 87.01 |