| Special Olympics GeorgiaEIN 23-7201676 | Human Services | GA | $3,924,681Mid-sized | 87.01 |
| Special Olympics IllinoisEIN 36-2922811 | Human Services | IL | $9,727,839Mid-sized | 93.81 |
| Special Olympics IndianaEIN 35-1262574 | Human Services | IN | $4,170,414Mid-sized | 90.61 |
| Special Olympics MarylandEIN 23-7089144 | Human Services | MD | $4,631,154Mid-sized | 89.88 |
| Special Olympics MassachusettsEIN 23-7242294 | Human Services | MA | $4,403,489Mid-sized | 82.89 |
| Special Olympics MinnesotaEIN 41-1228157 | Human Services | MN | $6,699,150Mid-sized | 87.44 |
| Special Olympics MissouriEIN 23-7328374 | Human Services | MO | $4,342,896Mid-sized | 88.50 |
| Special Olympics New JerseyEIN 23-7448729 | Human Services | NJ | $7,620,689Mid-sized | 93.32 |
| Special Olympics North CarolinaEIN 56-1149607 | Human Services | NC | $4,726,674Mid-sized | 92.74 |
| Special Olympics of PennsylvaniaEIN 23-2078543 | Human Services | PA | $7,444,959Mid-sized | 90.34 |
| Special Olympics OregonEIN 93-0752969 | Human Services | OR | $4,858,280Mid-sized | 73.03 |
| Special Olympics Southern CaliforniaEIN 95-4538450 | Human Services | CA | $11,029,255Mid-sized | 97.23 |
| Special Olympics TexasEIN 74-1998367 | Human Services | TX | $9,080,131Mid-sized | 86.84 |
| Special Olympics VirginiaEIN 54-1013637 | Human Services | VA | $4,833,080Mid-sized | 89.91 |
| Special Olympics WashingtonEIN 91-0962383 | Human Services | WA | $4,115,372Mid-sized | 85.40 |
| Special Olympics WisconsinEIN 39-1176591 | Human Services | WI | $4,554,211Mid-sized | 82.06 |
| Special Operations Warrior FoundationEIN 52-1183585 | Education | FL | $11,730,490Mid-sized | 94.47 |
| Speedway Children's CharitiesEIN 56-1331429 | Education | NC | $3,925,136Mid-sized | 86.80 |
| Spence-Chapin Services to Families and ChildrenEIN 13-1834590 | Human Services | NY | $7,266,046Mid-sized | 81.35 |
| Spirit of AmericaEIN 20-1687786 | International | VA | $3,626,101Mid-sized | 96.83 |
| Spokane County United WayEIN 91-0606058 | Community Development | WA | $4,118,437Mid-sized | 86.72 |
| Spoleto Festival USAEIN 57-0660848 | Arts, Culture, Humanities | SC | $8,737,036Mid-sized | 82.85 |
| Spread the Word NevadaEIN 22-3829041 | Education | NV | $3,504,067Mid-sized | 98.23 |
| Springfield Library and Museums AssociationEIN 04-6002239 | Arts, Culture, Humanities | MA | $7,616,989Mid-sized | 87.57 |
| Springfield Rescue MissionEIN 52-1047790 | Human Services | MA | $5,894,186Mid-sized | 80.93 |
| Springs Rescue MissionEIN 84-1340824 | Human Services | CO | $11,053,485Mid-sized | 87.91 |
| SPUREIN 94-1498232 | Research and Public Policy | CA | $6,462,777Mid-sized | 88.07 |
| St. Ann's Center for Children, Youth and FamiliesEIN 53-0204626 | Human Services | MD | $4,519,774Mid-sized | 90.31 |
| St. Francis HouseEIN 22-2519129 | Human Services | MA | $8,991,131Mid-sized | 83.47 |
| St. Hubert's Animal Welfare CenterEIN 22-1627726 | Animals | NJ | $5,921,842Mid-sized | 98.16 |
| St. John's Bread & LifeEIN 11-3174514 | Human Services | NY | $4,064,642Mid-sized | 89.71 |
| St. Joseph Food ProgramEIN 39-1822486 | Human Services | WI | $6,098,206Mid-sized | 66.71 |
| St. Matthew's HouseEIN 65-1110501 | Human Services | FL | $7,624,221Mid-sized | 92.14 |
| St. Petersburg Free ClinicEIN 23-7208280 | Health | FL | $12,323,655Mid-sized | 97.17 |
| St. Rita School for the DeafEIN 31-0537509 | Education | OH | $6,147,225Mid-sized | 87.66 |
| St. Vincent de Paul of Seattle|King CountyEIN 91-0583891 | Human Services | WA | $10,749,665Mid-sized | 85.01 |
| St. Vincent de Paul Society of Marin CountyEIN 94-1207701 | Human Services | CA | $4,107,059Mid-sized | 96.42 |
| St. Vincent Meals on WheelsEIN 95-3696693 | Human Services | CA | $8,085,613Mid-sized | 86.11 |
| Stamford Center for the ArtsEIN 06-1048684 | Arts, Culture, Humanities | CT | $3,601,344Mid-sized | 86.08 |
| Stan Hywet Hall & GardensEIN 34-0819149 | Arts, Culture, Humanities | OH | $5,263,087Mid-sized | 73.90 |
| StandWithUsEIN 01-0566033 | International | CA | $12,583,673Mid-sized | 95.47 |
| Stanley M. Isaacs Neighborhood CenterEIN 13-2572034 | Human Services | NY | $7,899,036Mid-sized | 86.21 |
| Starlight Children's FoundationEIN 95-3802159 | Health | CA | $9,806,057Mid-sized | 93.94 |
| STARSEIN 62-1285699 | Human Services | TN | $3,850,505Mid-sized | 91.27 |
| State Policy NetworkEIN 57-0952531 | Research and Public Policy | VA | $12,797,260Mid-sized | 88.07 |
| State University College at Oneonta Foundation CorporationEIN 22-2403203 | Education | NY | $3,696,700Mid-sized | 92.96 |
| Steadman Philippon Research InstituteEIN 88-0245022 | Health | CO | $10,428,427Mid-sized | 86.07 |
| Step UpEIN 95-4701468 | Human Services | CA | $4,222,065Mid-sized | 95.14 |
| Stephen CenterEIN 36-3363994 | Human Services | NE | $3,889,802Mid-sized | 89.24 |
| Stephens Family YMCAEIN 37-0673564 | Human Services | IL | $5,276,013Mid-sized | 86.80 |
| Storefront Academy HarlemEIN 13-2940671 | Education | NY | $3,785,092Mid-sized | 79.48 |
| Storm King Art CenterEIN 14-1457573 | Arts, Culture, Humanities | NY | $8,396,023Mid-sized | 89.00 |
| StoryCorpsEIN 13-3753011 | Arts, Culture, Humanities | NY | $10,638,243Mid-sized | 94.93 |
| StrathmoreEIN 52-1233092 | Arts, Culture, Humanities | MD | $12,121,219Mid-sized | 90.00 |
| STRIVEEIN 13-3255679 | Human Services | NY | $6,254,660Mid-sized | 88.95 |
| Strong City BaltimoreEIN 52-0897806 | Human Services | MD | $11,112,362Mid-sized | 90.71 |
| Stroud Water Research CenterEIN 52-2081073 | Environment | PA | $9,504,082Mid-sized | 91.98 |
| Student Leadership NetworkEIN 06-1517218 | Education | NY | $9,472,942Mid-sized | 92.02 |
| Student Sponsor PartnersEIN 13-3392965 | Education | NY | $7,283,038Mid-sized | 91.46 |
| Students InternationalEIN 77-0410440 | Religion | CA | $4,549,657Mid-sized | 88.40 |