| Students Rising AboveEIN 81-0615887 | Education | CA | $4,271,682Mid-sized | 90.42 |
| Studio in a SchoolEIN 13-3003112 | Education | NY | $6,718,983Mid-sized | 88.27 |
| Studio Museum in HarlemEIN 13-2590805 | Arts, Culture, Humanities | NY | $7,761,083Mid-sized | 88.58 |
| Summit Academy OICEIN 41-0908458 | Education | MN | $7,997,922Mid-sized | 93.46 |
| Summit Speech SchoolEIN 22-1829502 | Education | NJ | $4,019,719Mid-sized | 75.56 |
| Sun Devil ClubEIN 86-0138459 | Education | AZ | $12,238,895Mid-sized | 82.26 |
| Sunday Breakfast MissionEIN 51-0073080 | Human Services | DE | $5,615,126Mid-sized | 79.65 |
| Sunnyvale Community ServicesEIN 94-1713897 | Human Services | CA | $7,426,109Mid-sized | 95.10 |
| Sunshine Division Portland Police DeptEIN 93-0429354 | Human Services | OR | $5,667,244Mid-sized | 90.89 |
| Support Center for Child AdvocatesEIN 23-2048664 | Human and Civil Rights | PA | $3,549,961Mid-sized | 91.29 |
| Surrey Services for SeniorsEIN 23-2610145 | Human Services | PA | $4,603,921Mid-sized | 91.37 |
| Susan B. Anthony Recovery CenterEIN 65-0583089 | Human Services | FL | $3,840,666Mid-sized | 79.43 |
| Sustainable ConservationEIN 94-3232437 | Environment | CA | $5,612,199Mid-sized | 88.59 |
| Swim Across AmericaEIN 22-3248256 | Health | NC | $6,543,494Mid-sized | 85.42 |
| Symphony Silicon ValleyEIN 32-0083030 | Arts, Culture, Humanities | CA | $3,744,844Mid-sized | 83.56 |
| Symphony SpaceEIN 13-2941455 | Arts, Culture, Humanities | NY | $6,686,548Mid-sized | 91.83 |
| Syracuse StageEIN 15-0623468 | Arts, Culture, Humanities | NY | $5,682,361Mid-sized | 84.78 |
| Taco Bell FoundationEIN 33-0523542 | Education | CA | $9,729,593Mid-sized | 91.14 |
| Tacoma Art MuseumEIN 91-0697444 | Arts, Culture, Humanities | WA | $5,952,363Mid-sized | 86.03 |
| Tahirih Justice CenterEIN 54-1858176 | Human and Civil Rights | VA | $7,001,173Mid-sized | 88.40 |
| Take Stock in ChildrenEIN 59-3331584 | Education | FL | $8,938,574Mid-sized | 87.88 |
| Taking Control of Your DiabetesEIN 33-0794608 | Health | CA | $4,188,227Mid-sized | 91.45 |
| Talmudic Research Center of Northern New JerseyEIN 22-2041389 | Religion | NJ | $4,075,452Mid-sized | 63.18 |
| Taproot FoundationEIN 91-2162645 | Human and Civil Rights | CA | $4,241,464Mid-sized | 76.63 |
| Target HungerEIN 31-1548849 | Human Services | TX | $9,610,145Mid-sized | 83.45 |
| Taubman Museum of ArtEIN 54-6026841 | Arts, Culture, Humanities | VA | $4,213,597Mid-sized | 88.16 |
| Tax FoundationEIN 52-1703065 | Research and Public Policy | DC | $4,178,093Mid-sized | 84.96 |
| Teach Plus IncorporatedEIN 26-3849472 | Education | MA | $7,266,089Mid-sized | 87.51 |
| Teaching MattersEIN 13-3770472 | Education | NY | $6,009,669Mid-sized | 94.45 |
| Team RubiconEIN 27-1720480 | International | CA | $11,426,753Mid-sized | 91.42 |
| TechbridgeEIN 58-2531971 | Education | GA | $3,568,642Mid-sized | 85.23 |
| Teen Challenge New England & New JerseyEIN 04-2401399 | Health | MA | $8,074,836Mid-sized | 86.49 |
| Teen Challenge of Southern CaliforniaEIN 95-2683852 | Health | CA | $11,965,819Mid-sized | 90.26 |
| Teen Challenge of TexasEIN 74-1816616 | Health | TX | $3,937,957Mid-sized | 78.25 |
| Telfair Museum of ArtEIN 58-0610074 | Arts, Culture, Humanities | GA | $6,217,237Mid-sized | 85.62 |
| TenacityEIN 04-3452763 | Education | MA | $4,319,459Mid-sized | 83.94 |
| Texas Ballet TheaterEIN 84-1622654 | Arts, Culture, Humanities | TX | $8,289,958Mid-sized | 86.07 |
| Texas Parks and Wildlife FoundationEIN 74-2602504 | Environment | TX | $6,241,257Mid-sized | 95.05 |
| Texas Public Policy FoundationEIN 74-2524057 | Research and Public Policy | TX | $8,681,038Mid-sized | 91.89 |
| Texas Public RadioEIN 74-2559514 | Arts, Culture, Humanities | TX | $4,888,453Mid-sized | 95.17 |
| Texas Tech Alumni AssociationEIN 75-6036607 | Education | TX | $3,700,697Mid-sized | 68.72 |
| TGR Foundation, A Tiger Woods CharityEIN 20-0677815 | Human Services | CA | $11,035,526Mid-sized | 93.03 |
| The Admiral Nimitz FoundationEIN 74-1492692 | Arts, Culture, Humanities | TX | $6,005,614Mid-sized | 96.37 |
| The Adoption ExchangeEIN 84-0793576 | Human Services | CO | $3,915,626Mid-sized | 82.34 |
| The Aleph InstituteEIN 59-2291627 | Human Services | FL | $3,717,868Mid-sized | 80.10 |
| The ALS Association Golden West ChapterEIN 95-4163338 | Health | CA | $4,752,423Mid-sized | 92.85 |
| The ALS Association Greater New York ChapterEIN 13-3616680 | Health | NY | $5,132,118Mid-sized | 97.66 |
| The ALS Association, Greater Philadelphia ChapterEIN 23-2387205 | Health | PA | $5,699,754Mid-sized | 87.34 |
| The American Committee for the Tel Aviv FoundationEIN 13-3145161 | International | NY | $3,796,330Mid-sized | 89.50 |
| The Anti-Cruelty SocietyEIN 36-2179814 | Animals | IL | $8,771,665Mid-sized | 91.30 |
| The ARK ChicagoEIN 23-7164967 | Human Services | IL | $6,505,527Mid-sized | 90.71 |
| The Armory FoundationEIN 13-3680286 | Human Services | NY | $6,815,239Mid-sized | 94.66 |
| The Association for Frontotemporal DegenerationEIN 41-2073220 | Health | PA | $4,610,207Mid-sized | 97.82 |
| The Atlanta OperaEIN 58-1371843 | Arts, Culture, Humanities | GA | $6,915,902Mid-sized | 84.42 |
| The Avon FoundationEIN 13-6128447 | Health | NY | $9,254,623Mid-sized | 72.73 |
| The Ayn Rand InstituteEIN 22-2570926 | Research and Public Policy | CA | $9,513,258Mid-sized | 76.96 |
| The Blue Army of Our Lady of Fatima, U.S.A.EIN 22-2297353 | Religion | NJ | $3,599,362Mid-sized | 85.61 |
| The Blue CardEIN 13-1623910 | Human Services | NY | $4,188,918Mid-sized | 94.13 |
| The Boomer Esiason FoundationEIN 11-3142753 | Health | NY | $6,494,763Mid-sized | 95.63 |
| The Boys' Club of New YorkEIN 13-5591750 | Human Services | NY | $12,451,748Mid-sized | 88.24 |