| Caring Voice CoalitionEIN 26-0058446 | Health | VA | $87,769,321Large | 89.20 |
| CaringBridgeEIN 42-1529394 | Health | MN | $7,318,728Mid-sized | 81.08 |
| CaringWorksEIN 56-2370081 | Human Services | GA | $6,142,050Mid-sized | 90.94 |
| CARITASEIN 54-1441917 | Human Services | VA | $3,295,879Small | 92.44 |
| Caritas of AustinEIN 74-1909670 | Human Services | TX | $12,546,415Mid-sized | 87.34 |
| Carmel FoundationEIN 94-1225368 | Human Services | CA | $2,544,823Small | 82.50 |
| Carnegie Council for Ethics in International AffairsEIN 13-1573954 | International | NY | $3,528,670Mid-sized | 81.55 |
| Carnegie Endowment for International PeaceEIN 13-0552040 | International | DC | $36,544,639Large | 86.94 |
| Carnegie Institution for ScienceEIN 53-0196523 | Research and Public Policy | DC | $100,297,805Large | 87.74 |
| Carnegie Museums of PittsburghEIN 25-0965280 | Arts, Culture, Humanities | PA | $60,885,821Large | 86.59 |
| Carolina BalletEIN 56-1445383 | Arts, Culture, Humanities | NC | $5,871,426Mid-sized | 89.69 |
| Carolina for KiberaEIN 56-2248495 | International | NC | $688,361Small | 90.05 |
| Carolina Raptor CenterEIN 56-1349170 | Animals | NC | $1,346,881Small | 87.96 |
| Carpenter's ShelterEIN 54-1571849 | Human Services | VA | $2,133,586Small | 88.40 |
| CARPLSEIN 36-3863573 | Human and Civil Rights | IL | $2,056,206Small | 90.17 |
| Carriage Town MinistriesEIN 38-1443378 | Human Services | MI | $2,568,726Small | 92.72 |
| Carson Scholars FundEIN 52-1851346 | Education | MD | $1,967,187Small | 90.00 |
| Cary Christian CenterEIN 64-0781589 | Human Services | MS | $914,934Small | 78.36 |
| Cary Institute of Ecosystem StudiesEIN 22-3232968 | Research and Public Policy | NY | $13,031,409Mid-sized | 94.32 |
| Casa De AmigosEIN 75-1240087 | Human Services | TX | $995,709Small | 88.72 |
| Casa de AmparoEIN 95-3315571 | Human Services | CA | $8,748,510Mid-sized | 96.46 |
| Casa de Esperanza de Los NinosEIN 76-0105306 | Human Services | TX | $3,933,307Mid-sized | 89.53 |
| Casa de MarylandEIN 52-1372972 | Education | MD | $9,534,556Mid-sized | 83.76 |
| CASA of Los AngelesEIN 95-3890446 | Human Services | CA | $3,600,000Mid-sized | 80.49 |
| CASA of the Pikes Peak RegionEIN 84-1115548 | Human Services | CO | $2,121,059Small | 90.78 |
| CASA of Travis CountyEIN 74-2369123 | Human Services | TX | $3,877,348Mid-sized | 91.53 |
| Casa TeresaEIN 95-3251986 | Human Services | CA | $2,588,883Small | 82.72 |
| Casas Por CristoEIN 74-2679881 | International | TX | $3,458,456Small | 82.51 |
| Cascade AIDS ProjectEIN 93-0903383 | Health | OR | $7,017,544Mid-sized | 86.00 |
| Casita MariaEIN 13-1623994 | Human Services | NY | $3,239,288Small | 88.21 |
| Casting for RecoveryEIN 03-0354382 | Health | MT | $1,529,836Small | 97.72 |
| Castleton Ranch Horse Rescue Inc.EIN 11-3731839 | Animals | CA | $1,611,503Small | 78.53 |
| Cat Adoption TeamEIN 20-0773189 | Animals | OR | $1,840,044Small | 89.24 |
| Cat Care SocietyEIN 84-0869447 | Animals | CO | $1,009,674Small | 91.82 |
| CATCH Neighborhood HousingEIN 02-0433505 | Community Development | NH | $1,696,293Small | 88.23 |
| Catch-A-Dream FoundationEIN 20-0487728 | Health | MS | $873,893Small | 84.60 |
| Cathedral Arts ProjectEIN 59-3672453 | Human Services | FL | $1,546,620Small | 88.36 |
| Cathedral KitchenEIN 22-3114500 | Human Services | NJ | $3,809,168Mid-sized | 98.23 |
| Catholic AnswersEIN 95-3754404 | Religion | CA | $7,475,369Mid-sized | 74.63 |
| Catholic Big Sisters & Big BrothersEIN 13-5564115 | Human Services | NY | $1,235,856Small | 87.63 |
| Catholic Charities Archdiocese of New OrleansEIN 72-0408911 | Human Services | LA | $25,374,533Large | 87.30 |
| Catholic Charities AtlantaEIN 58-1097003 | Human Services | GA | $5,894,054Mid-sized | 86.38 |
| Catholic Charities CYO, Archdiocese of San FranciscoEIN 94-1498472 | Community Development | CA | $39,675,865Large | 91.21 |
| Catholic Charities Diocese of ClevelandEIN 34-1318541 | Human Services | OH | $94,796,377Large | 86.67 |
| Catholic Charities Diocese of St. PetersburgEIN 59-0875805 | Human Services | FL | $14,146,994Large | 90.63 |
| Catholic Charities Fort WorthEIN 75-0808769 | Human Services | TX | $36,791,584Large | 97.23 |
| Catholic Charities of BaltimoreEIN 52-0591538 | Human Services | MD | $110,847,148Large | 87.17 |
| Catholic Charities of BuffaloEIN 16-0743251 | Human Services | NY | $34,668,837Large | 91.01 |
| Catholic Charities of Los AngelesEIN 95-1690973 | Human Services | CA | $38,301,614Large | 96.16 |
| Catholic Charities of Northeast KansasEIN 48-1181305 | Human Services | KS | $25,350,672Large | 91.16 |
| Catholic Charities of Northern NevadaEIN 88-0339754 | Human Services | NV | $13,099,433Mid-sized | 91.45 |
| Catholic Charities of Santa Clara CountyEIN 94-2762269 | Human Services | CA | $35,534,021Large | 87.91 |
| Catholic Charities of Southern MinnesotaEIN 41-0721636 | Human Services | MN | $2,840,617Small | 93.42 |
| Catholic Charities of SpokaneEIN 91-0569880 | Human Services | WA | $16,225,818Large | 90.52 |
| Catholic Charities of St. Paul and MinneapolisEIN 41-1302487 | Human Services | MN | $50,683,237Large | 92.01 |
| Catholic Charities of the Archdiocese of Galveston-HoustonEIN 74-1109733 | Human Services | TX | $38,475,867Large | 93.20 |
| Catholic Charities of the Archdiocese of MilwaukeeEIN 39-0806321 | Human Services | WI | $6,103,750Mid-sized | 90.64 |
| Catholic Charities of the Archdiocese of Oklahoma CityEIN 73-0636561 | Human Services | OK | $8,014,721Mid-sized | 90.76 |
| Catholic Charities of the Archdiocese of OmahaEIN 47-0376612 | Human Services | NE | $5,110,419Mid-sized | 86.53 |
| Catholic Charities of the Diocese of FresnoEIN 94-1678938 | Human Services | CA | $5,994,629Mid-sized | 91.18 |