| Catholic Charities of the Diocese of Santa RosaEIN 94-2479393 | Human Services | CA | $13,533,849Large | 90.17 |
| Catholic Charities of the East BayEIN 94-2677202 | Human Services | CA | $6,682,589Mid-sized | 79.64 |
| Catholic Charities Southwestern OhioEIN 31-0536968 | Human Services | OH | $16,836,807Large | 87.22 |
| Catholic Charities, Archdiocese of DenverEIN 84-0686679 | Human Services | CO | $25,590,589Large | 95.04 |
| Catholic Charities, Archdiocese of St. LouisEIN 43-0653270 | Human Services | MO | $7,104,722Mid-sized | 95.47 |
| Catholic Charities, Diocese of NorwichEIN 06-0646609 | Human Services | CT | $2,105,175Small | 80.10 |
| Catholic Charities, Diocese of Venice, Inc.EIN 59-2473176 | Human Services | FL | $7,936,897Mid-sized | 90.71 |
| Catholic Community FoundationEIN 34-1908579 | Human Services | OH | $18,059,323Large | 80.25 |
| Catholic Community Services of Lane CountyEIN 93-0409105 | Human Services | OR | $4,582,187Mid-sized | 92.56 |
| Catholic Education ArizonaEIN 86-0937587 | Education | AZ | $18,380,089Large | 83.46 |
| Catholic Foundation of MaineEIN 77-0612679 | Religion | ME | $1,303,373Small | 75.35 |
| Catholic Health Initiatives Colorado FoundationEIN 84-0902211 | Health | CO | $24,601,571Large | 81.46 |
| Catholic League for Religious and Civil RightsEIN 23-7279981 | Human and Civil Rights | NY | $3,045,051Small | 77.40 |
| Catholic Legal Immigration Network. Inc. (CLINIC)EIN 52-1584951 | Human and Civil Rights | MD | $6,944,953Mid-sized | 97.17 |
| Catholic Medical Mission BoardEIN 13-5602319 | International | NY | $581,681,284Large | 97.87 |
| Catholic Near East Welfare Association (CNEWA)EIN 13-1623929 | Religion | NY | $25,303,965Large | 95.54 |
| Catholic Schools FoundationEIN 22-2485502 | Education | MA | $11,109,378Mid-sized | 96.08 |
| Catholic Social Services of AnchorageEIN 92-0037322 | Human Services | AK | $10,584,775Mid-sized | 93.25 |
| Catholic Social Services of ColumbusEIN 31-4379437 | Human Services | OH | $4,873,241Mid-sized | 96.10 |
| Catholic Social Services of Southern NebraskaEIN 47-0751554 | Human Services | NE | $6,160,111Mid-sized | 86.04 |
| Catholics for ChoiceEIN 52-1154418 | Human and Civil Rights | DC | $3,487,440Small | 93.10 |
| Catholics United for the FaithEIN 13-2621966 | Religion | OH | $125,191Small | 59.24 |
| CatholicTVEIN 04-2395520 | Religion | MA | $9,283,767Mid-sized | 80.75 |
| Catskill Animal SanctuaryEIN 14-1827972 | Animals | NY | $2,104,076Small | 96.35 |
| Caucus Educational CorporationEIN 22-3240680 | Arts, Culture, Humanities | NJ | $3,841,946Mid-sized | 74.88 |
| CBMCEIN 36-2004402 | Religion | TN | $9,309,673Mid-sized | 83.97 |
| CBMC InternationalEIN 58-1744271 | Religion | AZ | $580,511Small | 79.83 |
| CDC FoundationEIN 58-2106707 | Health | GA | $91,221,521Large | 98.23 |
| CEAPEIN 41-0990340 | Human Services | MN | $4,193,723Mid-sized | 85.73 |
| CEC ArtsLinkEIN 13-2531695 | International | NY | $724,948Small | 82.05 |
| CEC/Seabee Historical FoundationEIN 58-1998577 | Arts, Culture, Humanities | MS | $1,608,841Small | 65.63 |
| Cedar Valley Habitat for HumanityEIN 42-1320296 | Community Development | IA | $2,697,820Small | 90.08 |
| Cedar Valley United WayEIN 42-0801846 | Community Development | IA | $2,470,131Small | 88.50 |
| CEDARSEIN 47-6024881 | Human Services | NE | $12,918,567Mid-sized | 95.72 |
| Celebrity Fight Night FoundationEIN 86-0903119 | Health | AZ | $2,720,093Small | 74.05 |
| Celebrity Series of BostonEIN 22-2958508 | Arts, Culture, Humanities | MA | $7,898,914Mid-sized | 91.75 |
| Cell Phones For SoldiersEIN 20-1343425 | Human Services | MA | $559,483Small | 66.97 |
| Cenikor FoundationEIN 76-0031861 | Health | TX | $20,080,690Large | 93.59 |
| Center for a New American SecurityEIN 20-8084828 | Research and Public Policy | DC | $9,751,151Mid-sized | 96.54 |
| Center for Action and ContemplationEIN 85-0354965 | Religion | NM | $5,261,149Mid-sized | 91.09 |
| Center for American ProgressEIN 30-0126510 | Research and Public Policy | DC | $46,765,901Large | 91.15 |
| Center for Arizona PolicyEIN 86-0618922 | Human and Civil Rights | AZ | $1,965,515Small | 88.30 |
| Center for Arms Control and Non-ProliferationEIN 04-2693322 | Human and Civil Rights | DC | $905,915Small | 85.56 |
| Center for Arts EducationEIN 13-3938080 | Education | NY | $2,749,501Small | 81.74 |
| Center for Arts-Inspired LearningEIN 34-1241756 | Education | OH | $1,786,799Small | 83.36 |
| Center for Asian American MediaEIN 94-2801493 | Arts, Culture, Humanities | CA | $2,713,551Small | 90.39 |
| Center for Bio-Ethical ReformEIN 33-0443975 | Human and Civil Rights | CA | $982,157Small | 78.77 |
| Center for Biological Diversity EIN 27-3943866 | Environment | AZ | $17,996,339Large | 97.87 |
| Center for Child & Family ServicesEIN 54-0505893 | Human Services | VA | $1,647,899Small | 89.18 |
| Center for Child ProtectionEIN 74-2562585 | Human Services | TX | $5,770,355Mid-sized | 91.45 |
| Center for Children & Youth JusticeEIN 20-4457248 | Human and Civil Rights | WA | $2,216,576Small | 81.11 |
| Center for Children and FamiliesEIN 73-0933253 | Human Services | OK | $2,145,359Small | 92.65 |
| Center for Climate and Energy SolutionsEIN 54-1892252 | Research and Public Policy | VA | $4,316,838Mid-sized | 84.09 |
| Center for Coastal StudiesEIN 04-2609788 | Environment | MA | $3,586,500Mid-sized | 94.03 |
| Center for Collaborative EducationEIN 04-3241676 | Education | MA | $4,694,075Mid-sized | 84.78 |
| Center for Community ChangeEIN 52-0888113 | Community Development | DC | $17,680,880Large | 88.05 |
| Center for Constitutional RightsEIN 22-6082880 | Human and Civil Rights | NY | $10,523,997Mid-sized | 95.14 |
| Center For Consumer FreedomEIN 26-0006579 | Human and Civil Rights | DC | $3,930,347Mid-sized | 86.10 |
| Center for Creative EducationEIN 65-0594599 | Education | FL | $1,588,290Small | 98.23 |
| Center for Creative Land RecyclingEIN 94-3302410 | Environment | CA | $984,006Small | 89.40 |