| Central California Food BankEIN 77-0320851 | Human Services | CA | $65,008,490Large | 94.67 |
| Central Coast Alliance United for A Sustainable EconomyEIN 77-0578864 | Human and Civil Rights | CA | $1,051,634Small | 88.85 |
| Central Florida YMCAEIN 59-0624430 | Human Services | FL | $59,588,094Large | 85.96 |
| Central Florida Zoo & Botanical GardensEIN 59-1357197 | Animals | FL | $5,702,682Mid-sized | 92.50 |
| Central Illinois FoodbankEIN 37-1106465 | Human Services | IL | $18,256,991Large | 92.92 |
| Central Indiana Community FoundationEIN 35-1793680 | Community Development | IN | $27,466,633Large | 91.42 |
| Central Institute for the DeafEIN 43-0662456 | Education | MO | $7,510,069Mid-sized | 93.44 |
| Central Iowa Shelter & ServicesEIN 42-1394212 | Human Services | IA | $2,529,003Small | 90.09 |
| Central New York Community FoundationEIN 15-0626910 | Community Development | NY | $22,768,461Large | 97.89 |
| Central Ohio Diabetes AssociationEIN 31-6054100 | Health | OH | $1,223,080Small | 73.68 |
| Central Oklahoma Habitat for HumanityEIN 73-1305668 | Community Development | OK | $10,160,701Mid-sized | 91.18 |
| Central Park ConservancyEIN 13-3022855 | Environment | NY | $72,425,618Large | 94.20 |
| Central Pennsylvania Food BankEIN 23-2202250 | Human Services | PA | $83,599,202Large | 98.23 |
| Central ScholarshipEIN 52-6012589 | Education | MD | $1,899,217Small | 96.74 |
| Central Texas Food BankEIN 74-2217350 | Human Services | TX | $88,983,352Large | 96.46 |
| Central Union MissionEIN 53-0218650 | Human Services | DC | $16,421,755Large | 89.86 |
| Centre County United WayEIN 25-1215290 | Community Development | PA | $1,792,114Small | 91.96 |
| Centre Pompidou FoundationEIN 13-2941675 | Arts, Culture, Humanities | CA | $7,552,193Mid-sized | 92.22 |
| CentroEIN 41-1290349 | Human Services | MN | $1,493,898Small | 90.38 |
| Centro Legal De La RazaEIN 23-7181456 | Human and Civil Rights | CA | $5,659,231Mid-sized | 92.22 |
| Centurion MinistriesEIN 22-2563979 | Human and Civil Rights | NJ | $1,587,880Small | 92.25 |
| Cerebral PalsyEIN 39-0901265 | Health | WI | $6,080,335Mid-sized | 88.99 |
| Cerebral Palsy FoundationEIN 13-6093337 | Health | NY | $1,808,965Small | 82.51 |
| CeresEIN 22-3053747 | Environment | MA | $14,937,631Large | 96.52 |
| CERGE-EI FoundationEIN 25-1725738 | International | NJ | $3,260,105Small | 92.14 |
| CETEIN 31-0560051 | Arts, Culture, Humanities | OH | $5,016,398Mid-sized | 84.20 |
| CFES Brilliant PathwaysEIN 22-3159630 | Education | NY | $3,564,584Mid-sized | 84.83 |
| Chabad's Children of ChernobylEIN 13-3722594 | International | NY | $172,434Small | 58.25 |
| Chai LifelineEIN 11-2940331 | Human Services | NY | $19,233,028Large | 86.18 |
| Challenge AspenEIN 84-1315910 | Human Services | CO | $3,320,748Small | 100.00 |
| Challenged Athletes FoundationEIN 33-0739596 | Human Services | CA | $8,869,120Mid-sized | 84.16 |
| Challenged Child & FriendsEIN 58-1622732 | Education | GA | $2,311,777Small | 80.16 |
| Chamber Music AmericaEIN 13-2934575 | Arts, Culture, Humanities | NY | $2,826,648Small | 91.12 |
| Chamber Music NorthwestEIN 23-7355562 | Arts, Culture, Humanities | OR | $1,637,657Small | 95.38 |
| Chamber Music Society of Lincoln CenterEIN 13-2628036 | Arts, Culture, Humanities | NY | $8,916,142Mid-sized | 91.66 |
| Champaign County Humane SocietyEIN 37-0714217 | Animals | IL | $1,058,761Small | 85.28 |
| Changed LivesEIN 62-6081698 | Religion | TN | $1,145,541Small | 94.37 |
| Channel 3 Kids CampEIN 06-0660003 | Education | CT | $2,401,293Small | 70.71 |
| Channel Islands YMCAEIN 95-1643379 | Human Services | CA | $18,458,636Large | 90.64 |
| Channel One Regional Food BankEIN 41-1379713 | Human Services | MN | $15,937,633Large | 92.05 |
| Chapman PartnershipEIN 65-0425069 | Human Services | FL | $16,277,068Large | 95.11 |
| Chapman School of SeamanshipEIN 59-1416396 | Education | FL | $1,966,950Small | 76.20 |
| Charcot-Marie-Tooth AssociationEIN 22-2480896 | Health | PA | $2,539,687Small | 87.39 |
| Charity CarsEIN 59-3362703 | Human Services | FL | $7,458,283Mid-sized | 94.74 |
| Charity MotorsEIN 38-3251827 | Human Services | MI | $6,804,600Mid-sized | 54.61 |
| Charity NewsiesEIN 31-6401150 | Human Services | OH | $1,919,088Small | 94.28 |
| Charity VisionEIN 77-0222786 | International | UT | $11,957,329Mid-sized | 96.66 |
| charity: waterEIN 22-3936753 | International | NY | $35,902,241Large | 91.16 |
| Charles H. Wright Museum of African American HistoryEIN 38-1882096 | Arts, Culture, Humanities | MI | $6,275,367Mid-sized | 82.26 |
| Charles River Watershed AssociationEIN 04-6136989 | Environment | MA | $1,159,643Small | 76.43 |
| Charleston Animal SocietyEIN 57-6021863 | Animals | SC | $7,048,049Mid-sized | 94.16 |
| Charleston Symphony OrchestraEIN 57-6000192 | Arts, Culture, Humanities | SC | $3,490,071Small | 89.02 |
| Charleston Wine + Food FestivalEIN 20-2671674 | Arts, Culture, Humanities | SC | $3,135,643Small | 85.49 |
| Charlotte BalletEIN 58-1314711 | Arts, Culture, Humanities | NC | $7,537,739Mid-sized | 93.80 |
| Charlotte Family HousingEIN 58-1599120 | Human Services | NC | $3,197,515Small | 93.41 |
| Charlotte Rescue MissionEIN 56-0571223 | Human Services | NC | $6,345,655Mid-sized | 87.26 |
| Charlotte Symphony OrchestraEIN 56-6011568 | Arts, Culture, Humanities | NC | $9,930,801Mid-sized | 76.92 |
| Charlottesville Free ClinicEIN 54-1610405 | Health | VA | $4,215,026Mid-sized | 89.71 |
| Charlottesville-Albemarle SPCAEIN 54-0595009 | Animals | VA | $3,518,707Mid-sized | 86.45 |
| Chattahoochee RiverkeeperEIN 58-2095413 | Environment | GA | $2,483,987Small | 95.05 |