| Mission of MercyEIN 86-0704883 | Health | PA | $7,151,522Mid-sized | 93.89 |
| Mission PossibleEIN 34-1290940 | Religion | OH | $1,114,129Small | 84.18 |
| Mission to HaitiEIN 59-2173214 | International | FL | $667,035Small | 83.54 |
| Mission Waco Mission WorldEIN 74-2605621 | Religion | TX | $2,644,683Small | 98.01 |
| Mission Without BordersEIN 77-0292572 | International | CA | $1,198,470Small | 81.84 |
| Mission YearEIN 23-3005514 | Religion | IL | $735,526Small | 74.05 |
| Mission: HopeEIN 64-0866959 | International | GA | $2,410,206Small | 93.89 |
| Missionary Athletes InternationalEIN 33-0017152 | Religion | NC | $3,442,558Small | 83.18 |
| Missionary Aviation Repair CenterEIN 92-0032812 | Religion | AK | $2,511,792Small | 75.64 |
| Missionary Flights InternationalEIN 23-7199063 | Religion | FL | $4,326,147Mid-sized | 74.94 |
| Missionary Maintenance Service AviationEIN 31-0919027 | Religion | OH | $1,854,255Small | 81.53 |
| Mississippi Center for JusticeEIN 13-4203234 | Human and Civil Rights | MS | $3,606,434Mid-sized | 86.39 |
| Mississippi Children's MuseumEIN 64-0850010 | Arts, Culture, Humanities | MS | $3,541,158Mid-sized | 97.17 |
| Missoula Food BankEIN 81-0414143 | Human Services | MT | $4,608,782Mid-sized | 93.32 |
| Missouri Botanical GardenEIN 43-0666759 | Environment | MO | $45,210,838Large | 87.76 |
| Missouri History MuseumEIN 43-0654866 | Arts, Culture, Humanities | MO | $21,586,472Large | 97.14 |
| Missouri Slope Areawide United WayEIN 45-0387741 | Community Development | ND | $2,223,133Small | 91.83 |
| Mitchell InstituteEIN 01-0523390 | Education | ME | $2,338,190Small | 91.15 |
| MN Community MeasurementEIN 35-2246162 | Research and Public Policy | MN | $3,570,442Mid-sized | 83.18 |
| Mobile Loaves & FishesEIN 74-2956081 | Human Services | TX | $6,045,166Mid-sized | 98.23 |
| Mobile Meal Service of Spartanburg CountyEIN 57-0653452 | Human Services | SC | $2,170,786Small | 92.07 |
| Mobile Symphony OrchestraEIN 23-7070234 | Arts, Culture, Humanities | AL | $1,771,327Small | 70.16 |
| Mobius SpokaneEIN 91-1694299 | Arts, Culture, Humanities | WA | $1,677,935Small | 71.83 |
| Modest NeedsEIN 47-0863430 | Human Services | NY | $1,226,134Small | 83.84 |
| Modesto Gospel MissionEIN 94-6102833 | Human Services | CA | $6,196,894Mid-sized | 81.69 |
| Moffitt Cancer Center FoundationEIN 59-3238636 | Health | FL | $26,895,692Large | 82.04 |
| Mohawk Hudson Humane SocietyEIN 14-1338459 | Animals | NY | $3,033,879Small | 88.69 |
| Mohonk PreserveEIN 14-1609484 | Environment | NY | $4,259,553Mid-sized | 81.21 |
| MoMA PS1EIN 23-7379091 | Arts, Culture, Humanities | NY | $9,938,950Mid-sized | 82.27 |
| Moms in Prayer InternationalEIN 33-0417450 | Religion | CA | $1,374,397Small | 91.35 |
| Monadnock Humane SocietyEIN 02-6005610 | Animals | NH | $1,212,684Small | 84.04 |
| Monadnock United WayEIN 02-0236885 | Community Development | NH | $2,165,227Small | 89.02 |
| Monarch School ProjectEIN 33-0871354 | Education | CA | $2,750,525Small | 97.56 |
| Monell Chemical Senses CenterEIN 23-2020897 | Health | PA | $13,342,596Mid-sized | 86.45 |
| Monmouth County SPCAEIN 21-0679893 | Animals | NJ | $5,004,059Mid-sized | 83.71 |
| Montalvo Arts CenterEIN 94-1249283 | Arts, Culture, Humanities | CA | $5,707,512Mid-sized | 92.12 |
| Montana Environmental Information CenterEIN 23-7337100 | Environment | MT | $527,862Small | 74.50 |
| Montana Food Bank NetworkEIN 81-0421243 | Human Services | MT | $18,322,391Large | 95.47 |
| Montana Wilderness AssociationEIN 51-0198932 | Environment | MT | $2,264,339Small | 96.25 |
| Montclair Art MuseumEIN 22-1487582 | Arts, Culture, Humanities | NJ | $4,778,160Mid-sized | 87.47 |
| Monterey Bay AquariumEIN 94-2487469 | Animals | CA | $89,299,945Large | 97.27 |
| Monterey Museum of ArtEIN 94-1534563 | Arts, Culture, Humanities | CA | $1,881,784Small | 72.36 |
| Monterey SymphonyEIN 94-1584123 | Arts, Culture, Humanities | CA | $1,891,052Small | 79.99 |
| Montgomery Area Food BankEIN 63-0931846 | Human Services | AL | $37,449,188Large | 93.59 |
| Montgomery County Food BankEIN 76-0153892 | Human Services | TX | $20,386,409Large | 89.99 |
| Montgomery County Humane SocietyEIN 52-6044968 | Animals | MD | $1,086,644Small | 82.30 |
| Montgomery County SPCAEIN 23-1425036 | Animals | PA | $2,321,057Small | 92.13 |
| Montgomery County Women's CenterEIN 76-0061208 | Human Services | TX | $5,849,609Mid-sized | 89.33 |
| Montpelier FoundationEIN 31-1620682 | Arts, Culture, Humanities | VA | $11,496,518Mid-sized | 86.75 |
| More Than WordsEIN 04-2784985 | Human Services | MA | $4,031,601Mid-sized | 90.58 |
| Morgan Memorial Goodwill IndustriesEIN 04-2106765 | Human Services | MA | $26,744,337Large | 86.46 |
| Morning Star DevelopmentEIN 54-2086318 | International | CO | $1,322,993Small | 73.40 |
| MorningStar Mission MinistriesEIN 36-2422510 | Human Services | IL | $6,723,363Mid-sized | 89.50 |
| Morris Animal FoundationEIN 84-6032307 | Animals | CO | $10,893,273Mid-sized | 81.92 |
| Morris Habitat for HumanityEIN 22-2675802 | Community Development | NJ | $6,111,048Mid-sized | 92.92 |
| Morton Plant Mease FoundationEIN 59-1751535 | Health | FL | $9,663,293Mid-sized | 88.73 |
| Morven Museum & GardenEIN 22-2817982 | Arts, Culture, Humanities | NJ | $1,360,354Small | 92.04 |
| Mosaic Youth Theatre of DetroitEIN 38-3069610 | Arts, Culture, Humanities | MI | $1,493,069Small | 83.17 |
| MOSIEIN 59-2657399 | Arts, Culture, Humanities | FL | $6,806,453Mid-sized | 82.73 |
| Mote Marine LaboratoryEIN 59-0756643 | Research and Public Policy | FL | $22,091,552Large | 92.18 |