| Merola Opera ProgramEIN 94-6084831 | Education | CA | $3,244,658Small | 86.29 |
| Merrick Community ServicesEIN 41-0693851 | Human Services | MN | $1,534,978Small | 80.72 |
| Merrimack Valley Habitat for HumanityEIN 22-2672831 | Community Development | MA | $3,552,102Mid-sized | 89.22 |
| MERS Missouri Goodwill IndustriesEIN 43-0652657 | Human Services | MO | $161,570,313Large | 88.08 |
| Mesa United WayEIN 86-0198599 | Community Development | AZ | $4,028,932Mid-sized | 95.47 |
| Mesorah Heritage FoundationEIN 11-2981112 | Religion | NY | $8,542,211Mid-sized | 84.50 |
| Mesothelioma Applied Research FoundationEIN 75-2816066 | Health | DC | $2,190,623Small | 89.12 |
| Messenger InternationalEIN 59-3123555 | Religion | CO | $6,491,166Mid-sized | 94.13 |
| Messianic Jewish Bible InstituteEIN 75-2812348 | Religion | TX | $1,757,135Small | 89.80 |
| MetanoiaEIN 20-0310400 | Community Development | SC | $1,704,253Small | 94.07 |
| MetavivorEIN 37-1578088 | Health | MD | $1,943,019Small | 94.69 |
| Methodist Children's HomeEIN 74-1109750 | Human Services | TX | $27,207,490Large | 93.04 |
| Metro Hope Recovery MinistriesEIN 41-0705786 | Health | MN | $1,487,004Small | 78.39 |
| Metro United WayEIN 61-0444680 | Community Development | KY | $25,634,353Large | 88.69 |
| Metro YMCAs of the OrangesEIN 22-1487387 | Human Services | NJ | $33,271,894Large | 92.76 |
| Metrocrest Social ServicesEIN 75-1548334 | Human Services | TX | $5,543,047Mid-sized | 92.38 |
| Metropolitan Family ServicesEIN 36-2167940 | Human Services | IL | $40,309,248Large | 89.20 |
| Metropolitan MinistriesEIN 59-1477007 | Human Services | FL | $26,055,730Large | 90.87 |
| Metropolitan Museum of ArtEIN 13-1624086 | Arts, Culture, Humanities | NY | $492,173,112Large | 95.80 |
| Metropolitan Planning CouncilEIN 36-2382849 | Community Development | IL | $4,318,517Mid-sized | 90.95 |
| MetroSquashEIN 20-2614486 | Human Services | IL | $2,204,245Small | 82.89 |
| Mexican American Legal Defense and Educational FundEIN 74-1563270 | Human and Civil Rights | CA | $6,747,829Mid-sized | 87.37 |
| Mexico Area Family YMCAEIN 43-1147430 | Human Services | MO | $1,236,978Small | 90.94 |
| Meyer Center for Special ChildrenEIN 57-0361503 | Human Services | SC | $3,157,517Small | 76.42 |
| Miami Bridge Youth and Family ServicesEIN 59-2569847 | Human Services | FL | $3,439,642Small | 92.08 |
| Miami City BalletEIN 59-2578534 | Arts, Culture, Humanities | FL | $16,618,823Large | 84.95 |
| Miami FoundationEIN 65-0350357 | Community Development | FL | $61,191,778Large | 94.54 |
| Miami Lighthouse for the Blind and Visually ImpairedEIN 59-0637847 | Human Services | FL | $8,315,513Mid-sized | 98.14 |
| Miami Rescue MissionEIN 59-1743865 | Human Services | FL | $23,405,519Large | 93.19 |
| Michael J. Fox Foundation for Parkinson's ResearchEIN 13-4141945 | Health | NY | $112,000,466Large | 92.92 |
| Michigan 4-H FoundationEIN 38-1539997 | Human Services | MI | $2,237,051Small | 80.60 |
| Michigan Anti-Cruelty SocietyEIN 38-1420301 | Animals | MI | $1,819,319Small | 94.63 |
| Michigan Community ResourcesEIN 20-5764501 | Community Development | MI | $1,072,508Small | 82.06 |
| Michigan Environmental CouncilEIN 38-2517980 | Environment | MI | $2,324,269Small | 91.73 |
| Michigan League for Public PolicyEIN 38-1360557 | Research and Public Policy | MI | $1,796,596Small | 92.85 |
| Michigan Opera TheatreEIN 38-2052726 | Arts, Culture, Humanities | MI | $15,538,195Large | 85.35 |
| Michigan Paralyzed Veterans of AmericaEIN 38-6120911 | Human and Civil Rights | MI | $617,011Small | 76.54 |
| Michigan Roundtable for Diversity and InclusionEIN 20-3122770 | Human and Civil Rights | MI | $1,007,165Small | 75.64 |
| Michigan Sheriffs' AssociationEIN 38-2289072 | Human Services | MI | $1,241,599Small | 75.29 |
| Michigan Theater FoundationEIN 38-2269013 | Arts, Culture, Humanities | MI | $4,853,236Mid-sized | 90.39 |
| Mid America Assistance CoalitionEIN 43-1186173 | Human Services | MO | $1,257,864Small | 82.29 |
| Mid-America Science MuseumEIN 20-2129318 | Arts, Culture, Humanities | AR | $1,975,757Small | 78.05 |
| Mid-Atlantic Foundation for Safety and EducationEIN 23-3100128 | Research and Public Policy | DE | $1,089,582Small | 82.32 |
| Mid-Iowa Council, Boy Scouts of AmericaEIN 42-0981715 | Human Services | IA | $3,162,411Small | 80.64 |
| Mid-Ohio FoodbankEIN 31-0865343 | Human Services | OH | $95,574,910Large | 92.88 |
| Mid-South Food BankEIN 62-1340755 | Human Services | TN | $23,236,010Large | 90.91 |
| Mid-Willamette Family YMCAEIN 93-0479079 | Human Services | OR | $3,059,581Small | 83.43 |
| Middle East Children's AllianceEIN 94-3074600 | International | CA | $2,748,424Small | 91.97 |
| Middle East ForumEIN 23-7749796 | Research and Public Policy | PA | $3,682,718Mid-sized | 88.61 |
| Middle East InstituteEIN 53-0204608 | International | DC | $5,814,897Mid-sized | 97.12 |
| Middle Georgia Community Food BankEIN 58-2484086 | Human Services | GA | $10,581,893Mid-sized | 89.45 |
| Middle Tyger Community CenterEIN 57-1077940 | Human Services | SC | $1,068,622Small | 85.81 |
| Middle Way HouseEIN 23-7300355 | Human Services | IN | $2,098,358Small | 85.73 |
| Middlesex United WayEIN 06-0665170 | Community Development | CT | $1,706,457Small | 87.05 |
| Middleton Outreach MinistryEIN 39-1484945 | Human Services | WI | $3,838,549Mid-sized | 96.66 |
| Midland Community TheatreEIN 75-6003774 | Arts, Culture, Humanities | TX | $1,940,871Small | 85.18 |
| Midland-Odessa Symphony & ChoraleEIN 75-1301544 | Arts, Culture, Humanities | TX | $1,183,096Small | 89.29 |
| Midnight Golf ProgramEIN 38-3580432 | Human Services | MI | $1,521,282Small | 85.54 |
| Midori & FriendsEIN 13-3682472 | Education | NY | $1,764,343Small | 91.24 |
| MidTown ClevelandEIN 34-1381334 | Community Development | OH | $800,640Small | 90.17 |