| Matthew 25: MinistriesEIN 31-1348100 | International | OH | $210,847,427Large | 100.00 |
| Mayor's Fund to Advance New York CityEIN 13-3783906 | Community Development | NY | $22,870,687Large | 87.30 |
| McCallum TheatreEIN 95-2834871 | Arts, Culture, Humanities | CA | $13,663,160Large | 87.50 |
| Medical Benevolence FoundationEIN 62-6046138 | International | TX | $16,488,436Large | 96.46 |
| Medical Teams InternationalEIN 93-0878944 | International | OR | $66,914,611Large | 89.39 |
| MedShareEIN 58-2433968 | International | GA | $27,398,542Large | 93.73 |
| MelwoodEIN 52-0857690 | Human Services | MD | $89,195,314Large | 80.33 |
| Memorial Hermann FoundationEIN 74-1653640 | Health | TX | $18,831,202Large | 82.91 |
| Memphis ZooEIN 23-7236155 | Animals | TN | $15,490,121Large | 85.38 |
| Mercatus CenterEIN 54-1436224 | Research and Public Policy | VA | $27,582,187Large | 88.81 |
| Mercy CorpsEIN 91-1148123 | International | OR | $311,936,065Large | 86.81 |
| Mercy ShipsEIN 26-2414132 | International | TX | $62,442,780Large | 90.67 |
| Mercy-USA for Aid and DevelopmentEIN 38-2846307 | International | MI | $20,393,554Large | 94.69 |
| MERS Missouri Goodwill IndustriesEIN 43-0652657 | Human Services | MO | $161,570,313Large | 88.08 |
| Methodist Children's HomeEIN 74-1109750 | Human Services | TX | $27,207,490Large | 93.04 |
| Metro United WayEIN 61-0444680 | Community Development | KY | $25,634,353Large | 88.69 |
| Metro YMCAs of the OrangesEIN 22-1487387 | Human Services | NJ | $33,271,894Large | 92.76 |
| Metropolitan Family ServicesEIN 36-2167940 | Human Services | IL | $40,309,248Large | 89.20 |
| Metropolitan MinistriesEIN 59-1477007 | Human Services | FL | $26,055,730Large | 90.87 |
| Metropolitan Museum of ArtEIN 13-1624086 | Arts, Culture, Humanities | NY | $492,173,112Large | 95.80 |
| Miami City BalletEIN 59-2578534 | Arts, Culture, Humanities | FL | $16,618,823Large | 84.95 |
| Miami FoundationEIN 65-0350357 | Community Development | FL | $61,191,778Large | 94.54 |
| Miami Rescue MissionEIN 59-1743865 | Human Services | FL | $23,405,519Large | 93.19 |
| Michael J. Fox Foundation for Parkinson's ResearchEIN 13-4141945 | Health | NY | $112,000,466Large | 92.92 |
| Michigan Opera TheatreEIN 38-2052726 | Arts, Culture, Humanities | MI | $15,538,195Large | 85.35 |
| Mid-Ohio FoodbankEIN 31-0865343 | Human Services | OH | $95,574,910Large | 92.88 |
| Mid-South Food BankEIN 62-1340755 | Human Services | TN | $23,236,010Large | 90.91 |
| Midwest Food Bank, NFPEIN 41-2120170 | Human Services | IL | $159,759,526Large | 94.69 |
| Mile High United WayEIN 84-0404235 | Community Development | CO | $27,515,091Large | 89.00 |
| Millennium PromiseEIN 20-3042135 | International | NY | $15,047,799Large | 77.83 |
| Milwaukee Art MuseumEIN 39-0806316 | Arts, Culture, Humanities | WI | $19,236,271Large | 91.01 |
| Milwaukee Jewish FederationEIN 39-0806312 | Community Development | WI | $25,533,075Large | 94.75 |
| Milwaukee Symphony OrchestraEIN 39-6023436 | Arts, Culture, Humanities | WI | $18,202,182Large | 84.79 |
| MIND Research InstituteEIN 33-0798804 | Education | CA | $29,110,497Large | 79.92 |
| Minneapolis Jewish FederationEIN 41-0693866 | Community Development | MN | $15,487,288Large | 86.47 |
| Minnesota Adult & Teen ChallengeEIN 41-1517351 | Health | MN | $33,498,517Large | 99.77 |
| Minnesota Historical SocietyEIN 41-0713907 | Arts, Culture, Humanities | MN | $60,451,270Large | 89.84 |
| Minnesota OrchestraEIN 41-0693875 | Arts, Culture, Humanities | MN | $33,889,255Large | 92.09 |
| Minnesota Public Radio | American Public MediaEIN 41-0953924 | Arts, Culture, Humanities | MN | $98,123,227Large | 92.68 |
| Miracle Hill MinistriesEIN 57-0425826 | Human Services | SC | $17,579,619Large | 89.75 |
| MisericordiaEIN 36-2170153 | Human Services | IL | $68,981,056Large | 94.47 |
| Missouri Botanical GardenEIN 43-0666759 | Environment | MO | $45,210,838Large | 87.76 |
| Missouri History MuseumEIN 43-0654866 | Arts, Culture, Humanities | MO | $21,586,472Large | 97.14 |
| Moffitt Cancer Center FoundationEIN 59-3238636 | Health | FL | $26,895,692Large | 82.04 |
| Montana Food Bank NetworkEIN 81-0421243 | Human Services | MT | $18,322,391Large | 95.47 |
| Monterey Bay AquariumEIN 94-2487469 | Animals | CA | $89,299,945Large | 97.27 |
| Montgomery Area Food BankEIN 63-0931846 | Human Services | AL | $37,449,188Large | 93.59 |
| Montgomery County Food BankEIN 76-0153892 | Human Services | TX | $20,386,409Large | 89.99 |
| Morgan Memorial Goodwill IndustriesEIN 04-2106765 | Human Services | MA | $26,744,337Large | 86.46 |
| Mote Marine LaboratoryEIN 59-0756643 | Research and Public Policy | FL | $22,091,552Large | 92.18 |
| Motion Picture and Television FundEIN 95-1652916 | Human Services | CA | $58,204,376Large | 84.86 |
| Mozilla FoundationEIN 20-0097189 | Education | CA | $24,206,401Large | 96.07 |
| MSPCA-AngellEIN 04-2103597 | Animals | MA | $64,880,058Large | 92.20 |
| Museum of Contemporary Art, ChicagoEIN 36-6154098 | Arts, Culture, Humanities | IL | $21,058,376Large | 87.71 |
| Museum of Fine Arts, BostonEIN 04-2103607 | Arts, Culture, Humanities | MA | $116,703,506Large | 85.68 |
| Museum of FlightEIN 91-0785826 | Arts, Culture, Humanities | WA | $23,340,173Large | 92.15 |
| Museum of ScienceEIN 04-2103916 | Arts, Culture, Humanities | MA | $62,392,418Large | 87.76 |
| Museum of Science and Industry, ChicagoEIN 36-2167797 | Arts, Culture, Humanities | IL | $64,390,473Large | 85.34 |
| Museum of the City of New YorkEIN 13-1624098 | Arts, Culture, Humanities | NY | $21,990,267Large | 93.58 |
| Music CenterEIN 95-2217011 | Arts, Culture, Humanities | CA | $56,537,029Large | 86.09 |