| FIRSTEIN 22-2990908 | Education | NH | $70,357,541Large | 95.87 |
| First BookEIN 52-1779606 | Education | DC | $106,297,627Large | 88.93 |
| First CandleEIN 52-1591162 | Health | CT | $748,744Small | 87.28 |
| First Care Women's ClinicEIN 59-2248369 | Health | FL | $1,405,094Small | 85.94 |
| First DescentsEIN 81-0539964 | Health | CO | $2,999,416Small | 83.53 |
| First GraduateEIN 94-3381171 | Education | CA | $2,025,344Small | 90.80 |
| First Love International MinistriesEIN 36-4423774 | Religion | IL | $3,505,976Mid-sized | 78.53 |
| First Nations Development InstituteEIN 54-1254491 | Human Services | CO | $7,859,206Mid-sized | 98.23 |
| First PlaceEIN 94-3092447 | Education | WA | $2,652,266Small | 72.57 |
| First StarEIN 31-1719436 | Human Services | CA | $1,527,158Small | 90.80 |
| First Things FirstEIN 62-1678048 | Human Services | TN | $1,425,122Small | 83.85 |
| Fisher Center for Alzheimer's Research FoundationEIN 13-3859563 | Health | NY | $4,628,453Mid-sized | 100.00 |
| Fisher House FoundationEIN 11-3158401 | Human Services | MD | $53,308,031Large | 99.83 |
| Fistula FoundationEIN 77-0547201 | International | CA | $8,651,778Mid-sized | 90.43 |
| Fitton Center for Creative ArtsEIN 31-0736673 | Arts, Culture, Humanities | OH | $1,447,601Small | 84.51 |
| Fiver Children's FoundationEIN 13-3993633 | Human Services | NY | $1,900,994Small | 94.62 |
| FixNationEIN 83-0452460 | Animals | CA | $1,275,992Small | 79.61 |
| FJCEIN 13-3848582 | Community Development | NY | $38,216,328Large | 93.69 |
| FLAMEEIN 94-3092706 | International | CA | $489,498Small | 50.07 |
| Flashes of HopeEIN 04-3648694 | Health | OH | $1,759,947Small | 84.03 |
| Flatbush Volunteers of HatzolohEIN 13-3213138 | Health | NY | $1,354,561Small | 73.69 |
| Flathead Food BankEIN 81-0399818 | Human Services | MT | $3,936,109Mid-sized | 86.79 |
| Flatirons Habitat for HumanityEIN 84-1229714 | Community Development | CO | $1,126,039Small | 85.20 |
| Fleet Science CenterEIN 95-6066250 | Arts, Culture, Humanities | CA | $8,900,376Mid-sized | 88.97 |
| Flint Cultural Center CorporationEIN 38-6089075 | Arts, Culture, Humanities | MI | $11,794,762Mid-sized | 89.94 |
| Flint Institute of MusicEIN 38-6159482 | Arts, Culture, Humanities | MI | $6,497,738Mid-sized | 86.65 |
| Florence Crittenton Services of ColoradoEIN 84-0429686 | Human Services | CO | $4,771,942Mid-sized | 95.36 |
| Florence Fuller Child Development CentersEIN 59-1312245 | Human Services | FL | $5,785,127Mid-sized | 92.53 |
| Florence Griswold MuseumEIN 06-6062157 | Arts, Culture, Humanities | CT | $3,149,316Small | 84.83 |
| Florentine Opera CompanyEIN 39-1098132 | Arts, Culture, Humanities | WI | $3,479,195Small | 83.93 |
| Florida Breast Cancer FoundationEIN 01-0694045 | Health | FL | $697,058Small | 92.92 |
| Florida Holocaust MuseumEIN 59-2981494 | Arts, Culture, Humanities | FL | $2,074,789Small | 84.70 |
| Florida Oceanographic SocietyEIN 59-1114306 | Environment | FL | $1,649,436Small | 81.91 |
| Florida Sheriffs Youth RanchesEIN 23-7303117 | Human Services | FL | $15,413,924Large | 86.11 |
| Florida Studio TheatreEIN 23-7362760 | Arts, Culture, Humanities | FL | $7,195,987Mid-sized | 77.97 |
| Florida United Methodist Children's HomeEIN 59-0638479 | Human Services | FL | $14,726,635Large | 90.35 |
| Florida West Coast Public BroadcastingEIN 59-0840626 | Arts, Culture, Humanities | FL | $8,555,365Mid-sized | 93.82 |
| Florida Wildlife FederationEIN 59-1398265 | Animals | FL | $1,419,414Small | 78.11 |
| Florida's Children FirstEIN 52-2372998 | Human Services | FL | $1,300,139Small | 94.54 |
| Flower City Habitat for HumanityEIN 13-3281487 | Community Development | NY | $3,003,163Small | 90.97 |
| Flying Horse FarmsEIN 20-3498125 | Health | OH | $4,019,260Mid-sized | 81.98 |
| Flying House ProductionsEIN 91-1183859 | Arts, Culture, Humanities | WA | $2,325,742Small | 80.01 |
| Flynn Center for the Performing ArtsEIN 03-0277052 | Arts, Culture, Humanities | VT | $6,848,089Mid-sized | 85.05 |
| FOCASEIN 31-1237943 | International | OH | $800,883Small | 74.94 |
| FOCUS (Fellowship of Christians in Universities and Schools, Inc.)EIN 06-0870830 | Religion | CT | $3,563,200Mid-sized | 96.03 |
| Focus Humanitarian Assistance USAEIN 52-1937154 | International | TX | $6,593,953Mid-sized | 90.71 |
| FOCUS North AmericaEIN 26-4427803 | Human Services | PA | $4,829,737Mid-sized | 93.32 |
| Focus On Renewal Sto-Rox Neighborhood CorporationEIN 23-7181440 | Community Development | PA | $2,058,396Small | 81.91 |
| Focus on the FamilyEIN 95-3188150 | Religion | CO | $86,608,051Large | 89.30 |
| Focus Points Family Resource CenterEIN 84-1353944 | Human Services | CO | $2,490,158Small | 92.02 |
| Focus: HOPEEIN 38-1948285 | Human Services | MI | $24,307,131Large | 79.38 |
| Focused Ultrasound FoundationEIN 20-5744808 | Health | VA | $6,428,269Mid-sized | 94.58 |
| Fogarty Institute for InnovationEIN 11-3800306 | Education | CA | $2,762,850Small | 82.23 |
| Folds of HonorEIN 75-3240683 | Education | OK | $19,624,393Large | 97.17 |
| Folksbiene Yiddish TheatreEIN 13-3998872 | Arts, Culture, Humanities | NY | $1,798,228Small | 73.19 |
| Fondos Unidos de Puerto RicoEIN 66-0269222 | Community Development | PR | $9,420,948Mid-sized | 87.06 |
| Fonkoze USAEIN 52-2022113 | International | DC | $1,800,783Small | 77.87 |
| Fontenelle ForestEIN 47-6026109 | Environment | NE | $2,448,954Small | 87.95 |
| Food & FriendsEIN 52-1648941 | Human Services | DC | $8,557,893Mid-sized | 88.01 |
| Food Allergy Research & EducationEIN 13-3905508 | Health | VA | $13,990,992Large | 92.54 |