| Doernbecher Children's Hospital FoundationEIN 93-0579589 | Health | OR | $12,481,925Mid-sized | 83.50 |
| Dogs for Better LivesEIN 93-0681311 | Animals | OR | $3,363,233Small | 95.93 |
| Dogwood AllianceEIN 56-2139120 | Environment | NC | $1,552,587Small | 88.31 |
| Doheny Eye InstituteEIN 95-2916590 | Health | CA | $23,595,251Large | 82.85 |
| Dollar Energy FundEIN 25-1442933 | Human Services | PA | $15,557,633Large | 91.16 |
| Dollywood FoundationEIN 62-1348105 | Education | TN | $2,763,686Small | 84.26 |
| Domestic Abuse Intervention ServicesEIN 39-1268238 | Human Services | WI | $3,256,031Small | 93.70 |
| Domestic Abuse ProjectEIN 41-1356278 | Human Services | MN | $1,595,408Small | 76.76 |
| Domestic Abuse Project of Delaware CountyEIN 23-2053144 | Human Services | PA | $1,766,699Small | 90.06 |
| Domestic Violence Center of Chester CountyEIN 22-2606511 | Human Services | PA | $1,767,014Small | 88.49 |
| Domestic Violence Intervention Services, Inc. (DVIS)EIN 73-1028332 | Human Services | OK | $6,638,122Mid-sized | 93.99 |
| Domestic Violence ProjectEIN 34-1263226 | Human Services | OH | $1,759,397Small | 86.59 |
| Domestic Violence Solutions for Santa Barbara CountyEIN 95-3495141 | Human Services | CA | $1,830,345Small | 84.41 |
| Donald W. Reynolds Boys & Girls ClubEIN 71-0254287 | Human Services | AR | $2,246,524Small | 88.23 |
| DonorsChoose.orgEIN 13-4129457 | Education | NY | $102,666,357Large | 96.66 |
| Doorways for Women and FamiliesEIN 54-1087829 | Human Services | VA | $4,770,512Mid-sized | 93.46 |
| DOROTEIN 13-3264005 | Human Services | NY | $7,626,167Mid-sized | 92.96 |
| Doug Flutie Jr. Foundation For AutismEIN 04-3543134 | Health | MA | $1,281,666Small | 87.31 |
| DoveLewis Emergency Animal HospitalEIN 93-0621534 | Animals | OR | $12,932,704Mid-sized | 86.84 |
| Downline MinistriesEIN 20-1374884 | Religion | TN | $1,631,991Small | 80.75 |
| Downtown Cleveland AllianceEIN 34-1775903 | Community Development | OH | $7,152,083Mid-sized | 81.88 |
| Downtown Community Television CenterEIN 13-2742777 | Arts, Culture, Humanities | NY | $3,066,888Small | 91.45 |
| Downtown Rescue MissionEIN 63-0735295 | Human Services | AL | $8,473,047Mid-sized | 90.69 |
| Downtown Women's CenterEIN 31-1597223 | Human Services | CA | $10,092,147Mid-sized | 89.78 |
| Dr. Susan Love Research FoundationEIN 77-0009065 | Health | CA | $2,750,486Small | 93.08 |
| DREAMEIN 13-4025290 | Human Services | NY | $15,172,457Large | 91.42 |
| Dream FactoryEIN 61-1220742 | Health | KY | $2,252,925Small | 92.38 |
| Dream FoundationEIN 77-0405779 | Health | CA | $4,761,331Mid-sized | 94.27 |
| Dreamchaser PMU Rescue & RehabilitationEIN 20-5168546 | Animals | MO | $1,306,857Small | 68.73 |
| Dreams Come TrueEIN 59-2967803 | Health | FL | $2,459,405Small | 92.22 |
| DreamYard ProjectEIN 13-3759661 | Education | NY | $5,082,563Mid-sized | 86.67 |
| Dress for Success HoustonEIN 76-0579697 | Human Services | TX | $2,618,328Small | 94.63 |
| Dress for Success WorldwideEIN 13-4040377 | Human Services | NY | $22,405,064Large | 91.40 |
| Drisha Institute for Jewish EducationEIN 13-2968932 | Religion | NY | $2,333,063Small | 75.76 |
| Drug Policy AllianceEIN 52-1516692 | Research and Public Policy | NY | $14,612,498Large | 76.86 |
| Drugs for Neglected Diseases Initiative North AmericaEIN 20-8774179 | Health | NY | $4,091,229Mid-sized | 84.44 |
| Dubuque County Historical SocietyEIN 42-6072050 | Arts, Culture, Humanities | IA | $7,001,981Mid-sized | 90.87 |
| Dubuque Regional Humane SocietyEIN 42-6039535 | Animals | IA | $1,228,456Small | 83.90 |
| Dumb Friends LeagueEIN 84-0405254 | Animals | CO | $18,015,992Large | 90.47 |
| DuPage Children's MuseumEIN 36-3565001 | Arts, Culture, Humanities | IL | $3,932,978Mid-sized | 84.78 |
| DuPage PADSEIN 36-3675494 | Human Services | IL | $4,142,129Mid-sized | 90.86 |
| Durham Rescue MissionEIN 58-1482590 | Human Services | NC | $11,976,198Mid-sized | 100.00 |
| Dutchess County SPCAEIN 14-1340058 | Animals | NY | $2,016,618Small | 85.23 |
| Dysautonomia FoundationEIN 13-6145280 | Health | NY | $2,427,386Small | 85.38 |
| Dystonia Medical Research FoundationEIN 95-3378526 | Health | IL | $2,608,986Small | 95.85 |
| Dystrophic Epidermolysis Bullosa Research Association of America (debra of America)EIN 11-2519726 | Health | NY | $1,416,573Small | 93.82 |
| dZi FoundationEIN 84-1595852 | International | CO | $1,351,526Small | 94.74 |