| Delta Waterfowl FoundationEIN 53-0259796 | Animals | ND | $9,628,880Mid-sized | 87.69 |
| Democracy North CarolinaEIN 56-2271150 | Human and Civil Rights | NC | $2,142,045Small | 92.78 |
| Democracy Now!EIN 01-0708733 | Arts, Culture, Humanities | NY | $7,100,320Mid-sized | 81.61 |
| DemosEIN 13-4105066 | Research and Public Policy | NY | $11,762,460Mid-sized | 87.62 |
| Denison Pequotsepos Nature CenterEIN 06-0884024 | Environment | CT | $1,362,888Small | 76.92 |
| Denver Art MuseumEIN 84-6038240 | Arts, Culture, Humanities | CO | $41,996,799Large | 91.19 |
| Denver Botanic GardensEIN 84-0440359 | Environment | CO | $21,365,255Large | 90.84 |
| Denver Center for the Performing ArtsEIN 84-0407760 | Arts, Culture, Humanities | CO | $52,094,113Large | 83.04 |
| Denver Film SocietyEIN 84-0771070 | Arts, Culture, Humanities | CO | $4,826,421Mid-sized | 88.24 |
| Denver Inner City ParishEIN 84-0525768 | Human Services | CO | $2,181,377Small | 88.50 |
| Denver Kids, Inc.EIN 84-1244211 | Education | CO | $2,435,764Small | 82.44 |
| Denver Public Library Friends FoundationEIN 84-6036979 | Arts, Culture, Humanities | CO | $2,403,593Small | 90.64 |
| Denver Rescue MissionEIN 84-6038762 | Human Services | CO | $32,935,233Large | 89.43 |
| Denver Scholarship FoundationEIN 20-5143175 | Education | CO | $9,338,023Mid-sized | 87.89 |
| Denver Street SchoolEIN 84-1216351 | Education | CO | $1,185,964Small | 88.99 |
| Denver Zoological FoundationEIN 84-0502539 | Animals | CO | $42,618,070Large | 88.57 |
| Depression and Bipolar Support Alliance, National OfficeEIN 36-3379124 | Health | IL | $2,387,816Small | 84.40 |
| Dermatology FoundationEIN 04-6115524 | Health | IL | $5,453,832Mid-sized | 81.36 |
| Des Moines Art CenterEIN 42-0680419 | Arts, Culture, Humanities | IA | $8,717,426Mid-sized | 91.88 |
| Des Moines Community PlayhouseEIN 42-0710259 | Arts, Culture, Humanities | IA | $2,660,897Small | 88.27 |
| Descanso Gardens Guild, Inc.EIN 95-2511202 | Environment | CA | $8,740,038Mid-sized | 89.78 |
| Desert AIDS ProjectEIN 33-0068583 | Health | CA | $32,043,691Large | 95.02 |
| Desert Botanical GardenEIN 86-0136925 | Environment | AZ | $15,606,893Large | 83.88 |
| Desire Street MinistriesEIN 72-1218825 | Religion | GA | $2,453,814Small | 94.46 |
| Detroit Historical SocietyEIN 38-1381144 | Arts, Culture, Humanities | MI | $5,818,479Mid-sized | 90.52 |
| Detroit Lakes Community & Cultural CenterEIN 41-1970351 | Human Services | MN | $2,571,753Small | 73.98 |
| Detroit Police Athletic LeagueEIN 38-3314318 | Human Services | MI | $2,897,572Small | 81.98 |
| Detroit Rescue Mission MinistriesEIN 38-1459371 | Human Services | MI | $20,146,632Large | 91.70 |
| Detroit Symphony OrchestraEIN 38-1385132 | Arts, Culture, Humanities | MI | $36,345,989Large | 92.06 |
| Detroit Zoological SocietyEIN 38-6027356 | Animals | MI | $40,691,390Large | 92.44 |
| Development Associates InternationalEIN 23-2838716 | Religion | CO | $5,989,502Mid-sized | 91.91 |
| Developments in LiteracyEIN 33-0843213 | Education | CA | $2,641,317Small | 91.12 |
| Dégagé MinistriesEIN 38-1912094 | Human Services | MI | $1,780,580Small | 80.83 |
| Dia Art FoundationEIN 23-7397946 | Arts, Culture, Humanities | NY | $16,546,314Large | 89.01 |
| Diabetes Action Research and Education FoundationEIN 52-1714027 | Health | MD | $2,249,926Small | 89.44 |
| Diabetes Foundation of MississippiEIN 23-7262987 | Health | MS | $804,695Small | 87.92 |
| Diabetes Research Institute FoundationEIN 59-1361955 | Health | FL | $9,613,760Mid-sized | 83.69 |
| Diabetes Youth FamiliesEIN 94-6003673 | Health | CA | $2,422,432Small | 88.04 |
| Dian Fossey Gorilla Fund InternationalEIN 52-1118866 | Animals | GA | $3,297,143Small | 92.38 |
| DIFFAEIN 13-3224150 | Health | NY | $2,754,888Small | 79.35 |
| Dikembe Mutombo FoundationEIN 58-2359589 | International | GA | $3,333,046Small | 75.95 |
| Dining for WomenEIN 20-0031928 | International | SC | $1,423,715Small | 88.01 |
| Direct ReliefEIN 95-1831116 | International | CA | $1,008,907,873Large | 100.00 |
| Disabled Police and Sheriff's FoundationEIN 36-4494026 | Human Services | MO | $2,265,836Small | 21.56 |
| Disabled Veterans National FoundationEIN 26-1446183 | Human Services | MD | $29,301,117Large | 29.25 |
| DiscipleMakersEIN 25-1411175 | Religion | PA | $4,832,863Mid-sized | 94.16 |
| Discovery Center of SpringfieldEIN 43-1568214 | Arts, Culture, Humanities | MO | $1,154,192Small | 85.38 |
| DISCOVERY Children's MuseumEIN 94-2943891 | Arts, Culture, Humanities | NV | $5,726,927Mid-sized | 88.33 |
| Discovery Eye FoundationEIN 95-4228653 | Health | CA | $897,538Small | 69.62 |
| Discovery Green ConservancyEIN 20-1951465 | Environment | TX | $7,362,363Mid-sized | 94.07 |
| Discovery InstituteEIN 91-1521697 | Research and Public Policy | WA | $5,325,118Mid-sized | 82.97 |
| Discovery MuseumEIN 04-2741645 | Arts, Culture, Humanities | MA | $1,841,437Small | 87.63 |
| Discovery PlaceEIN 56-0529944 | Arts, Culture, Humanities | NC | $15,241,959Large | 91.91 |
| Discovery WorldEIN 39-1691578 | Arts, Culture, Humanities | WI | $9,457,339Mid-sized | 90.71 |
| Diskin Orphan Fund of IsraelEIN 13-5608399 | Human Services | NY | $1,817,844Small | 75.86 |
| District of Columbia College Access ProgramEIN 52-2132835 | Education | DC | $7,157,083Mid-sized | 86.80 |
| DKT InternationalEIN 58-1593137 | International | DC | $199,519,332Large | 88.81 |
| Do SomethingEIN 13-3720473 | Human Services | NY | $10,095,721Mid-sized | 93.37 |
| Doctors CareEIN 84-1150815 | Health | CO | $2,543,801Small | 95.05 |
| Doctors Without Borders, USAEIN 13-3433452 | International | NY | $420,595,919Large | 94.74 |